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| 1 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 2 | Frequency of rheumatic diseases in patients with autoimmune thyroid disease显示文摘 | Mehmet S Sibel G Ender A | 2007 | Rheumatology Inter- national2007，2，7： | 1 |
| 3 | Effect of synthetic and natural culture media on laccase production by white rot fungi显示文摘 | Sibel S Kahraman Ismail H Gurdal | 2002 | Bioresourse Technology2002，82，： | 1 |
| 4 | Pre-disaster invest- ment decisions for strengthening a highway network显示文摘 | SRINIVAS P F SIBEL S DILEK G | 2010 | Com- puters & Operations Research2010，37，： | 1 |
| 5 | Role of host interleukin 1β gene ( IL-1B ) and interleukin 1 receptor antagonist gene ( IL-1RN ) polymorphisms in clinical outcomes in Helicobacter pylori -positive Turkish patients with dyspepsia显示文摘 | Yusuf Erzin Vedat Koksal Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Süha Goksel Ahmet Dirican Bekir Kocazeybek | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 6 | Tongue pressure changes before,during and after crib appliance therapy显示文摘 | Taslan S Sibel B Cenk C | 2010 | Angle Orthod2010，80，3： | 1 |
| 7 | Influence of yogurt and acidophilus yogurt on serum cholesterol levels in mice显示文摘 | SIBEL A SIDDIKGONE A DUZEL S | 1997 | J Daity Sci1997，80，： | 1 |
| 8 | Sensitivity of Verticillium dahliae to prochloraz and prochloraz manganese complex and control of verticillium wilt of cotton in the field 显示文摘 | Sener K Sibel D Suat S | 2005 | Crop Protection2005，22，： | 1 |
| 9 | Chitosan in hibits growth of spoilage micro-organisms in chilled pork products显示文摘 | Satnam S Ron B Sibel R | | 0，，2： | 1 |
| 10 | Synthesis and characteriza tion of acrylamide-acrylic acid hydrogels and adsorption of some textile dyes显示文摘 | SIBEL D DILEK S OLGUN G | 1999 | Nuclear Instruments and Methods in Physics Research1999，151，4： | 1 |
| 11 | Role of host interleukin 1β gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia显示文摘 | Yusuf Erzin Vedat Koksal Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Süha Goksel Ahmet Dirican Bekir Kocazeybek | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 12 | Determination of trace amounts of some metals in samples with high salt content by atomic absorption spectrometry after cobalt-diethyldithiocarbamate coprecipitation 显示文摘 | Ltif E Ugur S Sibel O | 1997 | Talanta1997，44，： | 1 |
| 13 | Determination of trace element contents of baby foods from Turkey显示文摘 | Sibel S Kadriye O S Ozgur D U | 2007 | Food Chemistry2007，105，1： | 1 |
| 14 | β-Galactosidase from Kluyeromyces lactis cell disruption and enzyme immobilization using a cellulosegelatin carrier system显示文摘 | Yasemin N Sibel S | 2004 | Process Biochem2004，39，： | 1 |
| 15 | Chitosan inhibits growth of spoilage micro-organisms in chilled pork products 显示文摘 | Satnam S Ron B Sibel R | 2002 | Food Microbiology2002，19，2： | 1 |
| 16 | Palladium and Mo-lybdenum Mono and Bimetallic Catalysts on Modernitefor Direct NO Decomposition Reaction显示文摘 | Rodrigo S Andréa M Sibele B etc | 2009 | Catalysis Let-ters2009，129，34： | 1 |
| 17 | Sensitivity of Verticillium dahliae to prochloraz and prochloraz-manganese complex and control of Verticillium wilt of cotton in the field显示文摘 | SENER K Sibel D Suat S | 2003 | Crop Protection2003，，22： | 1 |
| 18 | Determination of trace amounts of some metals in samples with high salt content by atomic absorption spectrometry after cobalt-diethyldithiocarbamate coprecipitation显示文摘 | Ltif E Ugur S Sibel O | 1997 | Talanta1997，44，： | 1 |
| 19 | Determination of trace amounts of some metals in samples with high salt content by atomic absorption spectrometry after cobalt-diethldithiocarbamate coprecipitation显示文摘 | LTIF E UGUR S SIBEL O | 1997 | Talanta1997，44，： | 1 |
| 20 | Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy显示文摘 | Jason R McCarthy Irina Y Sazonova S Sibel Erdem Tetsuya Hara Brian D Thompson Purvish Patel Ion Botnaru Charles P Lin Guy L Reed Ralph Weissleder Farouc A Jaffer | 2012 | Nanomedicine2012，，7： | 1 |
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