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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Three-dimensional porous graphene sponges assembled with the combination of surfactant and freeze-drying显示文摘与表面活化剂和 freeze-drying 的联合,我们开发了二种 graphene 多孔的结构。在一方面,把肥皂水泡的泡沫用作模板,有富有的层次毛孔的三维的多孔的 graphene 海绵被综合了。材料的毛孔包含长度规模的三个层次,包括毫米,测微计和纳米。结构能被改变结冰媒介调节,调整激动人心的率或增加功能的添加剂。由 graphene 氧化物 / 表面活化剂暂停的直接 freeze-drying,在另一方面,有方向性地排列的毛孔的一个多孔的框架被准备。表面活化剂给 graphene 氧化物表的更好的分散,导致一个高特定的表面区域。两个获得的材料展出优秀吸收能力和好压缩性能,提供大量可能的应用程序,例如吸收剂,存储媒介,和搬运人。 | Rujing Zhang Yachang Cao Peixu Li Xiaobei Zang Pengzhan Sun Kunlin wang Minlin Zhong Jinquan Wei Dehai Wu Feiyu Kang Hongwei Zhu | 2014 | Nano Research2014，7，10： | 10 |
| 3 | Sponge-like nickel phosphide-carbon nanotube hybrid electrodes for efficient hydrogen evolution over a wide pH range显示文摘经由水的电解的划算的氢生产为氢进化反应要求有效、持久的地球丰富的催化剂(她的) 在一个宽 pH 范围上。此处,我们报导像海绵的镍磷化物碳 nanotube (Ni x P/CNT ) 被非结晶的 Ni x P 催化剂到 threedimensional (3D ) 上多孔的 CNT 支持。这些混合物在酸、中立、基本的媒介为持续的氢进化展出优异催化活动。特别地, Ni x P/CNT 电极产生 10 和 100 mAapy 的 cathodic 水流,但是总是 regressed onanticoagulation。传单限制和最大的厚度的功课在二个组之间是显著地不同的( P ? P ?=? 0.005 )并且传单限制分数由一中部 1 [ quartiles 0 ; 2 ]( P ?=? 0.013 ),而在 anticoagulation 组,在 2.57 的最大的厚度 regressed ?甘油的 n 作为副产品。最后的紧张生产了 9.8 ? l 33 ?%( 从 205 ~ 272 ? mg/L ) 。直角的策略 inte?? | Shuying Wang Li Zhang Xiao Li Changli Li Rujing Zhang Yingjiu Zhang Hongwei Zhu | 2017 | Nano Research2017，10，2： | 8 |
| 4 | Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition显示文摘为健全信号获得和识别的一个便携、高精确的传感器从编织的特殊设计的 graphene 的薄电影被制作织物(GWF ) 。在被拉长之上,随机的裂缝的高密度出现在网络,它减少当前的小径,从而增加电阻。因此,这部电影能对人的喉咙作为一个紧张传感器起作用以便测量通过肌肉运动,一个声音是否被生产的讲话。超离频敏感允许由提取声波的签名特征的快速、低频率的讲话采样的实现。在这研究, 26 封英语信,典型汉字和音调的代表性的信号,甚至短语和句子被测试,揭示在电阻的明显、典型的变化。而且, graphene 传感器的电阻变化与预告录下的声音完美地反应了。由把人工智能与数字信号处理相结合,我们期望以后,这个 graphene 传感器将能成功地达成复杂声学的系统和听觉的数据的大数量。 | Yan Wang Tingting Yang Junchao Lao Rujing Zhang Yangyang Zhang Miao Zhu Xiao Li Xiaobei Zang Kunlin Wang Wenjian YU Hu Jin Li Wang Hongwei Zhu | 2015 | Nano Research2015，8，5： | 8 |
| 5 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 6 | Controllable preparation and microwave absorption properties of shape anisotropic Fe_(3)O_(4) nanobelts显示文摘To substantially prevent electromagnetic threatens,microwave absorbing materials(MAMs)are required to eliminate surplus electromagnetic waves.As a typical MAM,Fe_(3)O_(4) particles with complex permittivity and permeability have been widely applied due to the coexistence of magnetic loss and dielectric loss.However,the necessary high mass fraction significantly limited its applications,thus Fe_(3)O_(4) nanostructures have been extensively investigated to overcome this problem.In this work,uniform Fe_(3)O_(4) nanobelts were prepared by electrospinning and two-step thermal treatment.By controlling the composition and viscosity of the electrospinning precursor solution,Fe_(3)O_(4) nanobelts with tunable lateral sizes(200 nme1 mm)were obtained.The samples with low content(only 16.7 wt%)Fe_(3)O_(4) exhibited wide maximum effective absorbing bandwidths(EAB)over 3 GHz,and Fe_(3)O_(4) nanobelts with smaller lateral sizes showed a maximum EAB of 4.93 GHz.Meanwhile,Fe_(3)O_(4) nanobelts with smaller lateral sizes presented superior reflection loss properties,the lowest reflection loss reached-53.93 dB at 10.10 GHz,while the maximum EAB was up to 2.98 GHz.The excellent microwave reflection loss of Fe_(3)O_(4) nanobelts was contributed to the enhanced synergistic effect of magnetic loss,dielectric loss,and impedance matching,originated from the hierarchically cross-linked networks and shape anisotropies.This study could broaden the practical applications of magnetic absorbers,and provided an approach for the development of shape anisotropic magnetic materials. | Jialiang Pan Rujing Zhang Jun Ling Min Wang Zechen Li Zhen Zhen Limin He Hongwei Zhu | 2021 | Journal of Materiomics2021，7，5： | 3 |
