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| 1 | Comparsion analysis of data mining models applied to clinical research in Traditional Chinese Medicine显示文摘OBJECTIVE: To help researchers selecting appropriate data mining models to provide better evidence for the clinical practice of Traditional Chinese Medicine(TCM) diagnosis and therapy.METHODS: Clinical issues based on data mining models were comprehensively summarized from four significant elements of the clinical studies:symptoms, symptom patterns, herbs, and efficacy.Existing problems were further generalized to determine the relevant factors of the performance of data mining models, e.g. data type, samples, parameters, variable labels. Combining these relevant factors, the TCM clinical data features were compared with regards to statistical characters and informatics properties. Data models were compared simultaneously from the view of applied conditions and suitable scopes.RESULTS: The main application problems were the inconsistent data type and the small samples for the used data mining models, which caused the inappropriate results, even the mistake results. These features, i.e. advantages, disadvantages, satisfied data types, tasks of data mining, and the TCM issues, were summarized and compared.CONCLUSION: By aiming at the special features of different data mining models, the clinical doctors could select the suitable data mining models to resolve the TCM problem. | Yufeng Zhao Qi Xie Liyun He Baoyan Liu Kun Li Xiang Zhang Wenjing Bai Lin Luo Xianghong Jing Ruili Huo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 14 |
| 2 | Characterization of aroma compounds of Pu-erh ripen tea using solvent assisted flavor evaporation coupled with gas chromatography-mass spectrometry and gas chromatography-olfactometry显示文摘Pu-erh ripen tea becomes popular worldwide owing to its unique taste and aroma.In the present study,volatile compounds from Pu-erh ripen tea were extracted using a solvent assisted flavor evaporation(SAFE)and analyzed with a gas chromatography-mass spectrometry(GC-MS)and a gas chromatography olfactometry(GC-O).Results demonstrated that 58 major volatile compounds and 24 aroma active substances of Pu-erh ripen tea were identified by GC-MS and GC-O analysis.Among volatile compounds identified,methoxyphenyl compounds were considered as the dominate compounds in the aroma of Pu-erh ripen tea.Further investigation showed that 6 methoxybenzenes were responsible for the aging aroma in Pu-erh ripen tea;α-ionone,3,4-dimethoxytoluene,1,3-dimethoxybenzene,etc.were responsible for the wood-like aroma.Linalool,α-terpineol,α-ionone,β-ionone,and benzeneacetaldehyde were responsible for the floral odor.Compared the odor detection threshold(ODT)among the 8 methoxyphenyl compounds in water,1,2,3-trimethoxybenzene showed the highest ODT,followed by 3,4-dimethoxyphenol.1,3-dimethoxybenzene(105μg/L)and 1,2,3-trimethoxy-5-methylbenzene(100μg/L)were present at relatively low odor threshold values.The result indicated that methoxyphenyl compounds play a vital role in the unique flavor of Pu-erh ripen tea. | Bei Wang Qing Meng Lin Xiao Ruili Li Chunhai Peng Xueli Liao Jingna Yan Honglin Liu Guanhua Xie Chi-Tang Ho Huarong Tong | 2022 | Food Science and Human Wellness2022，11，3： | 6 |
| 3 | HMW glutenin subunits in multiploid Aegilops species: composition analysis and molecular cloning of coding sequences显示文摘The Aegilops genus contains species closely related to wheat. In common with wheat, Aegilops species accumulate high molecular weight (HMW) glutenin subunits in their endospermic tissue. In this study, we investigated the composition of HMW glutenin subunits in four multiploid Aegilops species using SDS-PAGE analysis. Furthermore, by working with Ae. ventricosa, we established an efficient ge-nomic PCR condition for simultaneous amplification of DNA sequences coding for either x- or y-type HMW glutenin sub-units from polyploid Aegilops species. Using the genomic PCR condition, we amplified and subsequently cloned two DNA fragments that may code for HMW glutenin subunits in Ae. ventricosa. Based on an analysis of the deduced amino acid sequences, we concluded that the two cloned sequences encode one x- and one y-type of HMW glutenin subunit, respectively. | Ruili Xie Yongfang Wan Yan Zhang Daowen Wang | 2001 | Chinese Science Bulletin2001，46，4： | 6 |
