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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 3 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 4 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 5 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy显示文摘 | Vijay K Kuchroo Mercy Prabhu Das Julia A Brown Ann M Ranger Scott S Zamvil Raymond A Sobel Howard L Weiner Nasrin Nabavi Laurie H Glimcher | 1995 | Cell1995，，5： | 2 |
| 6 | Aerobic biodegradation of alkylated aromatic hydrocarbon by a bacterial community 显示文摘 | BUDZINSKI H RAYMOND N NADALIG T | 1998 | Org Geochem1998，28，5： | 1 |
| 7 | AHTN and HHCB show weak estrogenic-butno uterotrophic activity显示文摘 | Willem Seinen Josephine G Lemmen Raymond H HPieters et a1 | 1999 | Toxicology Letters1999，111，： | 1 |
| 8 | Buckling of shallow arches with supports that stiffen when compressed 显示文摘 | RAYMOND H P | 1990 | Journal of Engineering Mechanics1990，116，4： | 1 |
| 9 | Esophageal perforation: surgical, endoscopic and medical management strategies显示文摘 | Boris Sepesi Daniel P Raymond Jeffrey H Peters | 2010 | Current Opinion in Gastroenterology2010，，4： | 1 |
| 10 | The impact of illegal insider trading in dealer and specialist markets: Evidence from a natural experiment显示文摘 | Raymond P H Fishe Michel A Robe | 2004 | Journal of Financial Economics2004，71，： | 1 |
| 11 | Intramolecular versus in termolecular disulfide bonds in prion proteins显示文摘 | Raymond L D Scheraga H A | 2002 | J Biol Chem2002，277，33： | 1 |
| 12 | A non-linear theory of consolidation显示文摘 | DAVIES E H RAYMOND G P | 1965 | Geotechnique1965，15，2： | 1 |
| 13 | Response Surface Methodology-Cur- rent Status and Future Directions 显示文摘 | RAYMOND H MYERS | 1999 | Journal of Quality Technology1999，31，1： | 1 |
| 14 | Genetic and biochemical characterization of field-evolved resistance to Bacillus thuringiensis toxin CrylAc in the diamondback moth,Plutella xylostella显示文摘 | SAYYED A H RAYMOND B IBIZA-PALACIOS M S | 2004 | Appl Environ Microbiol2004，70，12： | 1 |
| 15 | Membrane compliance and liquefaction of sluiced gravel specimens显示文摘 | Evans Mark D Seed H Bnlton Seed Raymond B | 1995 | Journal of Geotechnical Engineering1995，118，6： | 1 |
| 16 | An evaluation of the spectral characteristics of switching converters with chaotic carrier-frequency modulation显示文摘 | TSE K K RAYMOND W M N HENRY S H C | 2003 | IEEE Transactions on Industrial Electronics2003，50，1： | 1 |
| 17 | Tricuspid valve replacement: an analysis of 25 years of experience at a single center显示文摘 | Michel Carrier Yves Hébert Michel Pellerin Denis Bouchard Louis P Perrault Raymond Cartier Arsène Basmajian Pierre Pagé Nancy C Poirier | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 18 | A Non-linear Theory of Consolidation显示文摘 | Davis E H Raymond G P | 1965 | Geotechnique1965，15，2： | 1 |
| 19 | Antiproliferitive effects of recombinant human bone morphogenetic protein-2 on human tuman colonyforming units显示文摘 | Soda H Raymond E Sharma S | 1998 | Anticancer Drugs1998，9，2： | 1 |
| 20 | Two - Dimensional analysis of peeling adhesive tape from human skin 显示文摘 | Raymond H | 2010 | The Journal of Adhesion2010，86，11： | 1 |
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