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| 1 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 2 | Shunts, channels and lipoprotein endosomal traffic: a new model of cholesterol homeostasis in the hepatocyte显示文摘The liver directs cholesterol metabolism in the organism.All the major fluxes of cholesterol within the body involve the liver:dietary cholesterol is directed to the liver;cholesterol from peripheral cells goes to the liver;the liver is a major site of cholesterol synthesis for the organism;cholesterol is secreted from the liver within the bile,within apoB lipoproteins and translocated to nascent HDL.The conventional model of cholesterol homeostasis posits that cholesterol from any source enters a common,rapidly exchangeable pool within the cell,which is in equilibrium with a regulatory pool.Increased influx of cholesterol leads rapidly to decreased synthesis of cholesterol.This model was developed based on in vitro studies in the fibroblast and validated only for LDL particles.The challenges the liver must meet in vivo to achieve cholesterol homeostasis are far more complex.Our model posits that the cholesterol derived from three different lipoproteins endosomes has three different fates:LDL-derived cholesterol is largely recycled within VLDL with most of the cholesterol shunted through the hepatocyte without entering the exchangeable pool of cholesterol;high density lipoprotein-derived CE is transcytosed into bile;and chylomicron remnant-derived cholesterol primarily enters the regulatory pool within the hepatocyte.These endosomal channels represent distinct physiological pathways and hepatic homeostasis represents the net result of the outcomes of these distinct channels.Our model takes into account the distinct physiological challenges the hepatocyte must meet,underlie the pathophysiology of many of the apoB dyslipoproteinemias and account for the sustained effectiveness of therapeutic agents such as statins. | Robert Scott Kiss Allan Sniderman | 2017 | The Journal of Biomedical Research2017，31，2： | 2 |
| 3 | Apolipoprotein A1 and B显示文摘 | Allan D. Sniderman Santica M. Marcovina | 2006 | Clinics in Laboratory Medicine2006，，4： | 1 |
| 4 | Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study显示文摘 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mohammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf | 2008 | The Lancet2008，，9634： | 1 |
| 5 | Acylation stimulating protein (ASP) Deficiency Alters postprandial and Adipose Tissue Metabolism in male mice显示文摘 | Allan D Sniderman | 1999 | Biol Chem1999，274，36： | 1 |
| 6 | The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk显示文摘 | G?ran Walldius Ingmar Jungner Are H. Aastveit Ingar Holme Curt D. Furberg Allan D. Sniderman | 2004 | Clinical Chemical Laboratory Medicine2004，，12： | 1 |
| 7 | Differential impact of plasma triglycerides on HDL-cholesterol and HDL-apo A-I in a large cohort显示文摘 | André J. Tremblay Allan D. Sniderman Claude Gagné Jean Bergeron Patrick Couture | 2006 | Clinical Biochemistry2006，，1： | 1 |
| 8 | Comparison of the Associations of Apolipoprotein B and Low-Density Lipoprotein Cholesterol With Other Cardiovascular Risk Factors in the Insulin Resistance Atherosclerosis Study (IRAS)显示文摘 | Ken Williams Allan D. Sniderman Naveed Sattar Ralph D’Agostino Lynne E. Wagenknecht Steven M. Haffner | 2003 | Circulation: Journal of the American Heart Association2003，，19： | 1 |
| 9 | The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk显示文摘 | G?ran Walldius Ingmar Jungner Are H. Aastveit Ingar Holme Curt D. Furberg Allan D. Sniderman | 2004 | Clinical Chemical Laboratory Medicine2004，，12： | 1 |
| 10 | Regulation of plasma fatty acid metabolism 显示文摘 | Jumana Saleh Allan D Sniderman Katherine Ciardlone | 1999 | Clinica Chimica Acta1999，286，： | 1 |
| 11 | 年龄是心血管疾病的可变危险因素显示文摘在世界范围内,心血管疾病已成为死亡的主要原因。由于其临床重要性不断增加,因此由预防产生的获益也将随之增加。年龄并不被认为是一个可变的危险因素,但不幸的是,作为临床事件的预测因素,它居于所有危险因素——如血脂、血压和吸烟——之首,如果是这样,那么就存在一个严格的预防年龄范围。但是这一常规的看法是否正确呢? | Allan D Sniderman Curt D Furberg 张选国(译) | 2009 | 世界临床医学2009，3，3： | 0 |
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