| 4 | ATP11B deficiency leads to impairment of hippocampal synaptic plasticity显示文摘Synaptic plasticity is known to regulate and support signal transduction between neurons, while synaptic dysfunction contributes to multiple neurological and other brain disorders;however, the specific mechanism underlying this process remains unclear. In the present study, abnormal neural and dendritic morphology was observed in the hippocampus following knockout of Atpllb both in vitro and in vivo. Moreover, ATP11B modified synaptic ultrastructure and promoted spine remodeling via the asymmetrical distribution of phosphatidylserine and enhancement of glutamate release, glutamate receptor expression, and intracellular Ca^2+ concentration. Fuithermoe experimental results also indicate that ATP11B regulated synaptic plasticity in hippocampal neurons through the MAPK14 signaling pathway. In conclusion, our data shed light on the possible mechanisms underlying the regulation of synaptic plasticity and lay the foundation for the exploration of proteins involved in signal transduction during this process. | Jiao Wang Weihao Li Fangfang Zhou Ruili Feng Fushuai Wang Shibo Zhang Jie Li Qian Li Yajiang Wang Jiang Xie Tieqiao Wen | 2019 | Journal of Molecular Cell Biology2019，11，8： | 2 |
| 5 | Mirror-assisted multi-view high-speed digital image correlation for dual-surface dynamic deformation measurement显示文摘Based on the recently proposed mirror-assisted multi-view digital image correlation(MV-DIC),we establish a cost-effective and easy-to-implement mirror-assisted multi-view high-speed digital image correlation(MVHS-DIC)method and explore its applications for dual-surface full-field dynamic deformation measurement.In contrast to the general requirement of four expensive high-speed cameras for dual-surface dynamic deformation field measurement,the established mirror-assisted MVHS-DIC halves the cost by involving only two synchronized high-speed cameras and two planar mirrors.The two synchronized high-speed cameras can dynamically measure the front and rear surfaces of a sheet sample simultaneously through the reflection of the two mirrors.The results on the two surfaces are then transformed into the same coordinate system,leading to the required dual-surface 3D dynamical deformation fields.The effectiveness and accuracy of the established system are validated through modal tests of a cantilever aluminum sheet.The vibration measurement of a drum and dual-surface transient deformation measurement of a smartphone in the drop-collision process further prove its practicability.Benefiting from the attractive advantages of multi-view dynamic deformation measurement in a cost-efficient way,the established mirror-assisted MVHS-DIC is expected to encourage more comprehensive dynamic mechanical behavior characterization of regular-sized materials and structures in vibration and impact engineering fields. | XIE RuiLi CHEN Bin PAN Bing | 2023 | Science China(Technological Sciences)2023，66，3： | 1 |
| 6 | The Application of UAV-Based Hyperspectral Imaging to Estimate Crop Traits in Maize Inbred Lines显示文摘Crop traits such as aboveground biomass(AGB),total leaf area(TLA),leaf chlorophyll content(LCC),and thousand kernel weight(TWK)are important indices in maize breeding.How to extract multiple crop traits at the same time is helpful to improve the efficiency of breeding.Compared with digital and multispectral images,the advantages of high spatial and spectral resolution of hyperspectral images derived from unmanned aerial vehicle(UAV)are expected to accurately estimate the similar traits among breeding materials.This study is aimed at exploring the feasibility of estimating AGB,TLA,SPAD value,and TWK using UAV hyperspectral images and at determining the optimal models for facilitating the process of selecting advanced varieties.The successive projection algorithm(SPA)and competitive adaptive reweighted sampling(CARS)were used to screen sensitive bands for the maize traits.Partial least squares(PLS)and random forest(RF)algorithms were used to estimate the maize traits.The results can be summarized as follows:The