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| 1 | Prediction of major adverse cardiac events is the first critical task in the management of immune checkpoint inhibitor-associated myocarditis显示文摘Dear Editor,The application of immune checkpoint inhibitors(ICIs),anti-tumor immunotherapy unleashing the host immune system to eradicate tumor cells,has revolutionized the treatment of various advanced cancers and showed remarkable anti-tumor effects[1].However,emphasis must be placed on fatal immune-related adverse events(irAEs),especially some fulminant irAEs like ICI-related cardiovascular AEs[2,3].However,due to the low rate of cardiovascular AEs,little is known about the effective methods for evaluating the risk of catastrophic cardiac events in ICI-associated myocarditis and its management[4,5]. | Yan Xu Yanjun Song Xiaoyan Liu Yuequan Shi Yingxian Liu Hao Qian Xiaoxing Gao Minjiang Chen Ruili Pan Jing Zhao Wei Zhong Wei Wu Mengzhao Wang | 2022 | Cancer Communications2022，42，9： | 3 |
| 2 | Design Technologies for Silicon-Based High-Efficiency RF Power Amplifiers:A Brief Overview显示文摘This paper presents a brief overview of several promising design technologies for high efficiency silicon-based radio frequency(RF) power amplifiers(PAs) as well as the use of these technologies in mobile broadband wireless communications.Four important aspects of PA design are addressed in this paper.First,we look at class-E PA design equations and provide an example of a class-E PA that achieves efficiency of 65-70% at 2.4 GHz.Then,we discuss state-of-the-art envelope tracking(ET) design for monolithic wideband RF mobile transmitter applications.A brief overview of Doherty PA design for the next-generation wireless handset applications is then given.Towards the end of the paper,we discuss an inherently broadband and highly efficient class-J PA design targeting future multi-band multi-standard wireless communication protocols. | Ruili Wu Jerry Lopez Yan Li Donald Y.C.Lie | 2011 | ZTE Communications2011，9，3： | 1 |
| 3 | Immunomodulatory hybrid bio-nanovesicle for self-promoted photodynamic therapy显示文摘Thylakoid(Tk)membranes are of unique superiority in photodynamic therapy(PDT)because they not only carry abundant chlorophylls containing photosensitizer porphyrin but also can produce O_(2).However,the current therapeutic performance of Tk is dramatically limited because of their poor tumor targeting and inefficient O_(2) production.Here,we report an immunomodulatory bio-nanovesicle of Tk membranes fused with M1 macrophage-derived extracellular vesicles(M1 EV)for efficient PDT of tumors.The hybrid nanovesicle Tk@M1 was prepared by squeezing the Tk membranes of spinach with M1 EV.The systemic study confirmed that Tk@M1 can not only actively accumulate in tumors but also effectively regulate the inactive immune microenvironment of tumors.Such activated'hot'tumors significantly enhance the PDT efficacy of Tk@M1 attributed to the increased O_(2) from catalase catalyzed decomposition of augmented H_(2)O_(2),providing a novel idea about constructing natural systems for effective tumor treatment. | Houli Liu Yao Lei Weidong Nie Helin Zhao Yuzhu Wu Liping Zuo Guanghao Wu Ruili Yang Hai-Yan Xie | 2022 | Nano Research2022，15，5： | 1 |
| 4 | Construction, Expression and Characteriza-tion of a Single Chain Variable Fragment An-tibody Against Human Myostatin显示文摘 | Wu Bingbing Yuan Taoyan Qi Ruili | 2014 | Proteinand Peptide Letters2014，21，1： | 1 |
| 5 | Effect of im- munization with a recombinant cholera toxin B subunit/soma- tostatin fusion protein on immune response and growth hor- mone levels in mice 显示文摘 | Wu Bingbing Yuan Taoyan Qi Ruili | 2012 | Biotechnology Letters2012，34，12： | 1 |
| 6 | Nitrogen- doped ordered mesoporous graphitic arrays with high electro- catalytic activity for oxygen reduction 显示文摘 | LIU Ruili WU Dongqing FENG Xinliang | 2010 | Angewandte Che- mic2010，122，14： | 1 |
| 7 | An aqueous route to multicolor photoluminescent carbon dots using silica spheres as carriers 显示文摘 | Liu Ruili Wu Dongqing Liu Shuhua | 2009 | Angew Chem Int Ed2009，48，25： | 1 |
| 8 | Development of novel mordenite-filled chitosan-poly (acrylic acid) polyelectrolyte complex membranes for pervaporation dehydration of ethylene glycol aqueous solution显示文摘 | Hu Changlai Guo Ruili Li Ben Ma Xiaocong Wu Hong Jiang Zhongyi | 2007 | Journal of Membrane Science2007，293，12： | 1 |
