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| 1 | Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery显示文摘For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system yet could mimic both controlled basal insulin release and rapid prandial insulin release in response to real-time blood glucose changes. Here we reported an artificial insulin delivery system, mimicking physiological basal and prandial insulin secretion, to achieve real-time glycemic control and reduce risk of hypoglycemia. A phenylboronic acid(PBA)/galactosyl-based glucose-responsive insulin delivery system was prepared with insulin-loaded micelles embedded in hydrogel matrix. At the hyperglycemic state, both the hydrogel and micelles could swell and achieve rapid glucose-responsive release of insulin, mimicking prandial insulin secretion.When the glucose level returned to the normal state, only the micelles partially responded to glucose and still released insulin gradually. The hydrogel with increased crosslinking density could slow down the diffusion speed of insulin inside, resulting in controlled release of insulin and simulating physiological basal insulin secretion. This hydrogel-micelle composite insulin delivery system could quickly reduce the blood glucose level in a mouse model of type 1 diabetes, and maintain normal blood glucose level without hypoglycemia for about 24 h. This kind of glucose-responsive hydrogel-micelle composite may be a promising candidate for delivery of insulin in the treatment of diabetes. | Juan Lv Gang Wu Ying Liu Chang Li Fan Huang Yumin Zhang Jinjian Liu Yingli An Rujiang Ma Linqi Shi | 2019 | Science China Chemistry2019，62，5： | 5 |
| 2 | Optic and catalytic properties of gold nanoparticles tuned by homopolymers显示文摘Gold nanoparticles (GNs) are prepared through in situ reduction using NaBH4 in the presence of homopolymer PDMAEMA. The sizes of the GNs can be adjusted by alternating the molar ratio of gold to DMAEMA. Pure PDMAEMA aqueous solution shows a phase-transition at 50℃ at pH 10 and 25℃ at pH 14, while PDMAEMA-supported GNs aqueous solution shows a phase-transition at 47℃ at pH 10 because of the increasing hydrophobic property resulting from GNs. Due to the pH and tempera-ture-responsible characteristics of PDMAEMA, the resulting PDMAEMA-supported GNs exhibit pH adjustable temperature-responsive characteristics in optic and catalytic aspects. Under an acidic condi-tion (pH 2), the GNs show unchanged surface Plasmon absorbance with a peak of 518 nm in a tem-perature range from 20 to 65℃. Under a basic condition (pH 10), the GNs first show the same absorb-ance with a peak at 518 nm in a temperature range from 20 to 40℃, and then the absorbance red shifts from 518 to 545 nm as temperature increases from 40 to 65℃. When the GNs are used as catalysts to catalyze the reduction of p-nitrophenol, the catalytic activity can be adjusted by changing the permeation of reactants in the PDMAEMA layer at low and high temperatures, respectively. | CHEN Xi ZHAO DongYun ZHAO LiZhi AN YingLi MA RuJiang SHI LinQi HE QiJun CHEN Li | 2009 | Science China Chemistry2009，52，9： | 3 |
| 3 | Formation of complex micelles with double-responsive channels from self-assembly of two diblock copolymers 显示文摘 | Li Guiying Shi Linqi Ma Rujiang | 2006 | Angewandte Chemic-International Edition2006，45，30： | 1 |
| 4 | Keith J Propagation of PAMAM dendrons on silica Gel:a study on the reaction kinetics显示文摘 | Bu Jie Li Rujiang Quah Chee Wee | 2004 | Macromolecules2004，19，： | 1 |
| 5 | Criteria for intermittent and continuous disturbance transition of ERA interaction with shaped charge jet显示文摘There are two interaction mechanisms between shaped charge jet and thin flying plate driven by explosion, that is, the intermittent and continuous disturbance. Determination of the transition criteria for the intermittent and continuous disturbance is of importance for the penetration calculation of the escaping jet and the design of ERA(explosive reactive armour). In this paper a new criteria was presented based on the analysis of interaction process, and the effects of NATO angle and thickness of flying plate on the disturbance frequency were discussed. It is shown that the critical shaped charge jet velocity increases with the plate thickness and NATO angle, especially increases drastically between 45° and 60°. | Li Rujiang Shen Zhaowu | 2008 | Engineering Sciences2008，6，3： | 0 |
| 6 | Negative refraction of ultra-squeezed in-plane hyperbolic designer polaritons显示文摘The in-plane negative refraction of high-momentum(i.e.,high-k)photonic modes could enable many applications such as imaging,focusing,and waveguiding in a planar platform at deep-subwavelength scales.However,its practical implementation in experiments remains elusive so far.Here we propose a class of hyperbolic metasurfaces,which is characterized by an anisotropic magnetic sheet conductivity and can support the in-plane ultrahigh-k magnetic designer polaritons.Based on such metasurfaces,we report the experimental observation of the all-angle negative refraction of designer polaritons at extremely deep-subwavelength scales.Moreover,we directly visualize the designer polaritons with hyperbolic dispersions.Importantly,for these hyperbolic polaritons,we find that their squeezing factor is ultra-large.To be specific,it can be up to 129 in the experiments,an ultra-high value exceeding those in naturally hyperbolic materials.This work may pave a way toward exploring the extremely high confinement and unusual propagation of magnetic designer polaritons over monolayer or twisted bilayer hyperbolic metasurfaces. | QIAOLU CHEN YIHAO YANG LI ZHANG JIALIN CHEN MIN LI XIAO LIN RUJIANG LI ZUOJIA WANG BAILE ZHANG HONGSHENG CHEN | 2021 | Photonics Research2021，9，8： | 0 |
