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| 1 | Effect of dietary docosahexaenoic acid on lipogenesis and lipolysis in black sea bream,Acanthopagrus schlegeli显示文摘Hatchery-reared juvenile black sea breams are characterized by a low level of highly unsaturated fatty acids in their bodies, as compared with wild fish. To assess the effect of docosahaxaenoic acid (DHA) on lipogenic and lipolysis enzymes, one-year fish were reared on a casein-based purified diet and a DHA fortified diet (1.5% DHA ethyl ester/kg diet) for 60 d, followed with a period of 55 d for starvation. Dietary DHA was effectively incorporated into the fish body. Fortification of DHA depressed activities of glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase as lipogenic enzymes in the hepatopancreas and intraperitoneal fat body. Carnitine palmitoyltransferase as lipolysis enzyme in the hepatopancreas was active in the DHA fortified fish. Starvation after feeding experiment induced increased carnitine palmitoyltransferase activity in both control and DHA fortified fish and the activity remained higher in the DHA fortified fish, while the monoenes were selectively consumed prior to highly unsaturated fatty acids. These results indicated that dietary DHA depressed lipogenesis and activated lipolysis. | JI Hong OM Ahamd Daud YOSHIMATSU Takao UMINO Testuya NAKAGAWA Heisuke FURUHASHI Makoto SAKAMOTO Shuichi | 2007 | Acta Oceanologica Sinica2007，26，1： | 13 |
| 2 | Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis显示文摘We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato- cellular carcinoma (HCC) in a 56-year-old man with alcoholrelated liver cirrhosis. Ultrasound (US) disclosed a 10 mm hypoechoic nodule and contrast enhanced US revealed a hypovascular nodule, both in segment seven. US-guided biopsy revealed a high-grade dysplastic nodule characterized by enhanced cellularity with a high N/C ratio, increased cytoplasmic eosinophilia, and slight cell atypia. One year later, the US pattern of the nodule changed from hypoechoic to hyperechoic without any change in size or hypovascularity. US-guided biopsy revealed well-differentiated HCC of the same features as shown in the first biopsy, but with additional pseudoglandular formation and moderate cell atypia. Moreover, immunohistochemical staining of cyclase- associated protein 2, a new molecular marker of well- differentiated HCC, turned positive. This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis. | Soo Ryang Kim Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，8： | 4 |
| 3 | Minimally invasive surgery for resection of duodenal carcinoid tumors: endoscopic full-thickness resection under laparoscopic observation显示文摘 | Hironori Tsujimoto Takashi Ichikura Shigeaki Nagao Tomoki Sato Satoshi Ono Satoshi Aiko Shuichi Hiraki Yoshihisa Yaguchi Naoko Sakamoto Takemaru Tanimizu Junji Yamamoto Kazuo Hase | 2010 | Surgical Endoscopy2010，，2： | 2 |
| 4 | Non-ossifying fibromas: Case series, including in uncommon upper extremity sites显示文摘AIM To investigate non-ossifying fibromas(NOFs) common fibrous bone lesions in children that occur in bones of the lower extremities.METHODS We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities(1 proximal humerus, 1 distal radius) and the lower extremities(25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas).RESULTS Three cases had NOFs in multiple anatomical locations(femur and fibula in 1 case, femur and tibia in 2 cases). Overall, larger lesions > 4 cm and lesion expansion at the cortex were seen in 21% and 32% of cases, respectively. Multiple lesions with bilateral symmetry in the lower extremities suggest that these NOFs were developmental bone defects. Two patients suffered from fracture and were treated without surgery, one in the radius and one in the femur. Lesions in the upper extremities(i.e., humerus of a 4-year-old female and radius of a 9-year-old male) expanded at the cortex and lesion size increased with slow ossification.CONCLUSION NOFs in the lower extremity had fewer clinical problems, regardless of their size and expansiveness. In these two upper extremity cases, the NOFs had aggressive biological features. It seems that there is a site specific difference, especially between the upper extremity and the lower extremity. Furthermore, NOFs in the radius are predisposed to fracture because of the slender structure of the radius and the susceptibility to stress. | Akio Sakamoto Ryuzo Arai Takeshi Okamoto Shuichi Matsuda | 2017 | World Journal of Orthopedics2017，8，7： | 2 |
