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| 1 | Limbal stem cells: Central concepts of corneal epithelial homeostasis显示文摘A strong cohort of evidence exists that supports the localisation of corneal stem cells at the limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling properties, high proliferative potential when required, clonogenicity, absence of differentiation marker expression coupled with positive expression of progenitor markers, multipotency, centripetal migration, requirement for a distinct niche environment and the ability of transplanted limbal cells to regenerate the entire corneal epithelium. The existence of limbal stem cells supports the prevailing theory of corneal homeostasis, known as the XYZ hypothesis where X represents proliferation and stratification of limbal basal cells, Y centripetal migration of basal cells and Z desquamation of superficial cells. To maintain the mass of cornea, the sum of X and Y must equal Z and very elegant cell tracking experiments provide strong evidence in support of this theory. However, several recent stud-ies have suggested the existence of oligopotent stem cells capable of corneal maintenance outside of the limbus. This review presents a summary of data which led to the current concepts of corneal epithelial homeostasis and discusses areas of controversy surrounding the existence of a secondary stem cell reservoir on the corneal | Jinny J Yoon Salim Ismail Trevor Sherwin | 2014 | World Journal of Stem Cells2014，6，4： | 11 |
| 2 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 3 | Asymptomatic bacteriuria among hospitalized diabetic patients:Should they be treated?显示文摘Diabetes Mellitus is a significant health care challenge in the United States.The Center for Disease Control and Prevention estimates approximately 9.4%of patients in the United States are afflicted by diabetes.The Infectious Disease Society of America asymptomatic bacteriuria in women as two consecutive cleancatch voided urine specimens with isolation of the same bacterial strain in counts≥105 cfu/mL It is understood that diabetic patients tend to be at higher risk for infections than non-diabetics.Urinary tract infections(UTIs)tend to be the most common infection contracted by this population.UTIs are not only a significant cause of morbidity and mortality,they are also a significant financial burden.The data are conflicting,in regard to treating asymptomatic bacteriuria in diabetic patients to avoid hospital complications and ultimately decrease healthcare costs associated with these complications.However,clinicians continue to prescribe antibiotics empirically.Further randomized controlled study looking into the specific population as immunocompromised diabetic patients,patient with diabetic ketoacidosis and patient in intensive care unit needs to be undertaken. | Manuel J Ramos-Ramirez Salim Surani | 2019 | World Journal of Meta-Analysis2019，7，7： | 2 |
| 4 | Persistenthyperglycemia in severe traumatic brain injury:anindependent predictor of outcome显示文摘 | Salim A Hadjizacharia P Dubose J | 2009 | Am Surg2009，75，1： | 1 |
| 5 | Total right ventricular dependent coronary circulation in pulmonary atresia with intact ventricular septum显示文摘 | Love J Salim MA | 2004 | Ann Thorac Surg2004，77，3： | 1 |
| 6 | Positive serum ethanol level and mortality in moderate to severe traumatic brain injury 显示文摘 | Salim A Ley E J Cryer HG | 2009 | Arch Surg2009，144，9： | 1 |
| 7 | Liver tumorge- nicity o f trimethylarsine oxide in male Fischer 344 rats - associat ion with oxidative DNA damage and enhanced cell proliferation 显示文摘 | Shen J Wanibuchi H Salim E I | 2003 | Carcinogenesis2003，24，11： | 1 |
| 8 | Analysis and design of pultruded FRP shapes under bending显示文摘 | DAVALOS J F SALIM H A QIAO P | 1996 | Composite Part B: Engineering1996，27，34： | 1 |
| 9 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 10 | Virtual Communities of Practice Success Model to Support Knowledge Sharing Behaviour in Health- care Sector显示文摘 | Alali H Salim J | 2013 | Procedia Technology2013，，11： | 1 |
