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| 1 | Cocrystallization of N-donor type compounds with 5-sulfosalicylic acid:The effect of hydrogen-bonding supramolecular architectures显示文摘Benzotriazole,N,N'-dimethylpiperazine and N-methylpiperazine were applied to crystallize with 5-sulfosalicylic acid(5-H2SSA),affording three new binary molecular cocrystals [(C6H6N3+).(C7H5O6S-)].H2O(1),[(C6H16N22+)1/2.(C7H5O6S-)].H2O(2) and [(C5H14N22+).(C7H5O6S-)2].3H2O(3) under general conditions.Proton-transferring occurs from acid to nitrogen of N-donor compounds in all compounds 1,2 and 3.Analysis of the hydrogen-bonding synthons and their effects on crystal packing were also presented in the context of crystal engineering and host-guest chemistry.In compound 1,1-D infinite chains are extended to a 2-D layered architecture via strong O-H...O hydrogen bonds and then to a 3-D network by N-H...O interactions.Compound 2 and 3 both have the 1-D chain which is formed by O-H...O bonds and weak C-H...O hydrogen bonds.A common intramolecular S(6) [synthon I] ring is formed by the hydroxyl with the carboxyl group in all three compounds. | WANG Lei XU LingYan XUE RuiFeng LU XiFeng CHEN RuiXin TAO XuTang | 2012 | Science China Chemistry2012，55，1： | 8 |
| 2 | MicroRNA expression profile of gastric cancer stem cells in the MKN-45 cancer cell line显示文摘MicroRNAs (miRNAs ) 玩在目标送信人 RNA 的 post-transcriptional 基因 silencing 的重要角色,它几乎涉及所有生物过程。以前,我们证明了从 MKN-45 癌症房间的形成身体的房间衬里的球状体拥有了胃的癌症干细胞(CSC ) 性质。在这研究,我们试图决定胃的 CSC 的 miRNA 侧面并且在胃的 CSC 探索 miRNAs 的角色。人的 miRNA microarrays,它包含为 1887 人的 miRNAs 特定的探针被用来决定胃的 CSC 的表示侧面。有一个超过 2 褶层变化的 182 miRNAs 的一个总数被识别是在球状体之间表示的差别形成身体的房间和父母房间。这些 miRNAs, 9 miRNAs 在球状体是过去表示的形成身体的房间当另外的 173 miRNAs 都是下面表示的时,显示在人的胃的 CSC 的大多数 miRNAs 的角色可以是肿瘤 suppressors。microarray 分析的结果被量的即时聚合酶链反应验证,并且坚固性率是 70%(7 从 10 ) 。为验证 miRNAs 的目标基因被使用三个联机软件程序预言,人权保护, PicTar,和 TargetScan。大多数 miRNAs 的潜在的目标与在癌症的肌动朊细胞骨架,焦点的粘附,细胞外的 matrixreceptor 相互作用,和小径的规定相关。特别,几基因与干细胞基因的一些枢轴的发信号小径被联系。评估胃的 CSC 的典型 miRNAs 可以是为学习胃的癌症并且开发治疗学的策略的一个新方法,它在胃的癌症在根除瞄准了 CSC 的 subpopulation。 | Jianming Liu Lilin Ma Zhiwei Wang Lei Wang Chun Liu Ruixin Chen Jianguo Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 6 |
| 3 | Impact of oceans on climate change in drylands显示文摘Drylands account for approximately 41% of the global total land area. Significant warming and rare precipitation in drylands result in a fragile ecology and deterioration of the living environment, making it more sensitive to global climate change. As an important regulator of the Earth's climate system, the oceans play a vital role in the process of climate change in drylands. In modern climate change in particular, the impact of marine activities on climate change in drylands cannot be neglected. This paper reviews the characteristics of climate change in drylands over the past 100 years, and summarizes the researches conducted on the impact of marine activities on these changes. The review focuses on the impact of the Pacific Decadal Oscillation(PDO), Atlantic Multidecadal Oscillation(AMO), El Ni?o and La Ni?a on climate change in drylands, and introduces the mechanisms by which different oceanic oscillation factors synergistically affect climate change in drylands.Studies have shown that global drylands have experienced a significant intensification in warming in the past 100 years, which shows obvious characteristics of interdecadal dry/wet variations. The characteristics of these changes are closely related to the oscillatory factors of the oceanic interdecadal scale. Different phase combinations of oceanic oscillation factors significantly change the land-sea thermal contrast, which in turn affects the westerly jet, planetary wave and blocking frequency, resulting in changes in the temperature and dry/wet characteristics of drylands. With the intensification of climate change in drylands, the impact of marine activities on these regions will reveal new characteristics in the future, which will increase the uncertainty of future climate change in drylands and intensify the impact of these drylands on global climate. | Xiaodan GUAN Jieru MA Jianping HUANG Ruixin HUANG Lei ZHANG Zhuguo MA | 2019 | Science China Earth Sciences2019，62，6： | 5 |
