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| 1 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 2 | Comparison of antioxidant activity of clove ( Eugenia caryophylata Thunb) buds and lavender ( Lavandula stoechas L.)显示文摘 | ìlhami Gül?in ?. Güng?r ?at ?ükrü Beydemir Mahfuz Elmasta? ?. ?rfan Küfrevio?lu | 2004 | Food Chemistry2004，，3： | 3 |
| 3 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 4 | Characteristic of acoustic emission during stress corrosion cracking of inconel 600 alloy显示文摘 | Key Y S In S K Young K Y | 1997 | Scripta Materialia1997，37，： | 1 |
| 5 | Nanostructures and intermetalliccs, subjected to severe plastic deformation显示文摘 | Valiev R Z Mukherjee unique properties in A K | 2001 | Scr Mater2001，44，： | 1 |
| 6 | Prevalence of sleep disorders breathing in middle-aged Korean men and women显示文摘 | KIM J IN K YOU S | 2004 | J Respir Crit Care Med2004，170，： | 1 |
| 7 | PROOF study Group 显示文摘 | Chesnut CH Silveman S Andviano k A vandomized tial of nasal spay salmon calcitonin in postmenopausal women with established osteporosis: the prevnt recurrence of osteoporasis farcture study | 2000 | Am J Med2000，109，6： | 1 |
| 8 | Outbursts and mines: A review显示文摘 | Shepherd J Rixon L K geological structure in coal Griffiths L | 1981 | Int J Rock Mech Min Sei Geomeb Abstr1981，18，4： | 1 |
| 9 | 2显示文摘 | EVANS H K WYLIE A A MURPHY S K et akThe neuronatin gene resides in a micro-imprinted domain on human chromosome 20ql 1 | 2001 | Genomics2001，77，12： | 1 |
| 10 | Polar Organic Solvent Rem oval in Microcosm Constructed Wet lands 显示文摘 | Grove J K Ste in O R | 2005 | Water Research2005，39，： | 1 |
| 11 | Mammary tumor hetero- myeloid-derived suppressor cells显示文摘 | Moses K Donkor Elaine ct geneity in the expansion of al | 2009 | International Immunopharmacology2009，9，78： | 1 |
| 12 | S3 Guideline: Sedation for gastrointestinal endoscopy 2008显示文摘 | A. Riphaus T. Wehrmann B. Weber J. Arnold U. Beilenhoff H. Bitter S. von Delius D. Domagk A. Ehlers S. Faiss D. Hartmann W. Heinrichs M.-L. Hermans C. Hofmann S. In der Smitten M. Jung G. K?hler M. Kraus J. Martin A. Meining J. Radke T. R?sch H. Seifert A | 2009 | Endoscopy2009，，09： | 1 |
| 13 | Mixed alcohols synthesisfrom syngas over Cs- and Ni-modified Cu/CeOs catalysts显示文摘 | Liu Y Murata K In aba M | 2013 | Fuel2013，104，： | 1 |
| 14 | Ultrasonography screening in 96, 278 unselected employees 显示文摘 | Reiners C Wegscheider K Schicha H Prevalence of thyroid disorders in the working population of Germany | 2004 | Thyroid2004，14，11： | 1 |
| 15 | Shear stress-induced up-regulation of the intermediate-conductance Ca2+-activated K+ channel in human endothelium显示文摘 | Susanne B Anne K Ines E | 2003 | Cardiovasc Res2003，60，： | 1 |
| 16 | Survivin enhances telomerase activity via up - regulation of specificity protein 1 and c-Myc mediated human telomerase reverse transcriptase gene transcription 显示文摘 | Endoh T Tsuj IN Asanuma K | 2005 | Exp Cell Res2005，305，2： | 1 |
| 17 | feces and feathers can indicateintra-individual changes in the diet of migratory songbirds 显示文摘 | Podlesak D W McWilliams S R Hatch K A Stable isotopes in breath blood | 2005 | OecoLogia2005，142，4： | 1 |
| 18 | Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme显示文摘 | Sexton AN Youmans DT Col ins K | | 0，，41： | 1 |
| 19 | Intelligent visual surveillance-a survey显示文摘 | In S K Hong S C Kwang M Y | 2010 | International Journal of Control Automation and Systems2010，8，5： | 1 |
| 20 | Urinary diversion 显示文摘 | World Health Organization (WHO) Conference in Bladder Cancer Hautmann RE Abol-Enein H Hafez K Haro I Mansson W Mills RD Montie JD Sagalowsky AI Stein JP Stenzl A Studer UE Volkmer BG | 2007 | Urology2007，，： | 1 |
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