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| 1 | Limbal stem cells: Central concepts of corneal epithelial homeostasis显示文摘A strong cohort of evidence exists that supports the localisation of corneal stem cells at the limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling properties, high proliferative potential when required, clonogenicity, absence of differentiation marker expression coupled with positive expression of progenitor markers, multipotency, centripetal migration, requirement for a distinct niche environment and the ability of transplanted limbal cells to regenerate the entire corneal epithelium. The existence of limbal stem cells supports the prevailing theory of corneal homeostasis, known as the XYZ hypothesis where X represents proliferation and stratification of limbal basal cells, Y centripetal migration of basal cells and Z desquamation of superficial cells. To maintain the mass of cornea, the sum of X and Y must equal Z and very elegant cell tracking experiments provide strong evidence in support of this theory. However, several recent stud-ies have suggested the existence of oligopotent stem cells capable of corneal maintenance outside of the limbus. This review presents a summary of data which led to the current concepts of corneal epithelial homeostasis and discusses areas of controversy surrounding the existence of a secondary stem cell reservoir on the corneal | Jinny J Yoon Salim Ismail Trevor Sherwin | 2014 | World Journal of Stem Cells2014，6，4： | 11 |
| 2 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 3 | Pancreatic pseudocyst or a cystic tumor of the pancreas?显示文摘Pancreatic pseudocysts are the most common cystic lesions of the pancreas and may complicate acute pancreatitis, chronic pancreatitis, or pancreatic trauma. While the majority of acute pseudocysts resolve spontaneously, few may require drainage. On the other hand, pancreatic cystic tumors, which usually require extirpation, may disguise as pseudocysts. Hence, the distinction between the two entities is crucial for a successful outcome. We conducted this study to highlight the fundamental differences between pancreatic pseudocysts and cystic tumors so that relevant management plans can be devised. We reviewed the data of patients with pancreatic cystic lesions that underwent intervention between June 2007 and December 2010 in our hospital. We identified 9 patients(5 males and 4 females) with a median age of 40 years(range, 30–70 years). Five patients had pseudocysts, 2 had cystic tumors, and 2 had diseases of undetermined pathology. Pancreatic pseudocysts were treated by pseudocystogastrostomy in 2 cases and percutaneous drainage in 3 cases. One case recurred after percutaneous drainage and required pseudocystogastrostomy. The true pancreatic cysts were serous cystadenoma, which was treated by distal pancreatectomy, and mucinous cystadenocarcinoma, which was initially treated by drainage, like a pseudocyst, and then by distal pancreatectomy when its true nature was revealed. We conclude that every effort should be exerted to distinguish between pancreatic pseudocysts and cystic tumors of the pancreas to avoid the serious misjudgement of draining rather than extirpating a pancreatic cystic tumor. Additionally, percutaneous drainage of a pancreatic pseudocyst is a useful adjunct that may substitute for surgical drainage. | Mohammad Ezzedien Rabie Ismail El Hakeem Mohammad Saad Al Skaini Ahmad El Hadad Salim Jamil Mian Tahir Shah Mahmoud Obaid | 2014 | Chinese Journal of Cancer2014，33，2： | 2 |
| 4 | Fabrication, fouling and foulant analyses of asymmetric polysulfone (PSF) ultra{iltration membrane fouled with natural or- ganic matter (NOM) source waters显示文摘 | Zularisam A W Ismail A F Salim M R | 2007 | Journal nf Mem- brane Science2007，299，97： | 1 |
| 5 | A review of the effects of emerging contaminants in wastewater and options for their removal显示文摘 | Bolong N Ismail A Salim M R | 2009 | Desalination2009，239，1： | 1 |
| 6 | The effects of natural organic matter ( NOM ) fractions on fouling characteristics and flux recovery of ultrafihration membranes 显示文摘 | ZULARISAM A W ISMAIL A F SALIM M R | 2007 | Desalination2007，212，： | 1 |
| 7 | Sphere-forming corneal cells repopulate dystrophic keratoconic stroma:Implications for potential therapy显示文摘BACKGROUND Keratoconus is a degenerative corneal disease characterised by aberrant cell behaviour and loss of matrix that can result in vision loss.Cells extracted from peripheral corneas can form stem cell-enriched spheres,which have shown the potential to repopulate the normal peripheral corneal stroma in vitro upon sphere implantation but have not been previously studied in keratoconic tissue.AIM To investigate the therapeutic potential of stem cell-enriched spheres formed from extracted peripheral human corneal cells when introduced to keratoconic tissue.METHODS Stem cell-enriched spheres were formed from extracts of normal cadaveric human peripheral corneal cells.These spheres were implanted