| 4 | A Novel Strategy to Fabricate Core-Sheath Structure Piezoelectric Yarns for Wearable Energy Harvesters显示文摘Wearable and portable electronic devices based on textile structure have been widely used owing to their wearability and comfortableness.However,yarn fineness and the comfort of the fabric cannot satisfy the requirements of smart wearable devices.This work presents a novel strategy to prepare highly integrated PVDF/conductive nylon core-sheath structure piezoelectric yarns for wearable which is fabricated by combining electrospinning strategy with 2D braiding technology.The fineness of single yarns as well as strength are both improved significantly compared to previous works.The piezoelectric outputs of the yarn are still stable after 800 s fatigue test at a frequency of 4 Hz,and the cycle stability can maintain more than 3200 cycles.Furthermore,the piezoelectric yarns are further woven into piezoelectric plain fabric.According to the electrical performance,the length of the piezoelectric yarn and the thickness of the piezoelectric layer would both affect the output electrical performance.The yarn of the 10 cm in length and 600μm in fineness can produce an output voltage of 120 mV.Meanwhile,Both the piezoelectric yarn and the fabric could generate piezoelectric output signals through human movement,such as bending,walking.Therefore,the electrical and mechanical performance of the piezoelectric yarns prepared in our work could be improved significantly,and the comfortableness and durability performance of the piezoelectric fabric can satisfy most wearing requirements,which would provide some help in the field of piezoelectric wearable devices based on yarns and fabrics. | Lili Xue Wei Fan Yang Yu Kai Dong Chengkun Liu Yanli Sun Cong Zhang Weichun Chen Ruixin Lei Kai Rong Qi Wang | 2021 | Advanced Fiber Materials2021，3，4： | 3 |
| 5 | Multi-component hydrogen-bonding salts formed between imidazole and aromatic acids:Synthons cooperation and crystal structures显示文摘Imidazole base was crystallized with different aromatic carboxylic acids 2,4-dihydroxybenzoic acid, 5-chlorosalicylic acid, and 1,8-naphthalic acid, affording three new binary molecular organic salts of [(C 3 H 5 N 2 + )·(C 7 H 5 O 4 )] (1), [(C 3 H 5 N 2 + )·(C 7 H 4 O 3 Cl )] C 7 H 5 O 3 Cl (2), and [(C 3 H 5 N 2 + ) (C 12 H 7 O 4 )] (3). Proton transfer occurs from the COOH of carboxylic acid to nitrogen of imidazole in all complexes (1-3), leading to the hydrogen bond N-H…O in all structures. To our knowledge, the recognition pattern between the carboxylic acid group and imidazole (acid-imidazole synthon) is less well-studied so far. The cooperation among COOH, COO and imidazolium cation functional groups for the observed hydrogen bond synthons is examined in the three structures. Generally, the strong N-H…O and O-H…O hydrogen bonds define supramolecular architecture and connectivity within chains, while weaker C-H…O hydrogen bonds play the dominant role in controlling the interactions between layers in these novel organic salts. Thermal stability of these compounds has been investigated by thermogravimetric analysis (TGA) of mass loss. | WANG Lei ZHAO Lei LIU Meng CHEN RuiXin YANG Yu GU YuanXiang | 2012 | Science China Chemistry2012，55，10： | 2 |
| 6 | Chelating Properties of Salicylhydroxamic Acid-functionalized Polystyrene Resins and Its Application to Efficient Removal of Heavy Metal Ions from Aqueous Solutions显示文摘 | WANG Ruixin LEI Caiping WANG Hongjing SHI Xiaohui | 2015 | Chemical Research in Chinese Universities2015，31，3： | 2 |
| 7 | Hydrogen-bonding directed cocrystallization of flexible piperazine with hydroxybenzoic acid derivatives:Structural diversity and synthon prediction显示文摘Four hydroxybenzoic acid building blocks,m-hydroxybenzoic acid,2,4-dihydroxybenzoic acid,2,5-dihydroxyterephthalic acid,and 5-hydroxyisophthalic acid,have been synthesized as robust cocrystallizing agents and employed in reactions with piperazine,including [(C4H12N22+).(C7H5O3)2 ](1),[(C4H12N22+).(C 7H5O4)2 ](2),[(C4H12N22+).(C8H5O62)](3),and [(C4H12N22+)1/2.(C8H5O5)].2H2O(4).Hydrogen-bonded directed assemblies of four salts were validated by single-crystal X-ray diffraction analysis.In compounds 1-4,hydroxybenzoic acids are all deprotonated and piperazine molecules are all protonated to form piperazine dications and keep the chair conformation.Thermal stability of these compounds has been investigated. | WANG Lei XUE RuiFeng XU LingYan LU XiFeng CHEN RuiXin TAO XuTang | 2012 | Science China Chemistry2012，55，7： | 1 |