| 7 | Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis显示文摘RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers.However,efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging.Recently,more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating.Due to the flexibility and deformability of nucleic acids,the nanoassemblies could be fabricated with different shapes and structures.With hybridization,nucleic acid nanoassemblies,including DNA and RNA nanostructures,can be applied to enhance RNA therapeutics and diagnosis.This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development. | Mengnan Zhao Rujing Wang Kunmeng Yang Yuhong Jiang Yachen Peng Yuke Li Zhen Zhang Jianxun Ding Sanjun Shi | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 8 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 9 | Simultaneous determination of Repaglinide and Irbesartan in biological plasmas using micellar enhanced excitation-emission matrix fluorescence coupled with ATLD method显示文摘A highly sensitive and selective 3D excitation-emission fluorescence method has been proposed to rapidly quantify the combined antidiabetics Repaglinide(Re) and Irbesartan(Ir) in rat and human plasmas with the aid of second-order calibration method based on alternating trilinear decomposition(ATLD) method. Re and Ir with weak fluorescence can be endowed with strong fluorescent property by changing the microenvironment in samples and improving the fluorescence quantum yield by using an appropriate micellar enhanced surfactant. The enhanced excitation-emission matrix fluorescence of Re and Ir can be accurately resolved and can simultaneously attain the optimal concentration even in the presence of a potentially strong intrinsic fluorescence from complex biological matrices, such as rat and human plasmas, by using the ATLD method, which completely exploits the 'second-order advantage'. The average recoveries of Re and Ir obtained from ATLD with the factor number of 3(N=3) were 101.0%±4.3% and 99.1%±4.1% for rat plasma and 100.5%±5.4% and 97.1%±3.6% for human plasma. Several statistical methods, including Student's t-test, figures of merit, and elliptical joint confidence region, have been utilized to evaluate the accuracy of the proposed method. Results show that the developed method can maintain second-order advantage in simultaneous determinations of the weak fluorescent analytes of interest in different biological plasma matrices. | Haiyan Fu Hedong Li Mei Shao Tianming Yang Xu Zhang Rujing Xu Yujuan Wei Shuhua Chen Chuang Ni Hailong Wu | 2016 | Science China Chemistry2016，59，7： | 1 |
| 10 | A Model for Representing and Reasoning of Topological Relations of Multiple Simple Regions显示文摘There are representative models for spatial topological relations of Region connection calculus and intersections model.The purpose of this paper is to study the topological relations of multiple simple regions.In this paper,the 4-intersection matrix model is extended into a2n-intersection representative function model to represent the spatial relations of multiple simple regions.The exclusiveness and the completeness of these topological relations are proved.Moreover,this paper also gives detailed discussion on the properties and applications of this model from a special and new perspective.And the topological relations among three simple regions in this paper are applied to forecast the impact of typhoon on the specified target areas.Compared with the extended 4-intersection model,8-intersection cube model is more elaborate in representing the topological relations among the three simple regions. | LI Jian WEN Changji YAO Rujing WU Lin | 2017 | Chinese Journal of Electronics2017，26，5： | 1 |
| 11 | An Analysis on the Forestry Technology Work after Afforestation显示文摘In recent years,the concept of'Lucid waters and lush mountains are invaluable assets'has been deeply rooted in the hearts of the people,however,China is still a country with little forest and fragile ecology.This paper expounds the present situation of environmental protection in China,analyzes the main problems and deficiencies in afforestation,puts forward the function of afforestation construction,and makes strategic thinking on environmental protection and afforestation work. | Yulong SHI Xue LI Rujing YANG Jin HUANG Yi ZHANG | 2020 | Asian Agricultural Research2020，12，6： | 0 |
