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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Targeting the Raf - MEK - ERK mitogen- activated protein kinase cascade for the treat- ment of cancer 显示文摘 | Roberts PJ Der CJ | 2007 | Oncogene2007，26，22： | 1 |
| 3 | Effect of the tyrosine kinase inhabitor STI571 in a patient with a matastatic gastrointestinal stromal tumor显示文摘 | Joensuu H Roberts PJ Sarlomo-Rikala M | 2001 | N Eng J Med2001，344，14： | 1 |
| 4 | Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor显示文摘 | Joensuu H Roberts PJ Sarlomo-Rikala M | 2001 | N Engl J Med2001，344，14： | 1 |
| 5 | Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease 显示文摘 | Roberts PJ Morgan K Miller R | 2001 | Gut2001，48，4： | 1 |
| 6 | Effect of the ty- rosine kinase inhabitor STI571 in a patient with a matastatic, gas- trointestinal stromal tumor 显示文摘 | Joensuu H Roberts PJ Sarlomo-Rikala M | 2001 | N Eng J Med2001，344，14： | 1 |
| 7 | Comparison of a new tumour marker CA 242 with CA 19-9,CA 50 and carcinoembryonic antigen(CEA) in digestive tract diseases显示文摘 | Kuusela P Haglund C Roberts PJ | 1991 | Br J Cancer1991，63，4： | 1 |
| 8 | Spontaneous cholesterol embolization complicated by pulmonary fat embolism显示文摘 | Jardine DL Davis PJ Robert A | 2001 | Intern Med J2001，31，5： | 1 |
| 9 | Prognostic significance of matrix metalloproeinases-1,-2,-7and-13 and tissue inhibitors of metalloproteinases-1,-2,-3and -4 in colorectal cancer显示文摘 | Hilska M Roberts PJ Collan YU | 2007 | Int J Cancer2007，121，4： | 1 |
| 10 | CA242, a new tumor marker for pancreatic cancer a comparison with CA199, CA50 and CEA显示文摘 | Huglund C Lundin J Roberts PJ et cd | 1994 | Br J Cancer1994，70，4： | 1 |
| 11 | Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease 显示文摘 | Roberts PJ Eisenberg B | 2002 | European J Cancer2002，385，： | 1 |
| 12 | Serum erythropoietin levels during infauey: association with erythropoiesis 显示文摘 | Kling PJ Schmidt RL roberts RA | 1996 | J Pediatr1996，128，： | 1 |
| 13 | Demonstration and biochemical characterization of rat brain NADPH-dependant diaphorase 显示文摘 | Kemp MC Roberts PJ | 1988 | Neurochemistry1988，50，4： | 1 |
| 14 | Are the cogni- tive effects of atypital antipsychotics influenced by their af- finity to 5HT2Atreceptors? 显示文摘 | Tyson PJ Roberts KH Mortimer AM | 2004 | Int J Neurosei2004，114，6： | 1 |
| 15 | Postoperative nausea and Vomiting are strongly influenced by postoperative Opioid use in a dose-related manner显示文摘 | Roberts GW Bekker TB Carlsen HH Moffatt CH Slattery PJ McClure AF | | 0，，05： | 1 |
| 16 | Comparison of a new tumour mark er CA242 with CA19-9, CA50 and carcinoembryonic antigen (CEA) in digestive tract diseases 显示文摘 | Kuusels Haglund C Roberts PJ | 1991 | Br J Cancer1991，63，4： | 1 |
| 17 | Clinical presentation of gastrointestinal stromal tumors and treatment of operable disease显示文摘 | Roberts PJ Elsenberg B | 2002 | Eur J Cancer2002，38，5： | 1 |
| 18 | Operative treatment of acetabular fractures in the Medicare population显示文摘 | Hayes PJ Carroll CM Roberts CS | 2013 | Orthopedics2013，36，8： | 1 |
| 19 | STI571 inactivation of the gastrointestinal stromal tumor c-kit oncoprotein:biological and clinical implications显示文摘 | JOENSUU H ROBERTS PJ SARLOMO-RIKALA M | 2001 | Oncogene2001，20，： | 1 |
| 20 | Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor显示文摘 | Joensuu H Roberts PJ Sarlomo-Rikala M | 2001 | N Engl J Med2001，344，14： | 1 |
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