|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA显示文摘HBV infection initiates hepatitis B and promotes liver cirrhosis and hepatocellular carcinoma.IFN-α is commonly used in hepatitis B therapy,but how it inhibits HBV is not fully understood.We screened 285 human interferon-stimulated genes(ISGs)for anti-HBV activity using a cell-based assay,which revealed several anti-HBV ISGs.Among these ISGs,SAMD4A was the strongest suppressor of HBV replication.We found the binding site of SAMD4A in HBV RNA,which was a previously unidentified Smaug recognition region(SRE)sequence conserved in HBV variants.SAMD4A binds to the SRE site in viral RNA to trigger its degradation.The SAM domain in SAMD4A is critical for RNA binding and the C-terminal domain of SAMD4A is required for SAMD4A anti-HBV function.Human SAMD4B is a homolog of human SAMD4A but is not an ISG,and the murine genome encodes SAMD4.All these SAMD4 proteins suppressed HBV replication when overexpressed in vitro and in vivo.We also showed that knocking out the Samd4 gene in hepatocytes led to a higher level of HBV replication in mice and AAV-delivered SAMD4A expression reduced the virus titer in HBVproducing transgenic mice.In addition,a database analysis revealed a negative correlation between the levels of SAMD4A/B and HBV in patients.Our data suggest that SAMD4A is an important anti-HBV ISG for use in IFN therapy of hepatitis B and that the levels of SAMD4A/B expression are related to HBV sensitivity in humans. | Yuze Wang Xinrui Fan Yunlong Song Yifei Liu Ruixin Liu Jianfeng Wu Xiaoling Li Quan Yuan Guo Fu Ningshao Xia Jiahuai Han | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 2 | Neighboring Atom Collisions in Solid-State High Harmonic Generation显示文摘High harmonic generation(HHG)from solids shows great application prospects in compact short-wavelength light sources and as a tool for imaging the dynamics in crystals with subnanometer spatial and attosecond temporal resolution.However,the underlying collision dynamics behind solid HHG is still intensively debated and no direct mapping relationship between the collision dynamics with band structure has been built.Here,we show that the electron and its associated hole can be elastically scattered by neighboring atoms when their wavelength approaches the atomic size.We reveal that the elastic scattering of electron/hole from neighboring atoms can dramatically influence the electron recombination with its left-behind hole,which turns out to be the fundamental reason for the anisotropic interband HHG observed recently in bulk crystals.Our findings link the electron/hole backward scattering with Van Hove singularities and forward scattering with critical lines in the band structure and thus build a clear mapping between the band structure and the harmonic spectrum.Our work provides a unifying picture for several seemingly unrelated experimental observations and theoretical predictions,including the anisotropic harmonic emission in MgO,the atomic-like recollision mechanism of solid HHG,and the delocalization of HHG in ZnO.This strongly improved understanding will pave the way for controlling the solid-state HHG and visualizing the structure-dependent electron dynamics in solids. | Ruixin Zuo Alexander Trautmann Guifang Wang Wolf-Rüdiger Hannes Shidong Yang Xiaohong Song Torsten Meier Marcelo Ciappina Huynh Thanh Duc Weifeng Yang | 2021 | Ultrafast Science2021，，1： | 0 |
| 3 | Electrospun Bi-decorated Bi_(x)Ti_(y)O_(z)/TiO_(2) flexible carbon nanofibers and their applications on degradating of organic pollutants under solar radiation显示文摘Presently,photocatalytic degradation has emerged as an attractive and efficient technology for wastewater treatment.In order to avoid hurdles,such as difficulty in the suspended photocatalyst segregation from the aqueous system and low reutilization rate,the strategy of immobilizing photocatalysts with electro-spun fibers has been widely studied.However,those methods usually require multi-step preparation and complex operations.Considering this,a novel metallic Bi-decorated flexible multiphase Bi_(x)Ti_(y)O_(z)/TiO_(2) electrospun carbon nanofibers(Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs)with high photocatalytic efficiency,good mechanical property,good stability,easy separation,and recovery were synthesized via a one-step approach of pre-oxidation and carbonization treatment.The as-prepared Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs with multiphase