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| 1 | 贝伐珠单抗联合mFOLFOX6与单独使用mFOLFOX6作为一线治疗用于RAS突变型不可切除的结直肠癌局限性肝转移的随机对照试验显示文摘目的:评估贝伐珠单抗联合氟尿嘧啶、亚叶酸钙和奥沙利铂(mFOLFOX6)作为RAS突变型不可切除的结直肠癌肝转移一线治疗的疗效。方法:将2013年10月至2017年12月伴有RAS突变型不可切除的结直肠癌局限性肝转移患者随机分为mFOLFOX6+贝伐珠单抗治疗组(A组)和单独mFOLFOX6治疗组(B组)。肝转移灶的可切除性由本地的多学科讨论小组商讨决定。该研究的主要终点是肝转移灶经过治疗后转化为R0切除的比率。次要终点包括肿瘤反应、生存率和药物毒性。该研究采用区组随机法。 | 潘杰斌 TANG W T REN L LIU T S | 2020 | 结直肠肛门外科2020，26，5： | 17 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Thermal transformation of δ-MnO_2 nanoflowers studied by in-situ TEM显示文摘在原处,在有一个加热阶段的联合的传播电子显微镜学在直到 665 的在提高的温度的热退火之上以他们的形态学和水晶的结构被采用了到阶段 MnO2 nanoflowers | SUN YuGang LIU YuZi TRUONG Tu T REN Yang | 2012 | Science China Chemistry2012，55，11： | 3 |
| 5 | Calculation of Hydro-Dynamic Stability of the Soil Inside Bucket in the Process of Bucket Foundation Penetration显示文摘—The offshore platform with bucket foundations is a new type of offshore platform that distin-guishes from traditional template platforms by replacing driven piles with bucket foundations.The suctionpenentration of bucket foundation is a complicated hydro-dynamic process.The key of this process is theseepage field caused by the difference of pressure applied on purpose inside and outside the bucket.The ap-pearance and developement of seepage field has a decisive influence on the suction penetration process.Inthis study,the finite element analysis method is applied to the dynamic simulation of the seepage field ofsuction penetration of bucket foundation.A criterion is suggested to distinguish the hydro-dynamic stabili-ty of the soil inside the bucket according to the critical hydraulic gradient method.The reliability of themodel and its applicability to engineering practice have been proved through comparison between the re-sults of model test and finite element calculation. | Yang, SG Xu, T Meng, ZY Ren, GY | 1998 | China Ocean Engineering1998，13，4： | 2 |
| 6 | 生理过度觉醒相关失眠增加高血压风险显示文摘先前的研究显示,失眠和客观睡眠时间过短与高血压风险增加相关,并推测其潜在的机制是生理过度觉醒。在该研究中,研究者通过多次睡眠潜伏期试验(multiplesleeplatencytest,MSLT)——一种睡眠/觉醒的标准测试,探讨与生理过度觉醒相关的失眠是否与高血压风险增加相关。 | Li Y Vgontzas AN Fernandez-Mendoza J Bixler EO Sun Y Zhou J Ren R Li T Tang X 戴伦 练桂丽 | 2015 | 中华高血压杂志2015，23，2： | 2 |
| 7 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 8 | Efficient detection of temporally impulsive dirt impairments in archived films 显示文摘 | J Ch Ren and T Vlachos | 2007 | Signal Processing2007，87，3： | 1 |
| 9 | Targeting Toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients 显示文摘 | Ren T Wen ZK Liu ZM etal | 2008 | Cancer Invest2008，26，5： | 1 |
| 10 | Quantification of rib COL1A2 gene expression in healthy and fluorosed Inner Mongolia cashmere goats显示文摘 | Li W T Yang L F Ren Y C | 2007 | Fluoride2007，40，1： | 1 |
| 11 | Vertical vibration of pile in vibration-induced excess pore pressure field显示文摘 | NOGAMI T REN F CHEN J MASON A | 1997 | Journal of Geotechnical and Geoenvironmental Engineering1997，123，5： | 1 |
| 12 | Substituted tetrapyrazolylporphyrins:Application in organic light-emitting diodes显示文摘 | Guo C C Ren T G Song J X | 2005 | J Porphyrin Phthalocyanine2005，9，12： | 1 |
| 13 | The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts 显示文摘 | Van Rens B T de Groot P N Van Der L T | 2002 | Theriogenology2002，57，6： | 1 |
| 14 | The Jasmonate-ZIM-domain proteins interactwith the WD-Repeat/bHLH/MYB complexes to regulate Jasmonate-medi-ated anthocyanin accumulation and trichome initiation in Arabidopsisthaliana显示文摘 | QI T SONG S REN Q | 2011 | Plant Cell2011，23，5： | 1 |
| 15 | Inhibition of biofihn formation and swarming of Bacillus subtilis by ( 5 Z ) -4 -bromo-5- ( bromomethylmm ) - 3-butyl-2(5n)-furanone显示文摘 | Ren D Sims J J Wood T K | 2002 | Lett Appl Microbiol2002，34，4： | 1 |
| 16 | Research on personalized recommendation based on web usage mining using collaborative filtering technique显示文摘 | Wang T Ren Y | 2009 | WSEAS Transactions on Information Science and Applications2009，6，1： | 1 |
| 17 | Synthesis of Cu-Modified Co2Z Hexaferrite with Planar Structure by a Citrate Precursor Method显示文摘 | Wang X Ren T Li L | 2001 | Journal of Magnetism and Magnetic Materials2001，234，： | 1 |
| 18 | Partial liquid ventilation confers protection against acute lung injury induced by endotoxin in juvenile piglets显示文摘 | Guo ZL Lu GP Ren T | | 0，，3： | 1 |
| 19 | The jasmonate-ZIM-domain proteins interact with the WD-repeat/bHLH/MYB· complexes to regulate jasmonate - mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana显示文摘 | Qi T Sohg S Ren Q | | The Plant C0，，： | 1 |
| 20 | China' s Business Network Structure dur- ing Institutional Transitions显示文摘 | B Ren K Y Au T A Birtch | 2009 | Asia Pac J Manag2009，，26： | 1 |
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