| 5 | Outcomes for patients following hepatic resection of metastatic tumors from gastric cancer显示文摘 | Hironori Tsujimoto Takashi Ichikura Satoshi Ono Hidekazu Sugasawa Shuichi Hiraki Naoko Sakamoto Yoshihisa Yaguchi Kazuo Hatsuse Junji Yamamoto Kazuo Hase | 2010 | Hepatology International2010，，1： | 1 |
| 6 | Weekly paclitaxel for heavily treated advanced or recurrent gastric cancer refractory to fluorouracil, irinotecan, and cisplatin显示文摘 | Rai Shimoyama Hirofumi Yasui Narikazu Boku Yusuke Onozawa Shuichi Hironaka Akira Fukutomi Kentaro Yamazaki Keisei Taku Takashi Kojima Nozomu Machida Akiko Todaka Hideharu Tomita Takeshi Sakamoto Takahiro Tsushima | 2009 | Gastric Cancer2009，，4： | 1 |
| 7 | Clinical outcome following surgical intervention for a solitary bone cyst: emphasis on treatment by curettage and steroid injection显示文摘 | Akio Sakamoto Shuichi Matsuda Tatsuya Yoshida Yukihide Iwamoto | 2010 | Journal of Orthopaedic Science2010，，： | 1 |
| 8 | Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis显示文摘 | Yoshikazu Kinoshita Kenji Furuta Norihisa Ishimaura Shunji Ishihara Shuichi Sato Riruke Maruyama Shuichi Ohara Takayuki Matsumoto Choitsu Sakamoto Toshiyuki Matsui Satoshi Ishikawa Tsutomu Chiba | 2013 | Journal of Gastroenterology2013，，3： | 1 |
| 9 | Outcomes for patients following hepatic resection of metastatic tumors from gastric cancer显示文摘 | Hironori Tsujimoto Takashi Ichikura Satoshi Ono Hidekazu Sugasawa Shuichi Hiraki Naoko Sakamoto Yoshihisa Yaguchi Kazuo Hatsuse Junji Yamamoto Kazuo Hase | 2010 | Hepatology International2010，，1： | 1 |
| 10 | Impact of Postoperative Infection on Long-Term Survival After Potentially Curative Resection for Gastric Cancer显示文摘 | Hironori Tsujimoto MD PhD Takashi Ichikura MD PhD Satoshi Ono MD PhD Hidekazu Sugasawa MD Shuichi Hiraki MD Naoko Sakamoto MD Yoshihisa Yaguchi MD Kazumichi Yoshida MD Yusuke Matsumoto MD Kazuo Hase MD PhD | 2009 | Annals of Surgical Oncology2009，，2： | 1 |
| 11 | Effect of Brazilian Propolis on Exacerbation of Respiratory Syncytial Virus Infection in Mice Exposed to TetrabromobisphenolA, a Brominated Flame Retardant显示文摘 | Tomomi Takeshita Wataru Watanabe Satomi Toyama Yuya Hayashi Shiori Honda Shuichi Sakamoto Sayuri Matsuoka Hiroki Yoshida Shiro Takeda Muneaki Hidaka Shigetoshi Tsutsumi Ken Yasukawa Yong Kun Park Masahiko Kurokawa F. R. F. Nascimento | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 12 | Peritoneal computed tomography attenuation values reflect the severity of peritonitis caused by gastrointestinal perforations显示文摘 | Hironori Tsujimoto Yoshihisa Yaguchi Shuichi Hiraki Naoko Sakamoto Isao Kumano Yusuke Matsumoto Kazumichi Yoshida Hidekazu Sugasawa Satoshi Ono Junji Yamamoto Kazuo Hase | 2011 | The American Journal of Surgery2011，，4： | 1 |
| 13 | Well to moderately differentiated HCC manifesting hyperattenuation on both CT during arteriography and arterial portography显示文摘We present a rare case of well-to moderately-differentiated hepatocellular carcinoma (HCC) in a 71-year-old woman with hepatitis C virus-related cirrhosis and unusual radiologic features. A 20-mm hypoechoic nodule disclosed by ultrasound in segment two showed hyperattenuation on both computed tomography hepatic arteriography and computed tomography during arterial portography. Contrast-enhanced ultrasound revealed hypervascularity in the early vascular phase and defect in the post-vascular phase, with the same pattern detected by the two imaging techniques. SPIO-MRI revealed a hyperintense nodule. These findings were compatible with those of moderately-differentiated HCC. An ultrasound-guided biopsy showed histological features of well-to moderately-differentiated HCC characterized by more than two-fold the cellularity of the non-tumorous area, fatty change, clear cell change and mild cell atypia with a thin to mid-trabecular pattern. Further studies may provide insights into the correlation between tumor neovascularity in multistep hepatocarcinogenesis and dual hemodynamics, including the artery and the portal vein. | Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，43： | 0 |