into incisions created in full thickness and onto the surface of 10μm thin sections of keratoconic and normal stromal tissues in vitro.Tissue sections were used to maximise use of limited keratoconic tissue available for research.Living cells were stained with Calcein-AM and visualised with stereo and fluorescence microscopy to assess survival and behaviours between the time of implantation day 0 and 14 d(D14)from implantation.Sphere cells in implanted tissues were characterised for stem cell and differentiation markers using immunohistochemistry and droplet digital PCR to assess the potential implications of these characteristics in the use of spheres in keratoconus treatment.RESULTS Spheres were successfully implanted into full-thickness central corneal tissue and onto the surface of 10μm thin en face tissue sections.No observable differences were seen in sphere migration,proliferation or differentiation in keratoconic tissue compared to normal between day 0 and D14.Spheres stained positively with Calcein-AM up to D14.Cell migration increased from day 0 to D14,occurring radially in three dimensions from the sphere and in alignment with tissue edges.Cell proliferation marker,EdU,was detected at day 10.Implanted spheres stained positively for putative stem cell markersΔNp63αand ABCB5,while ABCG2,ABCB5,ΔNp63 and p63αwere detectable by droplet digital PCR up to D14.Double immunolabelling revealed absence of ABCB5 staining in migrated cells but positive staining of alpha smooth muscle actin(myofibroblast marker)in some migrated cells.Droplet digital PCR showed similar expression patterns of differentiation markers but a reduction in stem cell markers between normal and keratoconic tissue with an increase in stromal cell markers and a reduction in epithelial cell markers,indicating an appropriate response to repopulating diseased tissue.CONCLUSION Cells from implanted stem cell-enriched spheres can repopulate a keratoconic corneal stromal surface in a directed manner and exhibit migratory stromal cell phenotypes. | Himanshu Wadhwa Salim Ismail Jennifer J McGhee Bert Van der Werf Trevor Sherwin | 2020 | World Journal of Stem Cells2020，12，1： | 1 |
| 8 | Behaviors of natural organic matter in membrane filtration for surface water treatment:a review显示文摘 | Zularisam A W Ismail A F Salim R | 2006 | Desalination2006，194，1： | 1 |
| 9 | Behaviours of natural organic matter in membrane filtration for surface water treatment-a review 显示文摘 | Zularisam AW Ismail AF Salim R | 2006 | Desalination2006，194，： | 1 |
| 10 | Development and characterization of novel charged surface modification macromole cule to polyethersulfone hollow fiber membrane with polyvinylpyrrolidone and water显示文摘 | Bolong N Ismail A F Salim M R | | 0，，1： | 1 |
| 11 | The effects of natural organic matter (NOM) fractions on fouling characteristics and flux recovery of ultrafiltration membranes显示文摘 | A W Zularisam A F Ismail M R Salim | 2007 | Desalination2007，212，13： | 1 |
| 12 | Fabrica- tion, fouling and foulant analyses of asymmetric polysulfone (PSF) ultrafiltration membrane fouled with natural organic matter (NOM) source waters 显示文摘 | A W Zularisam A F Ismail M R Salim | 2007 | Journal of Membrane Science2007，299，12： | 1 |
| 13 | Behaviours of natural organic matter in membrane filtration for surface water treatment — a review显示文摘 | A.W. Zularisam A.F. Ismail Razman Salim | 2006 | Desalination2006，，1： | 1 |
| 14 | Development and characterization of novel charged surface modification macromolecule to polyethersulfone hollow fiber membrane with polyvinylpyrrolidone and water显示文摘 | Bolong N Ismail A F Salim M R | 2009 | Journal of Membrane Science2009，331，12： | 1 |
| 15 | Application of coagulation-ultmfiltration hybrid process for drinking water treatment: optimization of operating conditions using experimental design 显示文摘 | Zularisam A W Ismail A F Salim M R | 2009 | Separation and Purification Technology2009，65，2： | 1 |
| 16 | Behaviours of natural organic matter in membrane filtration for显示文摘 | Zularisam A W Ismail A F Salim R | 2006 | Desalination2006，194，： | 1 |
| 17 | Development and characterization of novel charged surface modification macromolecule to polyethersulfone hollow fiber membrane with polyvinylpyrrolidone and water显示文摘 | BOLONG N ISMAIL A F SALIM M R | 2009 | Journal of Membrane Science2009，331，1： | 1 |
| 18 | The effects of natural organic matter (NOM) fractions on fouling characteristics and flux recovery of ultrafiltration membranes 显示文摘 | Zularisam A W Ismail A F Salim M R | 2007 | Desalination2007，212，1： | 1 |
| 19 | The effects of natural organic matter (NOM) fractions on fouling characteristics and flux recovery of ultrafiltration membranes 显示文摘 | Zularisam A W Ismail A F Salim M R | 2007 | Desalination2007，212，： | 1 |
| 20 | Behaviours of natural organic matter in membrane filtration for surface water treatment-a review 显示文摘 | Zularisam A W Ismail A F Salim R | 2006 | Desalination2006，194，13： | 1 |
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