| 7 | Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation显示文摘New antimicrobial strategies are urgently needed to meet the challenges posed by the emergence of drug-resistant bacteria and bacterial biofilms.This work reports the facile synthesis of antimicrobial dynamic covalent nano-networks(aDCNs)composing antibiotics bearing multiple primary amines,polyphenols,and a cross-linker acylphenylboronic acid.Mechanistically,the iminoboronate bond drives the formation of aDCNs,facilitates their stability,and renders them highly responsive to stimuli,such as low pH and high H2O2 levels.Besides,the representative A1B1C1 networks,composed of polymyxin B1(A1),2-formylphenylboronic acid(B1),and quercetin(C1),inhibit biofilm formation of drug-resistant Escherichia coli,eliminate the mature biofilms,alleviate macrophage inflammation,and minimize the side effects of free polymyxins.Excellent bacterial eradication and inflammation amelioration efficiency of A1B1C1 networks are also observed in a peritoneal infection model.The facile synthesis,excellent antimicrobial performance,and biocompatibility of these aDCNs potentiate them as a much-needed alternative in current antimicrobial pipelines. | Yuanfeng Li Yin-Zi Piao Hua Chen Keqing Shi Juqin Dai Siran Wang Tieli Zhou Anh-Tuan Le Yaran Wang Fan Wu Rujiang Ma Linqi Shi Yong Liu | 2023 | Bioactive Materials2023，，9： | 0 |
| 8 | Ideal type-Ⅱ Weyl points in topological circuits显示文摘Weyl points(WPs),nodal degenerate points in three-dimensional(3D)momentum space,are said to be'ideal'if they are symmetry-related and well-separated,and reside at the same energy and far from nontopological bands.Although type-II WPs have unique spectral characteristics compared with type-I counterparts,ideal type-II WPs have not yet been reported because of a lack of an experimental platform with enough flexibility to produce strongly tilted dispersion bands.Here,we experimentally realize a topological circuit that hosts only topological bands with a minimal number of four ideal type-II WPs.By stacking two-dimensional(2D)layers of inductor-capacitor(LC)resonator dimers with the broken parity inversion symmetry(P),we achieve a strongly tilted band structure with two group velocities in the same direction,and topological surface states in an incomplete bandgap.Our results establish an ideal system for the further study of Weyl physics and other exotic topological phenomena. | Rujiang Li Bo Lv Huibin Tao Jinhui Shi Yidong Chong Baile Zhang Hongsheng Chen | 2021 | National Science Review2021，8，7： | 0 |
| 9 | Self-assembled nanochaperones enable the disaggregation of amyloid insulin fibrils显示文摘The deposition of highly ordered amyloid fibrils is recognized as a hallmark of amyloidosis diseases such as Alzheimer’s disease and Parkinson’s disease.Disaggregating the amyloid fibrils is considered as one of the effective strategies for the control and treatment of amyloidosis diseases.In this article,by simulating the function of natural molecular chaperones,co-assembled block copolymer micelles with coordination groups of nitrilotriacetic acid(NTA)and hydrophobic microdomains of poly(Nisopropylacrylamide)(PNIPAM)on the surface were used as nanochaperones(n Chaps)to disaggregate amyloid insulin fibrils.Zinc ions chelated by NTA can bind the histidine imidazole residues while the PNIPAM microdomains can interact with the exposed hydrophobic sites on the amyloid insulin fibrils,which synergistically perturb the stability of amyloid insulin fibrils,loosen their structure,and finally promote their disaggregation.A combination of characterizations with fluorescence spectroscopy,transmission electron microscopy(TEM),dynamic hight scattering(DLS),and quartz crystal microbalance(QCM)demonstrated that mature amyloid insulin fibrils were completely disaggregated after incubating with n Chaps for 90 h.This study may provide a promising strategy for the development of n Chaps for the treatment of amyloidosis diseases. | Hui Wang Ang Li Menglin Yang Yu Zhao Linqi Shi Rujiang Ma | 2022 | Science China Chemistry2022，65，2： | 0 |
| 10 | Protein@PP-Zn nanocomplex assembled by coordination of zinc ions used for intracellular protein delivery显示文摘In recent years,intracellular delivery of protein drugs has attracted great attention,and polymer-based systems have been extensively exploited to develop efficient and safe carriers.However,efficient intracellular delivery of protein drugs remains a challenge because of the cell membrane barrier and endosome entrapment.Herein,we report a protein@PP-Zn nanocomplex,which consists of an imidazole-containing block polymer poly(ethylene glycol)-block-poly(β-amino ester)(PEG-b-PAE(Im),PP),zinc ions,and protein drugs,for efficient intracellular protein delivery.PEG-b-PAE(Im)could conjugate proteins via the bridging effect of zinc ions which simultaneously coordinate with imidazole groups on polymer and electron donor groups,such as imidazole and primary amine groups,on protein to improve the loading stability of proteins.Under a slightly acidic environment near cancer cells,the protonation of PAE(Im)backbone increases the positive charge density of the nanocomplex and promotes endocytosis.While under a more acidic environment in endosomes,further protonation of imidazole groups leads to the disintegration of the nanocomplex and the breakdown of endosomes because of the proton sponge effect.Finally,protein is released into the cytoplasm.With the assistance of the nanocomplex,proteins with different sizes and isoelectric points are effectively delivered into cells.This work provides a stable,efficient and universal strategy for intracellular protein delivery. | Liyun Cui Sainan Liu Fan Wu Hua Chen Yuanfeng Li Linqi Shi Yong Liu Rujiang Ma | 2023 | Science China Chemistry2023，66，8： | 0 |
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