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| 1 | Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach显示文摘AIM: To evaluate the ability of Curcuma longa (CL) and Tinospora cordifolia (TC) formulation to prevent anti-tuberculosis (TB) treatment (ATT) induced hepatotoxicity. METHODS: Patients with active TB diagnosis were randomized to a drug control group and a trial group on drugs plus an herbal formulation. Isoniazid, rifampicin, pyrazinamide and ethambutol for first 2 mo followed by continuation phase therapy excluding Pyrazinamide for 4 mo comprised the anti-tuberculous treatment. Curcumin enriched (25%) CL and a hydro-ethanolic extract enriched (50%) TC 1 g each divided in two doses comprised the herbal adjuvant. Hemogram, bilirubin and liver enzymes were tested initially and monthly till the end of study to evaluate the result. RESULTS: Incidence and severity of hepatotoxicity was significantly lower in trial group (incidence: 27/192 vs 2/316, P < 0.0001). Mean aspartate transaminase (AST) (195.93 ± 108.74 vs 85 ± 4.24, P < 0.0001), alanine transaminase (ALT) (75.74 ± 26.54 vs 41 ± 1.41, P < 0.0001) and serum bilirubin (5.4 ± 3.38 vs 1.5 ± 0.42, P < 0.0001). A lesser sputum positivity ratio at the end of 4 wk (10/67 vs 4/137, P = 0.0068) and decreased incidence of poorly resolved parenchymal lesion at the end of the treatment (9/152 vs 2/278, P= 0.0037) was observed. Improved patient compliance was indicated by nil drop-out in trial vs 10/192 in control group (P < 0.0001). CONCLUSION: The herbal formulation prevented hepatotoxicity significantly and improved the disease outcome as well as patient compliance without any toxicity or side effects. | Meghna R Adhvaryu Narsimha M Reddy Bhasker C Vakharia | 2008 | World Journal of Gastroenterology2008，14，30： | 13 |
| 2 | Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis显示文摘难题有交错的脑叶的塑造片的 Arabidopsis 叶人行道房间(PC ) 并且缩排是一个好模型系统调查在纸巾以内协调房间极性和形状形成的机制。植物生长素被显示了 GTPase 依赖的发信号由激活 ROP 协调 interdigitation 小径。识别另外的部件或机制,我们与反常 PC 形态发生为异种屏蔽了并且发现细胞激动素发信号调整 PC interdigitation 模式。在细胞激动素累积的减小和在细胞激动素发信号的缺点(例如在 ARR7-over-expressing 线, ahk3cre1 细胞激动素受体异种,和 ahp12345 细胞激动素表明异种) 提高的 PC interdigitation,而细胞激动素的生产过剩和细胞激动素在一根 ARR20 在表示上线发信号的在激活上在整个子叶推迟了或废除 PC interdigitation。基因、生物化学的分析建议表明 ROP 在上游的行为压制交错的模式的形成的那细胞激动素。我们的结果提供控制 PC 形状的小径的新奇机械学的理解并且揭开为细胞激动素在房间形态发生发信号的一个新角色。 | Hongjiang Li Tongda Xu Deshu Lin Mingzhang Wen M ingtang Xie Jērōme Duclercq Agnieszka Bielach Jungmook Kim G Venugopala Reddy Jianru Zuo Eva Benková Jiгi Friml Hongwei Guoz Zhenbiao Yang | 2013 | Cell Research2013，23，2： | 2 |
| 3 | Spatial Variability of Soil Properties and Weed Population in the Mississippi Delta 显示文摘 | Gaston L A Locke M A Zablotowicz R M Reddy K N | 1999 | Soil Science Bulletin1999，44，8： | 2 |
| 4 | Effect of fodder based complete diets on the rumen fermentation pattern in crossbred bulls显示文摘 | Reddy N M Reddy G V N Reddy M R | 1993 | Indian Journal of Animal Sciences1993，10，1： | 1 |
| 5 | Fast RCS Computation over a Frequency Band Using Method of Moments in Conjunction with Asymptotic Waveform Evaluation Technique显示文摘 | Reddy C J Deshpande M D Cockrell C R | 1998 | IEEE Trans on Antennas and Propagation1998，46，8： | 1 |
| 6 | Optimal operating Schedule of Irrigation Distribution system 显示文摘 | SURYAVANSHI A R REDDY J M | 1986 | Agricultural Water Management1986，11，： | 1 |
| 7 | Indentation penetration and perforation of composite laminates and sandwich panels under quasi-static and projectile loading显示文摘 | Wen H M Reddy T Y Reid S R | 1998 | Key Eng Mater1998，，1： | 1 |
| 8 | Resuspension and diffusive flux of nitrogen and phosphorus in a hypereutrophie lake 显示文摘 | Reddy K R Fisher M M Ivanoff D | 1996 | Journal of Environmental Quality1996，25，36： | 1 |
| 9 | Fractal finite element method based shape sensitivity analysis of mixed-mode fracture显示文摘 | Reddy R M Rao B N | 2008 | Finite Elements in Analysis and Design2008，44，15： | 1 |
| 10 | Alteration of mitochondrial membrane potential by Spirulina platensis C-phycocyanin induces apoptosis in the doxorubicin-resistant human hepatocellular-carcinoma cell line HepG2显示文摘 | ROY K R ARUNASREE K M REDDY N P | 2007 | Biotcclmol Appl Biochem2007，47，3： | 1 |
| 11 | Static and dynamic crushing of foam-filled sheet metal tubes 显示文摘 | Reid S R Reddy T Y Gray M D | 1986 | Int J Mech Sci1986，28，5： | 1 |
| 12 | Penetration and perforation of composite sandwich panels by hemispherical and conical projectiles显示文摘 | Reddy T Y Wen H M Reid S R | 1998 | Trans ASME J Pres Ves Tech1998，120，2： | 1 |
| 13 | Method for Rapid Localization of Seafloor Petroleum Contamination Using Concurrent Mass Spectrometry and Acoustic Positioning 显示文摘 | Camilli R Bingham B Reddy C M | 2009 | Marine Pollution Bulletin2009，，58： | 1 |
| 14 | Deformation and failure of clamped beams under low speed impact loading 显示文摘 | Wen H M Reddy T Y Reid S R | 1995 | Int J Impact Eng1995，16，3： | 1 |
| 15 | Detection of endogenous malondialdehyde-deoxyguanosine adducts in human live 显示文摘 | Chaudhary A K Nokubo M Reddy G R | 1994 | Science1994，265，5178： | 1 |
| 16 | Effect of feeding complete feeds on various nitrogen fraction and total VFA concentration in the rumen fluid of sheep显示文摘 | REDDY K J REDDY M R | 1985 | India J Anim Sci1985，55，9： | 1 |
| 17 | Phosphorus retention by wetland soils used for treated wastewater disposal显示文摘 | Gale P M Reddy K R Graetz D A 1994 | 1994 | J Environ Qual1994，23，： | 1 |
| 18 | Phosphorus sorption capacities of wetland soils and stream sediments impacted by dairy effluent显示文摘 | Reddy K R O'Connor G A Gale P M | 1998 | J Environ Qual1998，27，： | 1 |
| 19 | Modified zirconia solid acid catalysts for organic synthesis and transfor- mations 显示文摘 | REDDY B M SREEKANTH P M REDDY V R | 2005 | J Mol Catalysis A: Chemical2005，225，1： | 1 |
| 20 | Drought-induced re- sponses of photosynthesis and antioxidant metabolism in higher plants 显示文摘 | Reddy A R Chaitanya K V Vivekanandan M | 2004 | J Plant Physiol2004，161，： | 1 |
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