| 8 | Facet-dependent catalytic activity of CeO_(2) toward methanol synthesis from methane显示文摘The relationship between CeO_(2) morphology(nano rods,NR;nano cubes,NC;nano octahedra,NO) and methanol synthesis from methane at low reaction temperature was studied by using density functional theory(DFT) and experiments.CeO_(2)(110) displays the lowest energy barriers among CeO_(2)(100),CeO_(2)(111) and CeO_(2)(110) surfaces due to the strongest hybridization between O 2p orbital of OH and Ce4f orbital.As a result,CeO_(2)-NR has the highest methanol yield(1.52 μmol/gcat) compared with CeO_(2)-NC(0.60 μmol/gcat)and CeO_(2)-NO(0.66 μmol/gcat) at 453 K and 101325 Pa.These results show that methanol synthesis from methane at low reaction temperature on CeO_(2)is a morphology sensitive reaction. | Jiayao Feng Xiao Shi Ruixin Zhang Wenjing Wang Zhifeng Yan Zhihua Gao Wei Huang Lei Liu Zhijun Zuo | 2023 | Journal of Rare Earths2023，41，12： | 1 |
| 9 | Co-crystallization of glycine anhydride with the hydroxybenzoic acids: Controlled formation of dimers via synthons cooperation and structural characterization显示文摘The results of crystallographic analyses on 1:1 and 1:4 well-defined co-crystals formed between glycine anhydride and each of 4-hydroxybenzoic acid and 3,5-dihydroxybenzoic acid are described. Neutral molecules are connected via heteromeric O-H···O and N-H···O contacts leading to different packing arrangements of supramolecular chains. On the basis of the molecular structures of glycine anhydride and carboxylic acid guests, the hydrogen bonds are arranged to give centrosymmetric synthons V and VII which are noteworthy for their robustness. Hydrogen-bond interactions between glycine anhydride and aromatic acid provide sufficient driving force to direct molecular recognition and crystal packing. Utilization of the orientation of functional groups of the building blocks, the acidity, and weak interactions provides a route for the creation of novel supra- molecular architectures in the crystal lattice. Both two co-crystals contain the expected hydrogen-bonded motifs, and there has been no proton transfer from either of the two carboxylic acids to the aza compound moiety. This demonstrates that glycine anhydride is very capable of affecting the construction of binary co-crystals in a predictable and rationale manner. It is noted that synthons VⅢ and IX are fairly large, but the real challenge in crystal engineering is to find a big enough synthon that occurs often enough. Thermal stability of these compounds has been investigated by thermogravimetric analysis (TGA) of mass loss. | WANG Lei ZHAO Lei LIU WeiMing CHEN RuiXin GU YuanXiang YANG Yu | 2012 | Science China Chemistry2012，55，11： | 1 |
| 10 | Nonlinear optical material of a low-dimensional coordination polymer:Synthesis,structure,NLO and fluorescence properties显示文摘Employing unsymmetrical 2-mercapto-5-methyl-1,3,4-thiadiazole and 2,2′-bipyridine as mixed ligands, a new low-dimensional coordination polymer [Zn(MMTA) 2 (2,2′-bipy)] n (MMTA = 2-mercapto-5-methyl-1,3,4-thiadiazole, 2,2′-bipy = 2,2′-bipyridine), has been synthesized under solvothermal condition and characterized by single crystal X-ray diffraction. This compound crys- tallizes in the noncentrosymmetric space group Cc, with cell parameters: a = 8.291(4) , b = 15.483(9) , c = 15.620(6) , = 96.00(5)°, V = 1994.1(2) 3 , and Z = 4. The mixed ligands link the zinc center into a mononuclear unit, which is futher linked by weak C-H···N and C-H···S hydrogen bonds into a three-dimensional noncentrosymmetric framework. The compound exhibits intense photoluminescence and distinct NLO properties at room temperature. The intensity of the green light produced by the powder sample of the compound is about 3.2 times that produced by KDP powder. On the basis of the results of TG analysis, the structure is thermally stable up to ~260 °C. | WANG Lei ZHAO Lei LIU Meng CHEN RuiXin YANG Yu GU YuanXiang | 2012 | Science China Chemistry2012，55，10： | 1 |
