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| 1 | Enhanced performance of GaN nanobelt-based photodetectors by means of piezotronic effects显示文摘轧紫外(紫外) 光电探测器(PD ) 在严厉环境由于他们的化学稳定性吸引了巨大的注意。尽管联系 Schottky 的基于陷阱的紫外 PD 比欧姆的接触的与更好的性能被实现了,在本地 Schottky 接触的障碍高度怎么控制传感器表演,仍然保持未知。在这个工作, piezotronic 效果被采用在本地接触调节 Schottky 障碍高度(SBH ) 并且因此提高组织的联系 Schottky 的 metal-semiconductor-metal (MSM ) 的表演轧了基于的 nanobelt (NB ) PD。一般来说,当在设备上使用紧张时, PD 的反应水平被 piezotronic 效果显然提高。PD 的 responsivity 被 18% 增加,并且敏感被提高由从 22% ~ 31% ,当与轻紧张从 12 ~ 2 W/cm2 由 325 nm 激光照亮了时。小心地用乐队结构图学习机制表明 PD 表演的观察改进从变化导致了外部紧张以及轻紧张引起的 SBH。使用 piezotronic 效果因此提供一个实际方法提高由做的 PD 的表演不仅轧,而且另外的 wurtzite 和锌闪锌矿家庭材料。 | Ruomeng Yu Caofeng Pan Youfan Hu Lin Li Hongfei Liu Wei Liu Soojin Chua Dongzhi Chi Zhong Lin Wang | 2013 | Nano Research2013，6，10： | 6 |
| 2 | Degradation strategies of pesticide residue:From chemicals tosynthetic biology显示文摘The past 50 years have witnessed a massive expansion in the demand and application of pesticides.However,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many aspects.To aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment,chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a pollution.In recent years,bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide degradation.Combining the customized design strategy and standardized assembly mode,the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue degradation.This review introduces the mechanisms and hazards of different pesticides,summarizes the methods applied in the degradation of pesticide residues,and discusses the advantages,applications,and prospects of synthetic biology in degrading pesticide residues. | Bi Ruomeng Ou Meihao Zhou Siru Geng Shichen Zheng Yixian Chen Junhong Mo Ruijie Li Yuan Xiao Gezhi Chen Xingyu Zhai Shiyi Zhang Aihui Fang Baishan | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 3 | Lung microbiome:new insights into the pathogenesis of respiratory diseases显示文摘The lungs were long thought to be sterile until technical advances uncovered the presence of the lung microbial community.The microbiome of healthy lungs is mainly derived from the upper respiratory tract(URT)microbiome but also has its own characteristic flora.The selection mechanisms in the lung,including clearance by coughing,pulmonary macrophages,the oscillation of respiratory cilia,and bacterial inhibition by alveolar surfactant,keep the microbiome transient and mobile,which is different from the microbiome in other organs.The pulmonary bacteriome has been intensively studied recently,but relatively little research has focused on the mycobiome and virome.This up-to-date review retrospectively summarizes the lung microbiome’s history,composition,and function.We focus on the interaction of the lung microbiome with the oropharynx and gut microbiome and emphasize the role it plays in the innate and adaptive immune responses.More importantly,we focus on multiple respiratory diseases,including asthma,chronic obstructive pulmonary disease(COPD),fibrosis,bronchiectasis,and pneumonia.The impact of the lung microbiome on coronavirus disease 2019(COVID-19)and lung cancer has also been comprehensively studied.Furthermore,by summarizing the therapeutic potential of the lung microbiome in lung diseases and examining the shortcomings of the field,we propose an outlook of the direction of lung microbiome research. | Ruomeng Li Jing Li Xikun Zhou | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 4 | Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease显示文摘Background:Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer’s disease(AD).Melatonin has been shown to prevent tau hyperphosphorylation in cellular and animal models.However,the molecular mechanisms by which melatonin attenuates tau hyperphosphorylation and tau-related pathologies are not fully understood.Methods:Immunofluorescence,immunoblotting analysis and thioflavin-S staining were employed to examine the effects of early and late treatment of melatonin on tau-related pathology in hTau mice,in which nonmutated human tau is overexpressed on a mouse tau knockout background.High-throughput microRNA(miRNA)sequencing,quantitative RT-PCR,luciferase reporter assay and immunoblotting analysis were performed to determine the molecular mechanism.Results:We found that both early and late treatment of melatonin efficiently decreased the phosphorylation of soluble and insoluble tau at sites related to AD.Moreover,melatonin significantly reduced the number of neurofibrillary tangles(NFTs)and attenuated neuronal loss in the cortex and hippocampus.Furthermore,using miRNA microarray analysis,we found that miR-504-3p expression was upregulated by melatonin in the hTau mice.The administration of miR-504-3p mimics dramatically decreased tau phosphorylation by targeting p39,an activator of the well-known tau kinase cyclin-dependent kinase 5(CDK5).Compared with miR-504-3p mimics alone,co-treatment with miR-504-3p mimics and p39 failed to reduce tau hyperphosphorylation.Conclusions:Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR-504-3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies. | Dongmei Chen Guihua Lan Ruomeng Li Yingxue Mei Xindong Shui Xi Gu Long Wang Tao Zhang Chen-Ling Gan Yongfang Xia Li Hu Yuan Tian Mi Zhang Tae Ho Lee | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
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