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| 1 | 双元制职业教育--德国经济竞争力的提升动力显示文摘以国际标准衡量,双元制职业教育属于一种迄今只在少数几个国家达到较高发展水平的职业教育与培训形式。但近年来,很多国家对于引进双元制职业教育模式的兴趣越来越高(Rauner,Smith,2010)。本文将阐释德国的企业、职业联盟、工会组织以及联邦和各州政府坚持这一职教模式并使其实现持续现代化发展的原因。 | 菲利克斯·劳耐尔(Felix Rauner) | 2011 | 职业技术教育2011，32，12： | 46 |
| 2 | Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss显示文摘High erythropoietin(Epo)levels are detrimental to bone health in adult organisms.Adult mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone resorption.In humans,high serum Epo levels are linked to fractures in elderly men.Our earlier studies indicated that Epo modulates osteoblast activity;however,direct evidence that Epo acts via its receptor(EpoR)on osteoblasts in vivo is still missing.Here,we created mice lacking EpoR in osteoprogenitor cells to specifically address this gap.Deletion of EpoR in osteoprogenitors(EpoR:Osx-cre,cKO)starting at 5 weeks of age did not alter red blood cell parameters but increased vertebral bone volume by 25%in 12-week-old female mice.This was associated with low bone turnover.Histological(osteoblast number,bone formation rate)and serum(P1NP,osteocalcin)bone formation parameters were all reduced,as were the number of osteoclasts and TRAP serum level.Differentiation of osteoblast precursors isolated from cKO versus control mice resulted in lower expression of osteoblast marker genes including Runx2,Alp,and Col1a1 on day 21,whereas the mineralization capacity was similar.Moreover,the RANKL70PG ratio,which determines the osteoclast-supporting potential of osteoblasts,was substantially decreased by 50%.Similarly,coculturing cKO osteoblasts with control or cKO osteoclast precursors produced significantly fewer osteoclasts than coculture with control osteoblasts.Finally,exposing female mice to Epo pumps(10 U-d_1)for 4 weeks resulted in trabecular bone loss(-25%)and increased osteoclast numbers(1.7-fold)in control mice only,not in cKO mice.Our data show that EpoR in osteoprogenitors is essential in regulating osteoblast function and osteoblast-mediated osteoclastogenesis via the RANKI70PG axis.Thus,osteogenic Epo/EpoR signaling controls bone mass maintenance and contributes to Epo-induced bone loss. | Martina Rauner Marta Murray Sylvia Thiele Deepika Watts Drorit Neumann Yankel Gabet Lorenz C.Hofbauer Ben Wielockx | 2021 | Bone Research2021，9，4： | 3 |
| 3 | A cross- national comparison and taxonomy of DEA-based hospital efficiency studies显示文摘 | O'Neil L Rauner M Hedidenberger K | 2008 | Soc Econ Plan Sci2008，42，3： | 1 |
| 4 | miR-125b regulates cal- cification of vascular smooth muscle cells 显示文摘 | Goettsch C Rauner M Pacyna N | 2011 | Am J Pathol2011，179，4： | 1 |
| 5 | miR-125b regu- lates calcification of vascular smooth muscle cells 显示文摘 | Goettsch C Rauner M Pacyna N | 2011 | Am J Pathol2011，179，4： | 1 |
| 6 | Minireview: live and let die: molecular effects of glucoeortieoids on bone cells 显示文摘 | Hofbauer LC Rauner M | 2009 | Mol Endocrinol2009，23，10： | 1 |
| 7 | Pathophysiology of osteoporosis显示文摘 | Sipos W Pietschmann P Rauner M | 2009 | Wien Med Wochenschr2009，159，910： | 1 |
| 8 | The osteoclast-associated receptor(OSCAR)is a novel receptor regulated by oxidized lowdensity lipoprotein in human endothelial cells显示文摘 | Goettsch C Rauner M Sinningen K | 2011 | Endocrinology2011，152，12： | 1 |
| 9 | Pathophysiology of osteoporosis 显示文摘 | Sipos W Pietschmann P Rauner M | 2009 | Wien Med Wochenschr2009，159，910： | 1 |
| 10 | Osteoporosis: An Age-Related and Gender - Specific Disease A Mini- Review 显示文摘 | Peter Pietschmann Martina Rauner Wolfgang Sipos | 2009 | Gerontology2009，55，： | 1 |
| 11 | 'If I feel anx- ious, there must be danger' :Ex-consequentia reasoning in inferring danger in anxiety disorders 显示文摘 | ARNTZ A RAUNER M van den Hout M | 1995 | Behaviour Research and Therapy1995，33，： | 1 |
| 12 | WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production显示文摘 | Rauner M Stein N Winzer M | | 0，，03： | 1 |
| 13 | Pathophysiology of osteoporosis显示文摘 | Sipos W Pietschmann P Rauner M | 2009 | Wien Med Wochenschr2009，159，910： | 1 |
| 14 | miR-125b reg- ulates calcification of vascular smooth muscle cells 显示文摘 | GOETTSCH C RAUNER M PACYNA N | 2011 | Am J Pathol2011，179，4： | 1 |
| 15 | An ACO algorithm for a dynamic regional nurse-scheduling problem in Austria显示文摘 | Walter J. Gutjahr Marion S. Rauner | 2005 | Computers and Operations Research2005，，3： | 1 |
| 16 | A crnss-na- tional comparison and taxonomy of DEA-based hospital efficiency studies显示文摘 | O'NE1LL L RAUNER M HE1DENBERGER K | 2008 | Smio-Economic Planning Sciences2008，42，3： | 1 |
| 17 | Denosumab for bone diseases: translating bone biology into targeted therapy 显示文摘 | TSOURDI E RACHNER TD RAUNER M | 2011 | Eur J Endocrinol2011，165，6： | 1 |
| 18 | miR-125b Regulates Calcification of Vascular Smooth Muscle Cells显示文摘 | Claudia Goettsch Martina Rauner Nicole Pacyna Ute Hempel Stefan R. Bornstein Lorenz C. Hofbauer | 2011 | The American Journal of Pathology2011，，4： | 1 |
| 19 | Strategies for novel therapeutic approaches targeting cytokines and signaling pathways of osteoclasto- and osteoblastogenesis in the fight against immune-mediated bone and joint diseases显示文摘 | Sipos W Pietschmann P Rauner M | 2008 | Curr Med Chem2008，15，2： | 1 |
| 20 | The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells显示文摘 | Goettsch C Rauner M Sinningen K | 2011 | Endocrinology2011，152，12： | 1 |
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