| 11 | A novel numerical simulation method for predicting compressive properties of 3D multiaxial braided composites considering various defects显示文摘This paper reports a novel manufacturing process of preparing the Three-Dimensional Multiaxial Braided Composites(3DMBCs) and the effects of various defects generated in the manufacturing process on the compressive mechanical properties of 3DMBCs through the experimental and numerical methods. The five-step fabrication process of the 3D multiaxial braided preform was firstly introduced in detail. Then, the influences of various defects such as voids, waviness, and fiber breakage defects on the compressive properties of 3DMBCs were discussed. It is found that the fiber breakage defect and waviness defects were the two primary factors on the decrease of compressive properties of 3DMBCs. However, void defects in the resin and interface had little effect on the composites. When the fiber breakage defect content was 25% and the waviness was 7°, the composite compressive modulus decreased by 51%. The progressive damage process and failure mechanism of the composite under 90° compressive loading confirmed the validity of the numerical model by comparing with the experiments. | Ruixin LEI Hao DOU Yan SUN Tao LIU Wei FAN Chenyang SONG Shujuan WANG Yao LU Xue YANG Diansen LI | 2023 | Chinese Journal of Aeronautics2023，36，9： | 0 |
| 12 | Immobilization of Transition-metal Hydroxamates on Polystyrene Resins: Effective Biomimetic Heterogeneous Catalysts for Aerobic Oxidation of Ethylbenzene显示文摘 | WANG Ruixin WANG Hongjing WANG Xiaogang LEI Caiping SHI Xiaohui | 2015 | Chemical Research in Chinese Universities2015，31，5： | 0 |
| 13 | MUTUAL ARTIFICIAL BEE COLONY ALGORITHM FOR MOLECULAR DOCKING显示文摘 | RUIXIN MA XIUJUAN XU LEI ZHAO REN CAO QIANG FANG | 2013 | International Journal of Biomathematics2013，6，6： | 0 |
| 14 | Clinical utilization of olaparib,a PARP inhibitor,in BRCA1-mutant metastatic acral melanoma显示文摘Acral melanoma(AM)is a rare subtype of cutaneous melanoma linked to poor prognosis,largely due to a lacking of effective targeted therapeutic strategies.Whole-genome sequencing(WGS)data revealed that AM showed a different mutation landscape from cutaneous melanoma.1 BRCA1 and BRCA2 mutations appear in about 3%–16%of AMs.2,3 Pharmacologic inhibition of the DNA repair enzyme PARP has been approved by the FDA as monotherapy in patients with deleterious germline BRCA1/2 mutated advanced ovarian cancer,and the usage has been expanded to metastatic breast cancer,pancreatic cancer,and prostate cancer with homologous recombination repair(HRR)gene defects.4 However,whether AM with BRCA mutations is also sensitive to PARP inhibition is unknown.We identified a stageⅣAM patient with a germline BRCA1 frameshift mutation(BRAC1 G1384Nfs∗7)who was resistant to anti-PD1 therapy.Both patient-derived xenograft and cells(PDX/PDC)models from the same AM patient were established.PARP inhibitor olaparib significantly decreased cell proliferation and slowed tumor growth by increasing DNA double-strand breakage in AM cancer cells.Administration of olaparib to the patient achieved stable disease for 3 months.This study provides preclinical and clinical evidence that PARP inhibitors can slow tumor growth in BRCA1-mutant advanced acral melanoma. | Ruixin Jiang Xianbin Liang Ye Tao Ronghui Xia Ming Lei Bin Jiang Robert LJudson-Torres Yanjie Zhang Weizhen Zhang Hanlin Zeng | 2023 | Genes & Diseases2023，10，5： | 0 |
| 15 | Synthesis and characterization of a new open-framework zinc phosphite (4,4-(C_5H_4N)_2(CH_2)_3)·[Zn_3(HPO_3)_4]显示文摘Employing 4,4-trimethylenedipyridine as a template,a new two-dimensional zinc phosphite (4,4-(C5H4N)2(CH2)3)· [Zn3(HPO3)4 ] has been prepared at room temperature and characterized by single-crystal X-ray diffraction,FTIR,elemental analysis,powder X-ray diffraction,and thermogravimetric analysis.The compound crystallizes in the monoclinic space group P2 1 /c,with cell parameters,a=9.3309(19),b=14.798(3),c=33.637(7),β=91.11(3),V=4643.8(16) nm 3 and Z=4.The connectivity of the ZnO4 tetrahedra and HPO 3 pseudo pyramids results in infinite corner-sharing 4-membered ring chains as second building units which are further linked by Zn O P bonds to form a 2-D layer that with interesting 8-membered ring channels along the [100] direction.The diprotonated 4,4-trimethylenedipyridine molecules sit in the middle of the layers along the [100] direction and interact with the framework via hydrogen bonds. | WANG Lei XUE RuiFeng CHEN RuiXin LU XiFeng LI GuangHua TAO XuTang | 2012 | Science China Chemistry2012，55，3： | 0 |
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