sensitive bands for various traits were mainly concentrated in the near-red and red-edge regions.The sensitive bands screened by CARS were more abundant than those screened by SPA.For AGB,TLA,and SPAD value,the optimal combination was the CARS-PLS method.Regarding the TWK,the optimal combination was the CARS-RF method.Compared with the model built by RF,the model built by PLS was more stable.This study provides guiding significance and practical value for main trait estimation of maize inbred lines by UAV hyperspectral images at the plot level. | Meiyan Shu Mengyuan Shen Jinyu Zuo Pengfei Yin Min Wang Ziwen Xie Jihua Tang Ruili Wang Baoguo Li Xiaohong Yang Yuntao Ma | 2021 | Plant Phenomics2021，3，1： | 1 |
| 7 | Immunomodulatory hybrid bio-nanovesicle for self-promoted photodynamic therapy显示文摘Thylakoid(Tk)membranes are of unique superiority in photodynamic therapy(PDT)because they not only carry abundant chlorophylls containing photosensitizer porphyrin but also can produce O_(2).However,the current therapeutic performance of Tk is dramatically limited because of their poor tumor targeting and inefficient O_(2) production.Here,we report an immunomodulatory bio-nanovesicle of Tk membranes fused with M1 macrophage-derived extracellular vesicles(M1 EV)for efficient PDT of tumors.The hybrid nanovesicle Tk@M1 was prepared by squeezing the Tk membranes of spinach with M1 EV.The systemic study confirmed that Tk@M1 can not only actively accumulate in tumors but also effectively regulate the inactive immune microenvironment of tumors.Such activated'hot'tumors significantly enhance the PDT efficacy of Tk@M1 attributed to the increased O_(2) from catalase catalyzed decomposition of augmented H_(2)O_(2),providing a novel idea about constructing natural systems for effective tumor treatment. | Houli Liu Yao Lei Weidong Nie Helin Zhao Yuzhu Wu Liping Zuo Guanghao Wu Ruili Yang Hai-Yan Xie | 2022 | Nano Research2022，15，5： | 1 |
| 8 | A neural networks based model for rate-dependent hysteresis for piezoceramic actuators显示文摘 | Ruili Dong Yonghong Tan Hui Chen Yangqiu Xie | 2008 | Sensors & Actuators: A Physical2008，，2： | 1 |
| 9 | Nonlinear Model- ing and Decoupling Control of XY Micropositioning Stages With Piezoelectric Actuators 显示文摘 | Yangqiu Xie Yonghong Tan Ruili Dong | 2013 | Mechatronics IEEE/ ASME Transactions2013，18，3： | 1 |
| 10 | A Dynamic Hysteresis Model of Piezoelectric Ceramic Actuators显示文摘A modified Prandtl-Ishlinskii(PI)model with rate-dependent thresholds for describing the hysteresis characteristics of piezoelectric actuators is proposed.Based on the classical PI model,a novel threshold depending on the input rate is constructed.With the novel rate-dependent threshold,the play operator has the capability to track the frequency variation of the input signal.Hence,the proposed modified PI model can be used to depict the rate-dependent hysteresis of piezoelectric actuators.Experimental results are presented to illustrate the model validation results of the proposed modeling. | DONG Ruili TAN Yonghong XIE Yingjie LI Xiaoli | 2023 | Chinese Journal of Electronics2023，32，6： | 0 |
| 11 | Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis显示文摘Atherosclerosis is the most common cause of cardiovascular diseases that contribute to the major morbidity worldwide,but still lacking of effective treatment strategy.Here,a hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis by fusing M2 macrophages with thylakoid(TK)membranes.After systemic administration,the obtained TK-M2 actively accumulates in the early atherosclerotic plaques,wherein M2 macrophages relieve the cholesterol accumulation and the inflammation in the foam cells.Meanwhile,the TK membranes decorated on the M2 macrophages exhibit both type I and type II sonodynamic effects under ultrasound(US)activation,inducing the direct apoptosis of foam cells.The cooperation of M2 and TK leads to significant outcome in eliminating atherosclerotic plaques without obvious side-effects,providing a new avenue for atherosclerosis treatment. | Guanghao Wu Changwen Mu Qianru Zhao Yao Lei Ran Cheng Weidong Nie Jiamin Qu Yuping Dong Ruili Yang Haiyan Xie | 2024 | Nano Research2024，17，4： | 0 |
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