| 14 | System describing surgical field extension associated with flap reconstruction after resection of a superficial malignant soft tissue tumor显示文摘BACKGROUND Flap reconstruction after resection of a superficial malignant soft tissue tumor extends the surgical field and is an indicator for potential recurrence sites.AIM To describe a grading system for surgical field extension of soft tissue sarcomas.METHODS Grading system:CD-grading is a description system consisting of C and D values in the surgical field extension,which are related to the compartmental position of the flap beyond the nearby large joint and deeper extension for the pedicle,respectively.C1/D1 are positive values and C0/D0 are negative.With a known location,1/0 values can be'p'(proximal),'d'(distal),and'b'(in the tumor bed),and the description method is as follows:flap type,CxDx[x=0,1,p,d or b].RESULTS Four representative patients with subcutaneous sarcomas who underwent reconstruction using fasciocutaneous flaps are presented.The cases involved a distal upper arm(elbow)synovial sarcoma reconstructed using a pedicled latissimus dorsi(pedicled flap:CpDp);a distal upper arm(elbow)pleomorphic rhabdomyosarcoma reconstructed using a transpositional flap from the forearm(transpositional flap:CdD0);an undifferentiated pleomorphic sarcoma in the buttocks reconstructed using a transpositional flap(transpositional flap:C0D0);and a myxofibrosarcoma in the buttocks reconstructed using a propeller flap from the thigh(pedicled flap:CdDd).CONCLUSION The reconstruction method is chosen by the surgeon based on size,location,and other tumor characteristics;however,the final surgical field cannot be determined based on preoperative images alone.CD-grading is a description system consisting of C and D values in the surgical field extension that are related to the compartmental position of the flap beyond the nearby large joint and deeper extension for the pedicle,respectively.The CD-grading system gives a new perspective to the flap reconstruction classification.The CD-grading system also provides important information for follow-up imaging of a possible recurrence. | Akio Sakamoto Takashi Noguchi Shuichi Matsuda | 2023 | World Journal of Clinical Oncology2023，14，11： | 0 |
| 15 | New method of local adjuvant therapy with bicarbonate Ringer’s solution for tumoral calcinosis: A case report显示文摘BACKGROUND Tumoral calcinosis is a condition characterized by deposits of calcium phosphate crystals in extra-articular soft tissues,occurring in hemodialysis patients.Calcium phosphate crystals are mainly composed of hydroxyapatite,which is highly infilt-rative to tissues,thus making complete resection difficult.An adjuvant method to remove or resolve the residual crystals during the operation is necessary.CASE SUMMARY A bicarbonate Ringer’s solution with bicarbonate ions(28 mEq/L)was used as the adjuvant.After resecting calcium phosphate deposits of tumoral calcinosis as much as possible,while filling with the solution,residual calcium phosphate deposits at the pseudocyst wall can be gently scraped by fingers or gauze in the operative field.A 49-year-old female undergoing hemodialysis for 15 years had swelling with calcium deposition for 2 years in the shoulders,bilateral hip joints,and the right foot.A shoulder lesion was resected,but the calcification remained and early re-deposition was observed.Considering the difficulty of a complete rection,we devised a bicarbonate dissolution method and excised the foot lesion.After resection of the calcified material,the residual calcified material was washed away with bicarbonate Ringer’s solution.CONCLUSION The bicarbonate dissolution method is a new,simple,and effective treatment for tumoral calcinosis in hemodialysis patients. | Takashi Noguchi Akio Sakamoto Kensaku Kakehi Shuichi Matsuda | 2024 | World Journal of Orthopedics2024，15，3： | 0 |
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