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| 1 | Staging accuracy of esophageal cancer by endoscopic ultrasound:A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in the staging of esophageal cancer. METHODS: Only EUS studies confirmed by surgery were selected. Articles were searched in Medline and Pubmed. Two reviewers independently searched and extracted data. Meta-analysis of the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Forty-nine studies (n = 2558) which met the inclusion criteria were included in this analysis. Pooled sensitivity and specificity of EUS to diagnose T1 was 81.6% (95% CI: 77.8-84.9) and 99.4% (95% CI: 99.0-99.7), respectively. To diagnose T4, EUS had a pooled sensitivity of 92.4% (95% CI: 89.2-95.0) and specificity of 97.4% (95% CI: 96.6-98.0). With Fine Needle Aspiration (FNA), sensitivity of EUS to diagnose N stage improved from 84.7% (95% CI: 82.9-86.4) to 96.7% (95% CI: 92.4-98.9). The P value for the χ2 test of heterogeneity for all pooled estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity in accurately diagnosing the TN stage of esophageal cancer. EUS performs better with advanced (T4) than early (T1) disease. FNA substantially improves the sensitivity and specificity of EUS in evaluating N stage disease. EUS should be strongly considered for staging esophageal cancer. | Srinivas R Puli Jyotsna BK Reddy Matthew L Bechtold Daphne Antillon Jamal A Ibdah Mainor R Antillon | 2008 | World Journal of Gastroenterology2008，14，10： | 55 |
| 2 | How good is endoscopic ultrasound for TNM staging of gastric cancers? A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) for staging of gastric cancers. METHODS: Only EUS studies confirmed by surgery were selected. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Articles were searched in Medline, Pubmed, Ovid journals, Cumulative index for nursing & allied health literature, International pharmaceutical abstracts, old Medline, Medline nonindexed citations, and Cochrane control trial registry. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. 2 × 2 tables were constructed with the data extracted from each study. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specifi city, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fi xed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran's Q test based upon inverse variance weights. RESULTS: Initial search identified 1620 reference articles and of these, 376 relevant articles were selected and reviewed. Twenty-two studies (n = 1896) which met the inclusion criteria were included in this analysis. Pooled sensitivity of T1 was 88.1% (95% CI: 84.5-91.1) and T2 was 82.3% (95% CI: 78.2-86.0). For T3, pooled sensitivity was 89.7% (95% CI: 87.1-92.0). T4 hada pooled sensitivity of 99.2% (95% CI: 97.1-99.9). For nodal staging, the pooled sensitivity for N1 was 58.2% (95% CI: 53.5-62.8) and N2 was 64.9% (95% CI: 60.8-68.8). Pooled sensitivity to diagnose distant metastasis was 73.2% (95% CI: 63.2-81.7). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS results are more accurate with advanced disease than early disease. If EUS diagnoses advanced disease, such as T4 disease, the patient is 500 times more likely to have true anatomic stage of T4 disease. | Srinivas Reddy Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Mainor R Antillon Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，25： | 33 |
| 3 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 4 | Endoscopic ultrasound:It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review显示文摘AIM:To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS:Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS:Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI:82.9-86.4) to 88.0% (95% CI:85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI:83.2-85.9) to 96.4% (95% CI:95.3-97.4). The P forchi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION:EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy. | Srinivas R Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Jamal A Ibdah Daphne Antillon Shailender Singh Mojtaba Olyaee Mainor R Antillon | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 5 | Spatial Variability of Soil Properties and Weed Population in the Mississippi Delta 显示文摘 | Gaston L A Locke M A Zablotowicz R M Reddy K N | 1999 | Soil Science Bulletin1999，44，8： | 2 |
| 6 | Bearing capacity of footings on anisotropic soils显示文摘 | REDDY A S SRINICASAN R J | 1970 | Journal of the Soil Mechanics and Foundations Division ASCE1970，96，6： | 1 |
| 7 | Impact of image guidance on outcomes after external beam radiotherapy for localized prostate cancer 显示文摘 | Kupelian P A Willoughby T R Reddy C A | 2008 | Int J Radiat Oncol Biol Phys2008，70，4： | 1 |
| 8 | Optimal operating Schedule of Irrigation Distribution system 显示文摘 | SURYAVANSHI A R REDDY J M | 1986 | Agricultural Water Management1986，11，： | 1 |
| 9 | DNA helixdestabilization by proline and betaine:possible role in the salinity toleranceprocess显示文摘 | Rajendrakumar C S V Suryanarayana T Reddy A R | 1997 | FEBS Letters1997，410，23： | 1 |
| 10 | Solvent extraction of Hf(IV) from acidic chloride solutions using Cyanex 302显示文摘 | REDDY B R KUMAR J R RAJA K P REDDY A V | 2004 | Minerals Engineering2004，17，： | 1 |
| 11 | DNA helix destabilization by proline and betaine: possible role in the salinity tolerance process显示文摘 | Rajendrakmmar C S V Suryanarayana T Reddy A R | 1997 | FEB S Lett1997，410，： | 1 |
| 12 | Portal vein thrombosis: a concise review显示文摘 | Sobhonslidsuk A Reddy K R | 2002 | Am J Gastroenterol2002，97，3： | 1 |
| 13 | In vitro somatic embryogenesis and regeneration of somatic embryos from pigmented callus of Kappaphycus alvarezii ( Doty ) Doty ( Rhodophyta, Gigartinales) 显示文摘 | Reddy C R K Kumar G Siddhanta A K | 2003 | J Appl Phycol2003，39，： | 1 |
| 14 | Alterations in lipid peroxides in rat liver by dietary n-3 fatty acids:modulation of antioxidant enzymes by curcumin,eugenol,and vitamin E显示文摘 | Reddy A C P Lokesh B R | 1994 | Journal of Nutritional Biochemistry1994，5，： | 1 |
| 15 | Chalcone synthase cDNA from Oryza sativa 显示文摘 | Scheffler B E Reddy A R Hoffmann I | 1995 | Plant Physiol1995，109，： | 1 |
| 16 | Inhibi- tion of aldose reductase preve - nts angiogenesis in vitro and in vivo显示文摘 | Tammali R Reddy A B Srivastava S K | 2011 | Angiogenesis2011，14，： | 1 |
| 17 | Role of Eh and pH on phosphorus geo- chemistry in sediments of Lake Okeechobee, Florida 显示文摘 | MOORE P A REDDY K R | 1994 | Journal of Environmental Quality1994，23，： | 1 |
| 18 | Materials and design development for bipolar/end plates in fuel cells显示文摘 | KUMAR A REDDY R G | 2004 | Journal of Power Sources2004，129，： | 1 |
| 19 | Detection of endogenous malondialdehyde-deoxyguanosine adducts in human live 显示文摘 | Chaudhary A K Nokubo M Reddy G R | 1994 | Science1994，265，5178： | 1 |
| 20 | Effect of gas flow - field design in the bipolar/end plates on the steady and transient state performance of polymer electrolyte membrane fuel cells 显示文摘 | KUMAR A REDDY R G | 2006 | Journal of Power Sources2006，155，2： | 1 |
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