| 11 | Sphere-forming corneal cells repopulate dystrophic keratoconic stroma:Implications for potential therapy显示文摘BACKGROUND Keratoconus is a degenerative corneal disease characterised by aberrant cell behaviour and loss of matrix that can result in vision loss.Cells extracted from peripheral corneas can form stem cell-enriched spheres,which have shown the potential to repopulate the normal peripheral corneal stroma in vitro upon sphere implantation but have not been previously studied in keratoconic tissue.AIM To investigate the therapeutic potential of stem cell-enriched spheres formed from extracted peripheral human corneal cells when introduced to keratoconic tissue.METHODS Stem cell-enriched spheres were formed from extracts of normal cadaveric human peripheral corneal cells.These spheres were implanted into incisions created in full thickness and onto the surface of 10μm thin sections of keratoconic and normal stromal tissues in vitro.Tissue sections were used to maximise use of limited keratoconic tissue available for research.Living cells were stained with Calcein-AM and visualised with stereo and fluorescence microscopy to assess survival and behaviours between the time of implantation day 0 and 14 d(D14)from implantation.Sphere cells in implanted tissues were characterised for stem cell and differentiation markers using immunohistochemistry and droplet digital PCR to assess the potential implications of these characteristics in the use of spheres in keratoconus treatment.RESULTS Spheres were successfully implanted into full-thickness central corneal tissue and onto the surface of 10μm thin en face tissue sections.No observable differences were seen in sphere migration,proliferation or differentiation in keratoconic tissue compared to normal between day 0 and D14.Spheres stained positively with Calcein-AM up to D14.Cell migration increased from day 0 to D14,occurring radially in three dimensions from the sphere and in alignment with tissue edges.Cell proliferation marker,EdU,was detected at day 10.Implanted spheres stained positively for putative stem cell markersΔNp63αand ABCB5,while ABCG2,ABCB5,ΔNp63 and p63αwere detectable by droplet digital PCR up to D14.Double immunolabelling revealed absence of ABCB5 staining in migrated cells but positive staining of alpha smooth muscle actin(myofibroblast marker)in some migrated cells.Droplet digital PCR showed similar expression patterns of differentiation markers but a reduction in stem cell markers between normal and keratoconic tissue with an increase in stromal cell markers and a reduction in epithelial cell markers,indicating an appropriate response to repopulating diseased tissue.CONCLUSION Cells from implanted stem cell-enriched spheres can repopulate a keratoconic corneal stromal surface in a directed manner and exhibit migratory stromal cell phenotypes. | Himanshu Wadhwa Salim Ismail Jennifer J McGhee Bert Van der Werf Trevor Sherwin | 2020 | World Journal of Stem Cells2020，12，1： | 1 |
| 12 | Persistent hyperglycemia in severe traumatic brain injury:an independent predictor of outcome显示文摘 | Salim A Hadjizacharia P Dbbose J | 2009 | Am Surg2009，75，1： | 1 |
| 13 | Sorption Isotherm-Sequential Extraction Analysis of Heavy Metal Retention in Landfill Liners显示文摘 | SALIM I A MILLER C J HOWARD J L | 1996 | Soil Science Society of America Journal1996，60，1： | 1 |
| 14 | Comparative study of the ad- sorption on chitosan beads of phthalate esters and their degrada- tion products 显示文摘 | SALIM C J LIU H KENNEDY J F | 2010 | Carbohydrate Polymers2010，81，3： | 1 |
| 15 | Analysis of Sudan Vegetation Dynamics Using NOAA AVHRR NDVI Data from 1982- 1993显示文摘 | Salim H A Chen X Gong J | 2008 | Asian Journal of Earth Sciences2008，1，1： | 1 |
| 16 | Intraabdominal injury is common in blunt trauma patients who sustain spinal cord injury显示文摘 | Salim A Ottochian M Gertz R J | 2007 | Am Surg2007，73，10： | 1 |
| 17 | Importance of disrupted intestinal barrier in inflammatory bowel diseases显示文摘 | SALIM S Y SDERHOLM J D | 2011 | Inflamm Bowel Dis2011，17，： | 1 |
| 18 | Persistent hyperglycemia in severe trau- matic brain injury: an independent pre- dictor of outcome 显示文摘 | Salim A Hadjizacharia P Dubose J | 2009 | Am Surg2009，75，： | 1 |
| 19 | Persistent hyperglycemia in severe traumatic brain injury : an independent predictor of outcome 显示文摘 | Salim A Hadjizacharia P Dubose J | 2009 | Am Surg2009，75，1： | 1 |
| 20 | Comparative study of the adsorption on chitosan beads of phthalate esters and their degradation products显示文摘 | Salim C J Liu H Kennedy J F | 2010 | Carbohydrate Polymers2010，81，3： | 1 |
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