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| 1 | Sleep disorders and chronic kidney disease显示文摘Sleep disorders have a profound and well-documented impact on overall health and quality of life in the general population. In patients with chronic disease, sleep disorders are more prevalent, with an additional morbidity and mortality burden. The complex and dynamic relationship between sleep disorders and chronic kidney disease(CKD) remain relatively little investigated. This article presents an overview of sleep disorders in patients with CKD, with emphasis on relevant pathophysiologic underpinnings and clinical presentations. Evidence-based interventions will be discussed, in the context of individual sleep disorders, namely sleep apnea, insomnia, restless leg syndrome and excessive daytime sleepiness. Limitations of the current knowledge as well as future research directions will be highlighted, with a final discussion of different conceptual frameworks of the relationship between sleep disorders and CKD. | Stephanie C Maung Ammar El Sara Cherylle Chapman Danielle Cohen Daniel Cukor | 2016 | World Journal of Nephrology2016，5，3： | 13 |
| 2 | Atopic eczema treatment now and in the future:Targeting the skin barrier and key immune mechanisms in human skin显示文摘The skin facilitates a number of key roles but its functioning can be impaired by disease. Atopic eczema is a chronic inflammatory disease where the skin barrier has become leaky, and inflammation occurs. It affects up to 20% of children and 3% of adults worldwide, manifesting as red itchy patches of skin with varying severity. This review aims to investigate the leaky skin barrier and immune mechanisms from the perspective of potential novel treatments. The complexity of atopic eczema as a disease is what makes it difficult to treat. Genome-wide association studies have highlighted possible genetic variations associated with atopic eczema, however in some cases, individuals develop the disease without these genetic risk factors. Loss of function mutations in the filaggrin gene are one of these associations and this is plausible due to its key role in barrier function. The Th2 immune response is the link with regards to the immune mechanisms as atopic inflammation often occurs through increased levels of interleukin(IL)-4 and IL-13. Eczematous inflammation also creates susceptibility to colonisation and damage by bacteria such as Staphylococcus aureus. Potential novel treatments are becoming ever more specific, offering the hope of fewer side effects and better disease control. The best new treatments highlighted in this review target the immune response with human beta defensin 2, phosphodiesterase-4 inhibitors and monoclonal antibodies all showing promise. | David C Bell Sara J Brown | 2017 | World Journal of Dermatology2017，6，3： | 5 |
| 3 | Upper gastrointestinal bleeding risk scores: Who, when andwhy?显示文摘Upper gastrointestinal bleeding(UGIB) remains a significant cause of hospital admission. In order to stratify patients according to the risk of the compli-cations, such as rebleeding or death, and to predict the need of clinical intervention, several risk scores have been proposed and their use consistently recommended by international guidelines. The use of risk scoring systems in early assessment of patients suffering from UGIB may be useful to distinguish high-risks patients, who may need clinical intervention and hospitalization, from low risk patients with a lower chance of developing complications, in which management as outpatients can be considered. Although several scores have been published and validated for predicting different outcomes, the most frequently cited ones are the Rockall score and the Glasgow Blatchford score(GBS). While Rockall score, which incorporates clinical and endoscopic variables, has been validated to predict mortality, the GBS, which is based on clinical and laboratorial parameters, has been studied to predict the need of clinical intervention. Despite the advantages previously reported, their use in clinical decisions is still limited. This review describes the different risk scores used in the UGIB setting, highlights the most important research, explains why and when their use may be helpful, reflects on the problems that remain unresolved and guides future research with practical impact. | Sara Monteiro Tiago Cúrdia Gonçalves Joana Magalhães JoséCotter | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 5 |
| 4 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 5 | 冠状动脉内皮功能障碍患者胆固醇流出异常,高密度脂蛋白颗粒物浓度降低显示文摘冠状动脉内皮功能障碍(endothelial dysfunction,ED)是动脉粥样硬化早期标志,增加心血管事件发生风险。该研究假设胆固醇流出容量和高密度脂蛋白颗粒浓度(high-density lipoprotein particle concentration,HDL-PIMA)较高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)更能预测ED。 | 刘莉 叶鹏 Monette JS Hutchins PM Ronsein GE Wimberger J Irwin AD Tang C Sara JD Shao B Vaisar T Lerman A Heinecke JW | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 6 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 7 | Unusual segregation products in sperm from a pericentric inversion 17 heterozygote 显示文摘 | Monica M Mikhaail- Philips /EBarbara C McGillivray Sara J | 2005 | Hum Genet2005，117，： | 1 |
| 8 | Educational Applications of IR and RamanSpectroscopy:A Comparison of Experiment and Theory显示文摘 | Brian L M Sara M C | 2000 | Chemi-cal Education2000，77，5： | 1 |
| 9 | Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells显示文摘 | Alessandra C Sara P Fabrizio D A | 2009 | J Pineal Res2009，46，3： | 1 |
| 10 | Nitrogen compounds characterization in atmospheric gas oil and light cycleoil from a blend of Mexican crudes显示文摘 | Georgina C Laredo Sara Leyva Regina Alvarez | | 0，，： | 1 |
| 11 | Reversible middle cerebral artery occlusion without carniectomy in rats显示文摘 | Enrique I Phillip RW Sara C | 1989 | Stroke1989，20，： | 1 |
| 12 | Modified point diffraction interferometer for inspection and evaluation of ophthalmic components显示文摘 | EVA A SARA C RALF B | 2006 | OSA2006，26，3： | 1 |
| 13 | Reversible middle cerebral atery occlusion without carniectomy in rats 显示文摘 | Enrique I Phillip RW Sara C | 1989 | Stroke1989，20，8： | 1 |
| 14 | Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients 显示文摘 | BABILONI C SARA M VECCHIO F | 2009 | Clin Neurophysiol2009，120，4： | 1 |
| 15 | Pyrrolidine dithiocarbamate protects mice from Lethal shock induced by LPS or TNF-α显示文摘 | PILAR L SARA M M PABBO C D et al | 1999 | Eur J Immunol1999，29，6： | 1 |
| 16 | Cortical sources of resting- state alpha rhythm are abnormal in pm sistent vegelative siale pa- tients 显示文摘 | Balfihmi C Sara M Veeehio F el al | 2009 | Clin Neurophysio12009，120，2： | 1 |
| 17 | Thoracic radiotherapy for limited-stage small cell lung cancer: issues of timing, volumes, dose, and fractionation显示文摘 | Sara C Erridge Nerin Murray | 2003 | Semin Oncol2003，30，1： | 1 |
| 18 | Evaluation of a me- thod for assaying sulfonamide antimicrobial residues in cheese: hot-water extraction and liquid chromatogra- phy-tandem mass spectrometry显示文摘 | Giorgio B Sara B Roberta C | 2006 | Journal of Agricultural andFoocl Chemistry2006，54，13： | 1 |
| 19 | The ret C620R mutation affects renal and enteric development in a mouse model of hirschsprung's disease 显示文摘 | Cristiana C Sara B Elena R | 2006 | Am J Pathol2006，168，： | 1 |
| 20 | A headspace solid-phase microextraction gas-chromatographic mass-spectrometric method to quantify hexanal in butter during storage as marker of lipid oxidation显示文摘 | SARA P SILVIA S LUCA M C | 2011 | Food Chemistry2011，127，2： | 1 |
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