Bi_(x)Ti_(y)O_(z),anatase TiO_(2),and metallic Bi particles embedded not only enhance the harvest of light but also pro-vide more separation paths for photogenerated carriers,which improve photocatalytic efficiency greatly.The Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs(S3)exhibited excellent photocatalytic performance and the degradation rate of 10 mg L^(-1) Rhodamine B(RhB)was up to 97%in only 30 min under simulated sunlight irradiation.Also,S3 exhibited stable activity during 5 cycles of experiments since the degradation rates remained at about 97%in 30 min.The mechanism of degradation of RhB by Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs in the photocat-alytic process was also proposed based on active species trapping experiments.The work in this paper shows that Bi/Bi_(x)Ti_(y)O_(z)-TiO_(2)/CNFs are easy to prepare and have high photocatalytic ability and stability,thereby offering a new strategy in catalyst immobilization and wastewater treatment. | Liangtao Yao Changpo Sun Hui Lin Guisheng Li Zichao Lian Ruixin Song Songlin Zhuang Dawei Zhang | 2023 | Journal of Materials Science & Technology2023，，19： | 0 |
| 4 | A novel numerical simulation method for predicting compressive properties of 3D multiaxial braided composites considering various defects显示文摘This paper reports a novel manufacturing process of preparing the Three-Dimensional Multiaxial Braided Composites(3DMBCs) and the effects of various defects generated in the manufacturing process on the compressive mechanical properties of 3DMBCs through the experimental and numerical methods. The five-step fabrication process of the 3D multiaxial braided preform was firstly introduced in detail. Then, the influences of various defects such as voids, waviness, and fiber breakage defects on the compressive properties of 3DMBCs were discussed. It is found that the fiber breakage defect and waviness defects were the two primary factors on the decrease of compressive properties of 3DMBCs. However, void defects in the resin and interface had little effect on the composites. When the fiber breakage defect content was 25% and the waviness was 7°, the composite compressive modulus decreased by 51%. The progressive damage process and failure mechanism of the composite under 90° compressive loading confirmed the validity of the numerical model by comparing with the experiments. | Ruixin LEI Hao DOU Yan SUN Tao LIU Wei FAN Chenyang SONG Shujuan WANG Yao LU Xue YANG Diansen LI | 2023 | Chinese Journal of Aeronautics2023，36，9： | 0 |
| 5 | Characterization and evaluation of a femtosecond laser-induced osseointegration and an anti-inflammatory structure generated on a titanium alloy显示文摘Cell–material interactions during early osseointegration of the bone–implant interface are critical and involve crosstalk between osteoblasts and osteoclasts.The surface properties of titanium implants also play a critical role in cell–material interactions.In this study,femtosecond laser treatment and sandblasting were used to alter the surface morphology,roughness and wettability of a titanium alloy.Osteoblasts and osteoclasts were then cultured on the resulting titanium alloy disks.Four disk groups were tested:a polished titanium alloy(pTi)control;a hydrophilic micro-dislocation titanium alloy(sandblasted Ti(STi));a hydrophobic nano-mastoid Ti alloy(femtosecond laser-treated Ti(FTi));and a hydrophilic hierarchical hybrid micro-/nanostructured Ti alloy[femtosecond laser-treated and sandblasted Ti(FSTi)].The titanium surface treated by the femtosecond laser and sandblasting showed higher biomineralization activity and lower cytotoxicity in simulated body fluid and lactate dehydrogenase assays.Compared to the control surface,the multifunctional titanium surface induced a better cellular response in terms of proliferation,differentiation,mineralization and collagen secretion.Further investigation of macrophage polarization revealed that increased anti-inflammatory factor secretion and decreased proinflammatory factor secretion occurred in the early response of macrophages.Based on the above results,the synergistic effect of the surface properties produced an excellent cellular response at the bone–implant interface,which was mainly reflected by the promotion of early ossteointegration andmacrophage polarization. | Yang Liu Zhongying Rui Wei Cheng Licheng Song Yunqiang Xu Ruixin Li Xizheng Zhang | 2021 | Regenerative Biomaterials2021，8，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员