|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats显示文摘AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats. | Stanisiaw Ha Marek Dobosz Jan J Kaczor Robert Rzepko Ewa Aleksandrowicz-Wrona Zdzislaw Wajda Zbigniew ledzi■ski Jacek Krajewski | 2005 | World Journal of Gastroenterology2005，11，41： | 7 |
| 2 | Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C显示文摘BACKGROUND: Liver steatosis and iron overload, which are frequently observed in chronic hepatitis C (CHC), may contribute to the progression of liver injury. This study aimed to evaluate the correlation between liver steatosis and iron overload in Polish patients with CHC compared to non- alcoholic fatty liver disease (NAFLD) and HFE-hereditary hemochromatosis (HH) patients. METHODS: A total of 191 CHC patients were compared with 67 NAFLD and 21 HH patients. Liver function tests, serum markers of iron metabolism, cholesterol and triglycerides were assayed. The inflammatory activity, fibrosis, iron deposits and steatosis stages were assessed in liver specimens. HFE gene polymorphisms were investigated by PCR-RFLP. RESULTS: Liver steatosis was associated with obesity and diabetes mellitus. This disease was confirmed in 76/174 (44%) CHC patients, most of whom were infected with genotype 1. The average grade of steatosis was higher in NAFLD patients. CHC patients had significantly higher iron concentrations and transferrin saturations than NAFLD patients. Compared with CHC patients, HH patients had higher values of serum iron parameters and more intensive hepatocyte iron deposits without differences in the prevalence and intensity of liver steatosis. In the CHC group, lipids accumulation in hepatocytes was significantly associated with the presence of serummarkers of iron overload. No correlation between the HFE gene polymorphism and liver steatosis in CHC patients was found. CONCLUSIONS: Liver steatosis was diagnosed in nearly half of CHC patients, most of whom were infected with genotype 1. The intensity of steatosis was lower in CHC patients than that in NAFLD patients because of a less frequent diagnosis of metabolic syndrome. Only in CHC patients were biochemical markers of iron accumulation positively correlated with liver steatosis; these findings were independent of HFE gene mutations. | Katarzyna Sikorska Piotr Stalke Tomasz Romanowski Robert Rzepko Krzysztof Piotr Bielawski | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 2 |
| 3 | Overexpression of cathepsin B correlates with angiogenesis in colon adenocarcinoma显示文摘 | Kruszewski WJ Rzepko R Wojtacki J | 2004 | Neoplasma2004，51，1： | 1 |
| 4 | Meningioangiomatosis with a predominant ilbrocaleifying component 显示文摘 | Izycka-Swieszewska E Rzepko R Kopczynski S | 2000 | Neuropathology2000，20，1： | 1 |
| 5 | Overexpression of cathepsin B correlates with angiogenesis in colon adenocarcinoma显示文摘 | KRUSZEWSKI W J RZEPKO R WOJTACKI J | 2004 | Neoplasma2004，51，1： | 1 |
| 6 | Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumors显示文摘 | Izycka-Swieszewska El Drozyrska E Rzepko R | 2010 | Pol J Patho102010，61，4： | 1 |
| 7 | Analysis of PI3K/AKT/mTOR signalling pathway in high risk neumhlastic tumours显示文摘 | IEYCKA EWIESZEWSKA E DROZYESKA E RZEPKO R | 2010 | Pol J Pathol2010，61，4： | 1 |
| 8 | Identification of high- Risk Stage Ⅱ colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion显示文摘 | Strzelczyk B Szulc A Rzepko R | 2009 | Ann Surg Oncol2009，16，5： | 1 |
| 9 | Region-specific alterations of adenosine receptors expression level in kid- ney of diabetic rat显示文摘 | Pawelczyk T Grden M Rzepko R | 2005 | The American journal of patholo- gy2005，167，2： | 1 |
| 10 | Identification of High-Risk Stage II Colorectal Tumors by Combined Analysis of the NDRG1 Gene Expression and the Depth of Tumor Invasion显示文摘 | Barbara Strzelczyk Aneta Szulc Robert Rzepko Agnieszka Kitowska Jaroslaw Skokowski Andrzej Szutowicz Tadeusz Pawelczyk | 2009 | Annals of Surgical Oncology2009，，5： | 1 |