| 12 | Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease:a phaseⅠ/Ⅱclinical trial显示文摘Background There have been no effective treatments for slowing or reversing Alzheimer’s disease(AD)until now.Growing preclinical evidence,including this study,suggests that mesenchymal stem cells-secreted exosomes(MSCs-Exos)have the potential to cure AD.Aims The first three-arm,drug-intervention,phase I/II clinical trial was conducted to explore the safety and efficacy of allogenic human adipose MSCs-Exos(ahaMSCs-Exos)in patients with mild to moderate AD.Methods The eligible subjects were assigned to one of three dosage groups,intranasally administrated with ahaMSCs-Exos two times per week for 12 weeks,and underwent follow-up visits at weeks 16,24,36 and 48.Results No adverse events were reported.In the medium-dose arm,Alzheimer’s Disease Assessment Scale–Cognitive section(ADAS-cog)scores decreased by 2.33(1.19)and the basic version of Montreal Cognitive Assessment scores increased by 2.38(0.58)at week 12 compared with baseline levels,indicating improved cognitive function.Moreover,the ADAS-cog scores in the medium-dose arm decreased continuously by 3.98 points until week 36.There were no significant differences in altered amyloid or tau deposition among the three arms,but hippocampal volume shrank less in the medium-dose arm to some extent.Conclusions Intranasal administration of ahaMSCs-Exos was safe and well tolerated,and a dose of at least 4×10^(8)particles could be selected for further clinical trials. | Xinyi Xie Qingxiang Song Chengxiang Dai Shishuang Cui Ran Tang Suke Li Jing Chang Ping Li Jintao Wang Jianping Li Chao Gao Hongzhuan Chen Shengdi Chen Rujing Ren Xiaoling Gao Gang Wang | 2023 | General Psychiatry2023，36，5： | 0 |
| 13 | Constructing 2D ultrathin graphene oxide membranes with supramolecular-assembled nano-adhesives for enhancing water stability显示文摘Atomic-thick two-dimensional(2D)graphene oxide(GO)has emerged as an ideal building block in developing ultrathin 2D membranes for separating substances.However,due to the negative charge of GO sheets when hydrated,electrostatic repulsion causes GO membranes to disintegrate easily in water,limiting their wide application in aqueous solutions.Here,we introduce and apply the concept of localized gluing by designing ultra-small supramolecular-assembled nanoparticles as nanoadhesives(NPA)to construct robust GO membranes with a thickness of only 24 nm.The supramolecular-assembled NPA were synthesized by cyclodextrin(CD)and tannic acid(TA)with a uniform size distribution of about 4.5 nm,and exposed surface pyrogallols that could strongly interact with GO sheets.The physical sizing of the NPA confines the interlayer spacing and maintains the nanochannel,while the natural molecular properties of the NPA enhance the connection between adjacent layers and inhibit swelling detachment.The fabricated ultrathin 2D membranes show a remarkable two times enhancement of water permeance over pristine GO membranes and exhibit excellent durability with record-breaking stability for 720 h immersion in water.This strategy provides meaningful insights into the design and fabrication of robust ultrathin membranes for practical application. | Wei Liu Yuan Li Rujing Li Hui Xu Xinling Lu Weibing Dong Zhen Zhang Yong Wang | 2023 | Nano Research2023，16，7： | 0 |
| 14 | SparkLink:A short-range wireless communication protocol with ultra-low latency and ultra-high reliability显示文摘Dear Editor,Short-range wireless communications have been widely used in our daily life,but the pursuit of a better communication experience never stops,leading to the more stringent requirements of emerging applications.^(1)For example,remote control applications such as telesurgery require a delay of less than 1 ms.^(2)Indus-trial closed-loop control applications such as automatic assembly lines have a reliability requirement of at least 99.999%. | Mingjin Gao Lei Wan Rujing Shen Yongqiang Gao Jian Wang Yonghui Li Branka Vucetic | 2023 | The Innovation2023，4，2： | 0 |
| 15 | E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease显示文摘Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic AD.Here,a novel missense mutation,APP E674Q(also named“Shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his mid-70s.The results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied Swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in silico.Molecular dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by BACE1.The in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.Furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J mice.AAV-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical Swedish mutation.Collectively,we report a strong amyloidogenic effect of the E674Q substitution in AD.To our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD. | Yongfang Zhang Xinyi Xie Boyu Chen Lina Pan Jianping Li Wanbing Wang Jintao Wang Ran Tang Qiang Huang Xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
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