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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Characteristics of PVD coating on AZ31 hp magnesium alloys显示文摘 | Frank H Renate W Jana S | 2003 | Surface and Coatings Technology2003，162，： | 1 |
| 3 | Comparison of Al-induced gene expression in sensitive and tolerant soybean cultivar显示文摘 | Vladimir E Winfriede W Renate M | 2003 | Journal of Experiment Botany2003，54，： | 1 |
| 4 | Reactivity and toxicity of cyclic sulfuric acid esters显示文摘 | Fischer Gerhard W Jentzsch Renate Kasanzewa Valentina | 1975 | J Prakt Chem1975，317，6： | 1 |
| 5 | Characteristics of PVD-coatings on AZ31HP magnesium alloys显示文摘 | Frank H Renate W Jana S | 2003 | Surf Coat Techn2003，162，： | 1 |
| 6 | Characteristics of PVD-coatings on AZ31hp magnesium alloys显示文摘 | FRANK H RENATE W JANA S | 2003 | Surface and Coatings Technology2003，162，23： | 1 |
| 7 | Analysis of a regulatory element in the 5P-untranslated region of the bcl-2gene显示文摘 | Ines K Renate W Peter P | 1997 | FEBS Letters1997，406，： | 1 |
| 8 | Work loss following stroke显示文摘 | Gabriele W Renate S | 2009 | Disability & Re-habilitation2009，31，14： | 1 |
| 9 | Analysis of a regulatory element in the 5'-untranslated region of the bcl-2 gene显示文摘 | Ines K Renate W Peter P | 1997 | FEBS Letters1997，406，： | 1 |
| 10 | The DNA-binding epidermal growth factor-receptor inihibitor PD153035 and other DNA- intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-β tumor-suppressor gene in breast caner显示文摘 | Thomas WG Katharina T Renate W | 2007 | Differentiation2007，75，88： | 1 |
| 11 | The Influence of Proton Pump Inhibitors on the Antiplatelet Potency of Clopidogrel Evaluated by 5 Different Platelet Function Tests显示文摘 | Thomas Gremmel Sabine Steiner Daniela Seidinger Renate Koppensteiner Simon Panzer Christoph W Kopp | 2010 | Journal of Cardiovascular Pharmacology2010，，5： | 1 |
| 12 | Gay and steffen Gay collagen autoantibodies in patients with vascullitis and systemic lupus erythematosus 显示文摘 | Larry W Moreland Renate E | 1991 | J Clin Immunol Imunopathol1991，60，3： | 1 |
| 13 | Tumor necrosis factor-alpha:alternative role as an inhibitor of osteoclast formation in vitro显示文摘 | Renate B Antoinette W Jeannette P | 2006 | Bone2006，39，2： | 1 |
| 14 | Influence of Air Pollution on Humoral Immune Response 显示文摘 | RENATE S W HELGA L GABRIELE L | 1996 | Journal ofClinical1996，49，52： | 1 |
| 15 | Integerated log interpretation in the German Continental Deep Drilling Program:Lithology,porosity and fracture zones,The KTB deep drill hole显示文摘 | Renate P Susanne H Jurgen W | 1997 | Journal of Geophysical Research1997，102，8： | 1 |
| 16 | Work loss following stroke 显示文摘 | GABRIELE W RENATE S | 2009 | Disabil Rehabil2009，31，18： | 1 |
| 17 | Characteristics of PVD coating on AZ31 hp magnesium alloys显示文摘 | FRANK H RENATE W JANA S | 2003 | Surface and Coatings Technology2003，162，： | 1 |
| 18 | Characteristics of PVD-coatings on AZ31hp magnesium alloys显示文摘 | Frank H Renate W Jana S | 2003 | Surface and Coatings Technology2003，162，23： | 1 |
| 19 | Preparation and thermoelectri ccharacterization of SiC-B4C composites 显示文摘 | Volkmar L Hans-Peter M Renate H W | 2010 | Journal of ElectronicMaferiais2010，39，9： | 1 |
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