| 9 | Air pollution health burden embodied in China's supply chains显示文摘Product trade plays an increasing role in relocating production and the associated air pollution impact among sectors and regions.While a comprehensive depiction of atmospheric pollution redistribution through trade chains is missing,which may hinder targeted clean air cooperation among sectors and regions.Here,we combined five state-of-the-art models from physics,economy,and epidemiology to track the anthropogenic fine particle matters(PM_(2.5))related premature mortality along the supply chains within China in 2017.Our results highlight the key sectors that affect PM_(2.5)-related mortality from both production and consumption perspectives.The consumption-based effects from food,light industry,equipment,construction,and services sectors,caused 2e22 times higher deaths than those from a production perspective and totally contributed 63%of the national total.From a cross-boundary perspective,25.7%of China's PM_(2.5)-related deaths were caused by interprovincial trade,with the largest transfer occurring from the central and northern regions to well-developed east coast provinces.Capital investment dominated the cross-boundary effect(56%of the total)by involving substantial equipment and construction products,which greatly rely on product exports from regions with specific resources.This supply chain-based analysis provides a comprehensive quantification and may inform more effective joint-control efforts among associated regions and sectors from a health risk perspective. | Hongyan Zhao Ruili Wu Yang Liu Jing Cheng Guannan Geng Yixuan Zheng Hezhong Tian Kebin He Qiang Zhang | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 10 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 11 | Research Progress of HPV L1 Capsid Protein in Prediction of Cervical Lesions显示文摘Cervical cancer is one of the most common malignant gynecological tumors and has the second highest incidence of all malignancies in females.Chronic and persistent infection with High Risk Human Papillomavirus(HR-HPV)is the main cause of cervical cancer.There is a distinct lack of methodology by which to determine whether cervical epithelial dysplasia is cancerous following HPV infection.HPV L1 capsid protein is a major structural protein of human papillomavirus(HPV),and it is the main target of the local cellular immune response aiming to combat human papillomavirus after HPV infection within cervical cells.Greater understanding of HPV L1 capsid protein and its association with cervical cytology,histopathology,patient age and human papillomavirus viral load has the potential to contribute toward improved the diagnosis and management of cervical cancer,providing useful information for gynecological clinicians in the hope of improving patient treatment and quality of life.This article reviews the predictive utility of HPV L1 capsid protein for cervical lesions. | Jing Cheng Lin Xu Beibei Liu Biao Wang Xicui Long Zhihong Li Ruiting Wu Ruili Chen | 2020 | Proceedings of Anticancer Research2020，4，6： | 0 |
| 12 | Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis显示文摘Atherosclerosis is the most common cause of cardiovascular diseases that contribute to the major morbidity worldwide,but still lacking of effective treatment strategy.Here,a hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis by fusing M2 macrophages with thylakoid(TK)membranes.After systemic administration,the obtained TK-M2 actively accumulates in the early atherosclerotic plaques,wherein M2 macrophages relieve the cholesterol accumulation and the inflammation in the foam cells.Meanwhile,the TK membranes decorated on the M2 macrophages exhibit both type I and type II sonodynamic effects under ultrasound(US)activation,inducing the direct apoptosis of foam cells.The cooperation of M2 and TK leads to significant outcome in eliminating atherosclerotic plaques without obvious side-effects,providing a new avenue for atherosclerosis treatment. | Guanghao Wu Changwen Mu Qianru Zhao Yao Lei Ran Cheng Weidong Nie Jiamin Qu Yuping Dong Ruili Yang Haiyan Xie | 2024 | Nano Research2024，17，4： | 0 |
| 13 | Characteristics of the multiple replicon plasmid IncX1-X1 in multidrug-resistant Escherichia coli from Malayan pangolin(Manis javanica)显示文摘Potential zoonotic pathogens may be transmitted from wildlife to humans through the illegal wild meat trade,which has become a pressing issue.However,research on the antimicrobial resistance genes(ARGs)of Malayan pangolin(Manis javanica)intestinal bacteria is limited.Here,multidrug-resistant Escherichia coli M172-1(ST354)isolated from Malayan pangolin feces in 2019 was found to be resistant to 13 antibiotics.BGWAS analysis revealed 4 plas-mids,namely,pM172-1.1,pM172-1.2,pM172-1.3,and pM172-1.4,in the isolate.The pM172-1.2,pM172-1.3,and pM172-1.4 plasmids carried ARGs,namely,IncHI2-HI2A,IncX1-X1,and IncX1,respectively.pM172-1.3 and pM172-1.4 contained intact IntI1 integrons(Is26/IntI1/arr2/cmlA5/blaOXA-10/ant(3′′)-IIA/dfrA14/Is26).No-tably,pM172-1.3 resulted from the fusion of 2 pM172-1.4 copies and carried many more ARGs.In addition to pM172-1.3 from the same host,other drug-resistant bacteria(E.coli M159-1(ST48),E.coli S171-1(ST206),and Klebsiella pneumoniae S174-1(ST2354))in the same Malayan pangolin fecal samples also carried 3 plasmids with 100%gene coverage of pM172-1.4 and 99.98%identity.Therefore,ARGs in IncX1 might spread in the intestinalflora of Malayan pangolin and between species via the illegal food chain,posing a potential threat to public health and safety. | Fang JI Shelan LIU Xue WANG Jianan ZHAO Jiayue ZHU Jianchun YANG Chenglin ZHANG Zhongxin JIA Ruili ZHAO Guocheng HU Jing WANG Jianhua QIN Gang LI Bin WU Chengmin WANG | 2023 | Integrative Zoology2023，18，2： | 0 |
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