|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives显示文摘 | Valérie Haydont Denis Mathé Céline Bourgier Jalil Abdelali Jocelyne Aigueperse Jean Bourhis Marie-Catherine Vozenin-Brotons | 2005 | Radiotherapy and Oncology2005，，2： | 2 |
| 3 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 4 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 5 | Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy 显示文摘 | NATHALIE VALE'RIE N C ANDRE P | 2006 | Am d Respir Crit Care Med2006，174，6： | 1 |
| 6 | Cyclooxygenase-2: a novel target for cancer chemotherapy显示文摘 | Dempke W Rie C Grothey A | 2001 | J Cancer Res Clin Oncol2001，127，7： | 1 |
| 7 | Cyclooxygenase-2: a novel target for cancer chemotherapy? 显示文摘 | Dempke W Rie C Grothey A | 2001 | J Cancer Res Clin Oncol2001，127，7： | 1 |
| 8 | Cyclooxygenase-2:a novel target for cancer chemotherapy显示文摘 | Dempke W Rie C Grothey A | 2001 | J Cancer Res Clin Oncol2001，127，7： | 1 |
| 9 | Cyclooxygenase-2:a novel target for cancer chemotherapy显示文摘 | Dempke W Rie C Grothey A | 2001 | J Cancer Res Clin Oncol2001，127，7： | 1 |
| 10 | Binding sites for Ba- cillus thuringiensis Cry2Ae toxin on heliothine brush border membrane vesicles are not shared with CrylA, CrylF, or Vip3A toxin显示文摘 | Gouffon C van Viler A van Rie J | 2011 | Applied and Environmental Microbiology2011，77，10： | 1 |
| 11 | The application of pH-stat leaching tests to assess the pH-dependent release of trace metals from soils, sediments and waste materials显示文摘 | Val~rie C Rudy S | 2008 | Journal of Hazardous Materials2008，158，： | 1 |
| 12 | Cyclooxygenase-2:a novel target for cancer chemotherapy?显示文摘 | Dempke W Rie C Grothey A | 2001 | J Cancer Res Clin Oncol2001，127，7： | 1 |
| 13 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 1 |
| 14 | Binding sites for Bacillus thuringiensis Cry2Ae toxin on heliothine brush border membrane vesicles are not shared with Cry 1 A, Cry I F, or Vip3 A toxin显示文摘 | Gouffon C van Vliet A van Rie J | 2011 | Applied and Environmental Microbiology2011，77，10： | 1 |
| 15 | Cyclooxygenase- 2: a novel target for cancer chemotherapy? 显示文摘 | DEMPKE W RIE C GROTHEY A | 2001 | J Cancer Res Clin Onal2001，127，7： | 1 |
| 16 | Kallikrein-Related Peptidase 14 Acts on Proteinase-Activated Receptor 2 to Induce Signaling Pathway in Colon Cancer Cells显示文摘 | Valérie Gratio Céline Loriot G. Duke Virca Katerina Oikonomopoulou Francine Walker Eleftherios P. Diamandis Morley D. Hollenberg Dalila Darmoul | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 17 | Cyclooxygenase-2:a novel target for cancer chemotherapy显示文摘 | Dempke W Rie C Grothey A | 2001 | J Cancer Res Clin Onocol2001，127，7： | 1 |
| 18 | Development of titanium diboride coatings deposited by PAVCD 显示文摘 | Pfohl C Bulak A Rie K T | 2000 | Surface and Coatings Technology2000，，131： | 1 |
| 19 | Cyclooxygenase - 2 : a no- vel target for cancer chemotherapy? 显示文摘 | Dempke W Rie C Grothey A | 2001 | J Cancer Res Clin Oncol2001，127，7： | 1 |
| 20 | Cyclooxygenase-2:a novel target for cancer chemotherapy显示文摘 | Rie C Grothey A | 2001 | Cancer Res Clin Oncol2001，127，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员