Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats

查看全文 作　　者：Stanisiaw Ha[1];Marek [2]Dobosz;Jan J [3]Kaczor;Robert [4]Rzepko;Ewa Aleksandrowicz-[5]Wrona;Zdzislaw [6]Wajda;Zbigniew ledzi■[1]ski;Jacek [1]Krajewski

机构地区：[1]Department of General Endocrine and Transplant Surgery Medical University of Gdask,Poland;[2]Department of General and Gastroenterological Surgery St. Vincent a' Paulo Hospital of Gdynia,Poland;[3]Department of Bioenergetics J. niadecki University School of Physical Education in Gdask,Poland;[4]Department of Pathomorphology Medical University of Gdask,Poland;[5]Department of Clinical Nutrition Medical University of Gdask,Poland;[6]Ⅱ Department of General Gastroenterological and Endocrinological Surgery Medical University of Gdask Poland

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第41期,共7页

基　　金：Supported by the grant from Medical University of Gdansk,Poland 摘　　要：AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats. 关键词：嗜中性粒细胞胰腺炎小鼠免疫机制

相关文献

参考文献（16）
引证文献（7）
耦合文献（0）

参考文献(16)

引证文献(7)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats

参考文献(16)

引证文献(7)

用户提示