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| 1 | Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models显示文摘Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(Z.oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods:Five groups of six rats each were selected for the study.Ethanolic extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated groups.The serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of Z.oenoplia roots.Meanwhile,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependency.In addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions:The results of this study slrongly indicate that ethanolic extract of Z.oenoplia has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats. | Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 6 |
| 2 | Treatment of acute goutyarthritis in complex hospitalized patients with anakinra 显示文摘 | Ghosh P Cho M Rawat G | 2013 | Arthritis Care Res (Hoboken)2013，65，8： | 1 |
| 3 | Satellite Detection of Earthquake Thermal Infrared Precursors in Iran显示文摘 | Saraf A k Rawat P | 2008 | Nature Hazard2008，47，： | 1 |
| 4 | Controlling band gap and refractive index in dopant-freeα-Fe2O3Films显示文摘 | KUMAR P RAWAT N HANG D R | 2015 | Electronic Materials Letters2015，11，13： | 1 |
| 5 | Fine root production and turnover in two evergreen central Himalayan forests显示文摘 | Usman S Singh S P Rawat Y S | 1999 | Amals of Botany1999，84，： | 1 |
| 6 | Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures andseizures显示文摘 | Mittal P Manohar R Rawat AK | 2006 | Indian J Pediatr2006，73，11： | 1 |
| 7 | Shikimic acid, a base compound for the formulation of swine/avian flu drug: statistical optimization, fed-batch and scale up studies along with its application as an antibacterial agent 显示文摘 | Tripathi P Rawat G Yadav S | 2015 | Antonie Van Leeuwenhoek2015，107，2： | 1 |
| 8 | Urban forestry for improvement of envi- ronment显示文摘 | Rawat J S Baneriee S P | 1996 | Journal of Energy Environment Monitoring1996，12，2： | 1 |
| 9 | Expanding horizons of shikimic acid : Recent progresses in production and its endless frontiers in application and market trends 显示文摘 | Rawat G Tripathi P Saxena RK | 2013 | Appl Microbio/ Biotechnol2013，97，10： | 1 |
| 10 | In vitro production of phenolic compounds and antioxidant activity in callus suspension cultures of habenaria edgeworthii: a rare Himalayan medicinal orchid显示文摘 | Giri P Dhyani S Rawat | 2012 | Ind Crop Prod2012，39，： | 1 |
| 11 | Faceted and Vertically Aligned GaN Nanorod Arrays Fabricated without Catalysts or Lithography显示文摘 | Deb P Kim H Rawat V | 2005 | Nano Lett2005，5，： | 1 |
| 12 | The multifunctional gly- colytic protein glyceraldehyde-3-phosphate dehydrogenase (GAP- DH) is a novel macrophage lactoferrin receptor显示文摘 | Rawat P Kumar S Sheokand N | 2012 | Biochem Cell Biol2012，90，3： | 1 |
| 13 | Pandemism of swine flu and its prospective drug therapy 显示文摘 | Saxena RK Tripathi P Rawat G | 2012 | Eur J Clin Microbiol Infect Dis2012，31，12： | 1 |
| 14 | Fermentative production of shikimic acid: a paradigm shift of production concept from plant route to microbial route 显示文摘 | Tripathi P Rawat G Yadav S | 2013 | Bioprocess Biosyst Eng2013，36，11： | 1 |
| 15 | Antidyslipidemic activity of polyprenol from Coccinia grandis in high-fat diet-fed hamster model显示文摘 | Singh G Gupta P Rawat P | 2007 | Phytomed2007，14，： | 1 |
| 16 | Cationic transfer- somes based topical geodetic vaccine against hepatitis B 显示文摘 | MAHORS RAWAT A DUBEY P K | 2007 | Int J Pharm2007，340，12： | 1 |
| 17 | Tensile strength of compacted soils显示文摘 | NARAIN J RAWAT P C | 1970 | Journal of the Soil Mechanics and Founda- tions Division1970，96，6： | 1 |
| 18 | Separation of 90Y from 90Sr using zirconium vanadate as the ion exchanger显示文摘 | ROYK MOHAPATRA P K RAWAT N | 2004 | Appl Radiat Isot2004，60，5： | 1 |
| 19 | Action of Asparagus racemosus against streptozotocin-induced oxidative stress显示文摘 | Govindarajan R Vijayakumar M Rao CV Kumar V Rawat AKS Pushpangadan P | 2004 | Nat Prod Sci2004，10，4： | 1 |
| 20 | Collaborative spectrum sen- sing in the presence of Byzantine attacks in cognitive radio networks 显示文摘 | RAWAT A S ANAND P CHEN H | 2011 | IEEE Trans on Signal Processing2011，59，2： | 1 |
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