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1电动牙刷与手动牙刷对口腔卫生的效果比较显示文摘目的对电动牙刷和手动牙刷在去除菌斑、维护牙龈健康、对色素和牙结石的作用、可靠性、不良作用和成本等进行比较.方法计算机检索Cochrane口腔健康协作组临床试验资料库(截至2004年6月17日)、Cochran临床对照试验中心资料库(Cochrane图书馆2004第2期)、MEDLINE(1966~2004)、EMBASE(1980~2004第2周)和CINAHL(1982~2004第2周),并与制造商联系以获取更多资料.根据下列标准纳入随机对照试验:随机分配研究对象;参加者为手运动无障碍的普通人群;干预措施为无监督的手动或电动牙刷刷牙,至少4周;主要结局指标为试验期间菌斑和牙龈炎的变化.由6个作者独立评价并纳入研究资料.用随机效应模型进行Meta分析,用标准化均数差(SMD)及其95%CI测量效果.检查可能的异质性来源,并针对研究质量和发表偏倚进行敏感性分析.为便于讨论,将SMD转换为百分率.结果对包含3 855例研究对象的42个试验进行系统评价,结果显示,旋转振动型电动牙刷去除菌斑和减低牙龈炎的效果在短期内明显优于手动牙刷,并在3个月以上的研究中显示降低了牙龈炎指数.在1~3个月的研究中,菌斑SMD为-0.43 [95%CI (-0.72, 0.14)],牙龈炎SMD为-0.62 [95%CI (-0.90, 0.34)],Quigley Hein菌斑指数降低11%,Loe and Silness龈炎指数降低6%.在3个月以上的研究中,菌斑指数SMD为-1.29 [95%CI (-2.67, 0.08)], 龈炎指数为-0.51 [95%CI (-1.76, 0.25)],Ainamo Bay探诊出血指数降低17%.短期研究之间有异质性,敏感性分析显示当选择高质量的研究时结果是肯定的,没有证据表明有发表偏倚.采取其他设计的电动牙刷并不比手动牙刷更优.对成本、可靠性和不良作用的报道不一致,已报道的不良作用都是局限的、暂时的.结论旋转振动型电动牙刷去除牙菌斑、减少牙龈炎的效果优于手动牙刷.遵守方法学指南和更标准化的设计有益于将来的研究和Meta分析.Robinson PG Deacon SA Deery C Heanue M Walmsley AD Worthington HV Glenny AM Shaw WC 陈娥 史宗道 2005中国循证医学杂志2005,5,11:8
2Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis.KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea 2005World Journal of Gastroenterology2005,11,46:7
3卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景 缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 2017国际脑血管病杂志2017,25,5:2
4Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es 2011Antiviral Research2011,,1:2
5血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 2017中华高血压杂志2017,25,12:2
6Resveratrol modulates DNA double strand break repair pathways in an ATM/ATR- p53 and Nbs1-dependent manner显示文摘Gatz SA Keimling M Baumann C 2008Carcinogenesis2008,29,3:1
7Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension显示文摘Lee C Mitsialis SA Aslam M 2012Circulation2012,126,22:1
8Mlgrove syndrome in adulthood 显示文摘Bentes C Santos-Bento M de Sa J 2001Muscle Nerve2001,24,2:1
9Sequence and structure of a human glucose transporter显示文摘Mueckler M Caruso C Baldwin SA 1985Science1985,229,:1
10Archean blocks and their boundaries in the North China Craton: lithological, geochemical, structural and P-T path constraints and tectonic evolution 显示文摘Zhao G C Wilde SA Cawood P A Sun M 2001Precambrian Research2001,107,:1
11Efficiency of the LigaSure vessel sealing system for recipient hepatectomy in liver transplantation 显示文摘Lamattina J C Hosseini M Fayek SA 2013Transplant Proc2013,45,5:1
12Effects of metformin on the glycemic control,lipid profile,and arterial blood pressure of type 2 diabetic patients with metabolic syndrome already on insulin显示文摘Mourao Junior C A Sa J R Guedes O M 2006Braz J Med Biol Res2006,39,4:1
13Organic matter dynamics and carbon sequestration rates for a tillage chronosequence in a Brizilian Oxisol显示文摘De M Sa J C Cerri J C Dick C C 2001Soil Science Society of America Journal2001,65,:1
14Polyacrylamide-g-alginate- based electrically responsive hydrogel for drug delivery application :Synthesis, characterization, and formulation development显示文摘Kulkarni R V Setty C M Sa B 2010Journal of Applied Polymer Science2010,115,2:1
15Relationship among microstructure rheology and processing of a lithium lubri- cating grease显示文摘Delgado M A Sa'nchez M C Valencia C 2005Chemical Engineering Research and Design2005,83,9:1
16Polar vineyard pruning extracts increase the activity of the main ligninolytic enzymes in Lentinula edodes cultures显示文摘HARRIS-VALLE C ESQUEDE M SA NCHEZ A 2007Canadian Journal of Microbiology2007,53,10:1
17The biology of soil compaction 显示文摘HOOEMAN J J SA J C M J REEDER R 2011Soil Tillage Res2011,68,:1
18IL-7 administration to humans leads to expansion of CD8^+ and CD4^+ cells but a relative decrease of CD4^+ T-regulatory cells显示文摘Rosenberg SA Sport s C Ahmadzadeh M 2006J Immunother2006,29,3:1
19Influence of soap concentration and oil viscosity on the rheology and micro- structure of lubricating greases 显示文摘Delgado M A Valencia C Sa'nchez M C 2006Ind Eng Chem Res2006,45,:1
20The management of Graves' disease in children,with special emphasis on radioiodine treatment显示文摘Rivkees SA Sklar C Freemark M 0,,:1
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