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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Preparation,characterization and photocatalytic performance of Mo-doped ZnO photocatalysts显示文摘A series of Mo-doped ZnO photocatalysts with different Mo-dopant concentrations have been prepared by a grinding-calcination method.The structure of these photocatalysts was characterized by a variety of methods,including N 2 physical adsorption,X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared(FT-IR) spectroscopy,photoluminescence(PL) emission spectroscopy,and UV-vis diffuse reflectance spectroscopy(DRS).It was found that Mo 6+ could enter into the crystal lattice of ZnO due to the radius of Mo 6+(0.065 nm) being smaller than that of Zn 2+(0.083 nm).XRD results indicated that Mo 6+ suppressed the growth of ZnO crystals.The FT-IR spectroscopy results showed that the ZnO with 2 wt.% Mo-doping has a higher level of surface hydroxyl groups than pure ZnO.PL spectroscopy indicated that ZnO with 2 wt.% Mo-doping also exhibited the largest reduction in the intensity of the emission peak at 390 nm caused by the recombination of photogenerated hole-electron pairs.The activities of the Mo-doped ZnO photocatalysts were investigated in the photocatalytic degradation of acid orange II under UV light(λ = 365 nm) irradiation.It was found that ZnO with 2 wt.% Mo-doping showed much higher photocatalytic activity and stability than pure ZnO.The high photocatalytic performance of the Mo-doped ZnO can be attributed to a great improvement in the surface properties of ZnO,higher crystallinity and lower recombination rate of photogenerated hole-electron(e-/h+) pairs.Moreover,the undoped Mo species may exist in the form of MoO3 and form MoO3 /ZnO heterojunctions which further favors the separation of e-/h+ pairs. | YU ChangLin YANG Kai SHU Qing YU Jimmy C CAO FangFang LI Xin ZHOU XiaoChun | 2012 | Science China Chemistry2012，55，9： | 8 |
| 3 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 4 | Efficient implementation of weighted ENO schemes显示文摘 | Jiang G Shu C W | 1996 | J Comput phys1996，，： | 2 |
| 5 | Muhi-FBG interrogation based on a spectrum-limited Fourier domain mode locking fiber laser 显示文摘 | Chen D Shu C He S | 2008 | Opt Lett2008，33，13： | 1 |
| 6 | Hyperbranched poly (ether ketone) with carboxylic acid terminal groups synthesis, characterization, derivatization显示文摘 | Shu C F Leu C M | 1999 | Macromolecules1999，32，1： | 1 |
| 7 | Influence of the Reynolds number on chaotic mixing in a spatially periodic micromixer and its characterization using dynamical system techniques 显示文摘 | XIA H M SHU C WAN Y M | 2006 | Journal of Micromechanics and Microengineering2006，16，1： | 1 |
| 8 | Anatomic study and review of the literature on the Martin-Gruber anastomosis显示文摘 | Shu H Chantelot C Oberlin C | 1999 | Morphologie1999，83，260： | 1 |
| 9 | Free vibration analysis of curvilinear quadrilateral plates by the differential quadrature method显示文摘 | Shu C Chen W Du H | 2000 | J Comput Phys2000，163，2： | 1 |
| 10 | Efficient Implementation of Essentially Non- oscillatory Shock Capturing Schemes 显示文摘 | Shu C W Osher S | 1988 | Journal of Computational Physics1988，77，： | 1 |
| 11 | Optimization of polysaeeharides(ABP)extraction from the fruiting bodies of Agarieusblazei Mmillusing response surfae methodology显示文摘 | Liu J C Shu M Wen X C | 2009 | Carbohydrate Polymers2009，78，2： | 1 |
| 12 | Nanofihration membrane bioreactor for continuous asymmetric reduction of 2-ketoulutarate to produce L-glutamate with NADH regeneration显示文摘 | Lin Shu - Su Harada T Hata C | 1997 | J Ferm Bioeng1997，83，1： | 1 |
| 13 | Application of generalized differential quadrature to solve two-dimensional incompressible Navier-Stokes equations显示文摘 | Shu C Richards B E | 1992 | Int J Numer Methods Fluids1992，15，： | 1 |
| 14 | Application of generalized differntial quadrature to solve two-dimensional incom-pressible navier-stokes equations显示文摘 | SHU C RICHARD B | 1992 | Int Numer Meth Fluids1992，15，： | 1 |
| 15 | Some volatile compounds formed from thermal interaction of glucose with glycine,diglycine,triglycine,and tetraglycine显示文摘 | Oh Y C Shu C K Ho C T | 1991 | J Agric Food Chem1991，39，： | 1 |
| 16 | 显示文摘 | Chuang F S Tsen W C Shu Y C | 2004 | Polymer Degration and Stability2004，84，： | 1 |
| 17 | Efficient implementation of weighted ENO schemes显示文摘 | JIANG G S SHU C W | 1996 | J Comp Phys1996，126，： | 1 |
| 18 | Efficient implementation of weighted ENO schemes显示文摘 | Jiang G Shu C W | 1996 | Journal of Computational Physics1996，126，1： | 1 |
| 19 | A macroscopic approach to the lane for- mation phenomenon in pedestrian counterflow 显示文摘 | Xiong T Zhang P Wong S C Shu C W Zhang M | 2011 | Chinese Physical Letters2011，28，10： | 1 |
| 20 | Emergency endovascular stent-grafting for acute type B aortic dissection with symptomatic malperfusion显示文摘 | Shu C Fang K Luo M | 2013 | Int Angiol2013，32，5： | 1 |
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