| 11 | Overexpression of eathepsin B correlates with angiogenesis in colon adenocarcinoma显示文摘 | Kruszewski WJ Rzepko R Wojtacki J | 2004 | Neoplasma2004，51，1： | 1 |
| 12 | Fibrogenesis in fatty liver associated with obesity and diabetes mellitus type 2显示文摘 | Jaskiewicz K Rzepko R Sledzinski Z | 2008 | Dig Dis Sci2008，53，3： | 1 |
| 13 | Recurrent meningioma the immunohistochemical analysis of angiogenesis and cellular proliferation,Preliminary study 显示文摘 | IZYCKA S E RZEPKO R BORIWSK L J | 1999 | Folia Neuropathol1999，37，3： | 1 |
| 14 | 胃成形术治疗肥胖者的非酒精性脂肪性肝病显示文摘Nonalcoholic steatohepatitis (NASH), which is the most severe histologic form of nonalcoholic fatty liver disease (NAFLD), is emerging as the most common clinically important form of liver disease in obese patients. The prevalence of NASH may increase with the rise in the rate of obesity and metabolic syndrome in affluent communities. The aim of this work is to describe clinical and histopathologic findings and correlate liver tissue damage to the length of duration of the obesity in the group of patients who underwent surgery as obesity treatment. Eighty-seven severely or morbidly obese patients underwent gastroplasty. Each patient was evaluated with complete clinical and laboratory medical assessment together with wedge liver biopsy taken from 59 unselected patients during the surgery. Patients were followed up for 41 months. Repeat liver biopsy was taken from 10 patients. Pathologic analysis recorded the presence and degree of steatosis, portal and lobular inflammation and fibrosis. Age, body mass index (BMI), and laboratory assessment correlated with pathologic data. Male patients showed more pronounced metabolic syndrome and fatty liver damage. Patients who become obese in childhood or as teenagers showed no differences in metabolic syndrome and NAFLD in mature age. There was statistically significant association between BMA, elevated transaminases, NAFLD, and fibrosis. Significant weight reduction was observed within first year after surgery,was slower in the second year, and stabilized within third year. Remarkable improvement followed in biological markers of metabolic syndrome. Ninety-six percent of initial liver biopsies had steatosis; 16%developed steatohepatitis and mild perivenular fibrosis. Significant improvement of the degenerative and inflammatory hepatic lesions in repeated biopsies and liver function readings was noted within 8 months after surgery. Obesity is a major and independent risk factor for the metabolic syndrome, NAFLD, NASH, and fibrosis. Surgical treatment improves metabolic abnormalities and hepatic lesions in long-term observations. | Jaskiewicz K. Raczynska S. Rzepko R. Sledziński Z 纪泛扑 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 1 |
| 15 | Immunocytes and activated stellate cells in pancreatic fibrogenesis显示文摘 | Jaskiewicz K Nalecz A Rzepko O | 2003 | Pancreas2003，26，3： | 1 |
| 16 | Identification of high-risk stage II colorectal tumors by combined analy- sis of the NDRG1 gene expression and the depth of tu-mor invasion 显示文摘 | Strzelczyk B Szulc A Rzepko R | 2009 | Ann Surg Oncol2009，16，5： | 1 |
| 17 | Identification of high-risk stage Ⅱ colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion显示文摘 | Strzelczyk B Szulc A Rzepko R | | 0，，05： | 1 |
| 18 | The possible role of factor H in colon cancer resistance to complement attack显示文摘 | WILCZEK E RZEPKO R NOW1S D ct at | 2008 | Int J Cancer2008，122，9： | 1 |
| 19 | Identification of hish-risk stage Ⅱ colorectal tummors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion显示文摘 | Strzelczyk B Szulc A Rzepko A | 2009 | Ann Surg Oncol2009，16，4： | 1 |
| 20 | Overexpression of calhepsin B correlates with angiogenesis in colon adenocarcinoma显示文摘 | Kruszewski W J Rzepko R Wojtacki J | 2004 | Neoplasma2004，51，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员