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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Oxiracetam in dementia a double-blind placebo-controlled study 显示文摘 | Bottini G Vallar G Cappa S | 1992 | Acta Neurol& and1992，86，3： | 1 |
| 3 | Idiom Comprehen- sion: A Prefrontal Task? 显示文摘 | Lauro L J R Tettamanti M Cappa S | 2008 | Cerebral Cortext2008，，18： | 1 |
| 4 | Obstructive sleep apnea: brain structural changes andneurocognitive functions before and after treatment显示文摘 | Canessa N Castronovo V Cappa S | 2011 | Am J Respir Crit Care Med2011，183，10： | 1 |
| 5 | EFNS guidelines on cognitive rehabilitation:report of an EFNS task force显示文摘 | Cappa SF Benke T Clarke S | 2005 | European Journal of Neurology2005，12，9： | 1 |
| 6 | EFNS guidelines on cognitive rehabilitation:report of an EFNS task force显示文摘 | Cappa SF Benke T Clarke S | 2005 | Eur J Neurol2005，12，9： | 1 |
| 7 | Oxiracetam in dementia: a double-blind, placebo-controlled study 显示文摘 | Bottini G Vallar G Cappa S | 1992 | Acta Neurol Scand1992，86，3： | 1 |
| 8 | Efficacy of repetitive transcranial magnetic stimulation/transcranial direct current stimula- tion in cognitive neurorehabilitation显示文摘 | Miniussi C Cappa S F Cohen L G | 2008 | Brain Stimulation2008，1，4： | 1 |
| 9 | Abnormal keratinization of the inner root sheath and cuticles of hair follicles in the scalp with'loose anagen syndrome'显示文摘 | Uno H Cappas A Dong S | 1989 | J Invest Dermatol1989，92，4： | 1 |
| 10 | Prefrontal cortex in long-term memory: an 'interference' approach using magnetic stimulation显示文摘 | ROSSI S CAPPA SF BABILONI C | 2001 | Nat Neurosci2001，，4： | 1 |
| 11 | Crossed aphasis:a PET follow up study of tow cases显示文摘 | Cappa SF Perani D Bressi S | 1993 | J Neurol Neurosury Psychiatr1993，56，： | 1 |
| 12 | EFNS guidelines on cognitive rehabilitation:report of an EFNS task force显示文摘 | Cappa SF Benke T Clarkc S | 2005 | Eur J Neurol2005，12，9： | 1 |
| 13 | Number-Stroop per- formance in normal aging and Alzheimer~-type dementia显示文摘 | Girelli L Sandrini M Cappa S | 2001 | Brain and Cognition2001，46，12： | 1 |
| 14 | EFNS guidelines on cognitive rehabilitation:report of all EFNS task force显示文摘 | Cappa SF Benke T Clarke S | 2005 | Eur J Neurol2005，12，9： | 1 |
| 15 | Obstructive sleep ap- nea:brain structural changes and neuroeognitive function beforeand after treatment显示文摘 | Canessa N Castronovo V Cappa S F | 2011 | Am J Respir Crit Care Med2011，183，10： | 1 |
| 16 | EFNS guidelines on cognitive rehabilitation:report of an EFNS task force显示文摘 | Cappa SE Benke T Clarke S | 2005 | Arch Phys Med Rehabil2005，86，8： | 1 |
| 17 | Influence of vapor wall loss in laboratory chambers on yields of secondary organic aerosol显示文摘 | ZHANG X CAPPA C D JATHAR S H | 2014 | Proceedings of the National Academy of Sciences of the United States of America2014，111，16： | 1 |
| 18 | The bilingual brain as re- ealed by functional neuroimaging 显示文摘 | butalebi J Cappa S F Perani D | 2001 | Bilingualism: Lan- age and Cognition2001，，4： | 1 |
| 19 | Oxiracetam in dementia: a doubleblina, placebor controlled study显示文摘 | Bottini G Vallar G Cappa S | 1992 | Arta Neurot Scand1992，86，3： | 1 |
| 20 | Distinct brain loci in deductive versus probabilistic reasoning显示文摘 | Perani D Cappa S Schnur T Grassi F & Fazio F | 1998 | Neuropsychologia1998，，36： | 1 |
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