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您的检索式：作者名="Ruomeng TIAN"
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| 1 | Propagation behavior of SH waves in a piezomagnetic substrate with an orthorhombic piezoelectric layer显示文摘The dispersion behavior of the shear horizontal(SH) waves in the coupled structure consisting of a piezomagnetic substrate and an orthorhombic piezoelectric layer is investigated with different cut orientations. The surface of the piezoelectric layer is mechanically free, electrically shorted, or open, while the surface of the piezomagnetic substrate is mechanically free, magnetically open, or shorted. The dispersion relations are derived for four electromagnetic boundary conditions. The dispersion characteristics are graphically illustrated for the layered structure with the PMN-PT layer perfectly bonded on the CoFe_2O_4 substrate. The effects of the PMN-PT cut orientations, the electromagnetic boundary conditions, and the thickness ratio of the layer to the substrate on the dispersion behavior are analyzed and discussed in detail. The results show that,(i)the effect of the cut orientation on the dispersion curves is very obvious,(ii) the electrical boundary conditions of the PMN-PT layer dominate the propagation feature of the SH waves, and(iii) the thickness ratio has a significant effect on the phase velocity when the wave number is small. The results of the present paper can provide valuable theoretical references to the applications of piezoelectric/piezomagnectic structure in acoustic wave devices. | Yanping KONG Ruomeng TIAN Jie XU Jinxi LIU | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，2： | 0 |
| 2 | Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease显示文摘Background:Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer’s disease(AD).Melatonin has been shown to prevent tau hyperphosphorylation in cellular and animal models.However,the molecular mechanisms by which melatonin attenuates tau hyperphosphorylation and tau-related pathologies are not fully understood.Methods:Immunofluorescence,immunoblotting analysis and thioflavin-S staining were employed to examine the effects of early and late treatment of melatonin on tau-related pathology in hTau mice,in which nonmutated human tau is overexpressed on a mouse tau knockout background.High-throughput microRNA(miRNA)sequencing,quantitative RT-PCR,luciferase reporter assay and immunoblotting analysis were performed to determine the molecular mechanism.Results:We found that both early and late treatment of melatonin efficiently decreased the phosphorylation of soluble and insoluble tau at sites related to AD.Moreover,melatonin significantly reduced the number of neurofibrillary tangles(NFTs)and attenuated neuronal loss in the cortex and hippocampus.Furthermore,using miRNA microarray analysis,we found that miR-504-3p expression was upregulated by melatonin in the hTau mice.The administration of miR-504-3p mimics dramatically decreased tau phosphorylation by targeting p39,an activator of the well-known tau kinase cyclin-dependent kinase 5(CDK5).Compared with miR-504-3p mimics alone,co-treatment with miR-504-3p mimics and p39 failed to reduce tau hyperphosphorylation.Conclusions:Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR-504-3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies. | Dongmei Chen Guihua Lan Ruomeng Li Yingxue Mei Xindong Shui Xi Gu Long Wang Tao Zhang Chen-Ling Gan Yongfang Xia Li Hu Yuan Tian Mi Zhang Tae Ho Lee | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
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