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| 1 | Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver:A retrospective study显示文摘AIM:To investigate the efficacy and toxicity of systemic chemotherapy in a retrospective study of patients with hepatocellular carcinoma(HCC)occurring in normal or fibrotic liver without cirrhosis. METHODS:Twenty-four patients with metastatic or locally advanced HCC in a normal or a fibrotic liver were given systemic chemotherapy(epirubicin,cis- platin and 5-fluorouracil or epirubicin,cisplatin and capecitabine regimens).Tumor response,time to pro- gression,survival,and toxicity were evaluated. RESULTS:There were 7 women and 17 men,mean age 54±10 years;18 patients had a normal liver and 6 had a fibrotic liver(F1/F2 on biopsy).Mean tumor size was 14 cm,5 patients had portal vein thrombosis and 7 had metastasis.Patients received a median of 4 chemotherapy sessions.Overall tolerance was good. There were 5 partial responses(objective response rate =22%),and tumor control rate was 52%.Second line surgical resection was possible in two patients.Median survival was 11 mo,and 1-and 2-year overall survival rates were 50%±10%and 32%±11%,respectively. CONCLUSION:In patients with HCC in a non-cirrhotic liver,chemotherapy was well tolerated and associated with an objective response rate of 22%,including two patients who underwent secondary surgical resection. | Julien Edeline Jean-Luc Raoul Elodie Vauleon Anne Guillygomac'h Karim Boud jema Eveline Boucher | 2009 | World Journal of Gastroenterology2009，15，6： | 4 |
| 2 | Unbalance compensation using generalized notch filters in the multivariable feedback of magnetic bearing显示文摘 | Raoul H Conrad G Rene L | 1996 | IEEE Transactions on Control Systems Technology1996，4，： | 1 |
| 3 | The light-hyperresponsive high pigment-2dg mutation of tomato: alterations in the fruit metabolome 显示文摘 | Raoul J B Ric de C H V Michal L | 2005 | New Phytologist2005，166，： | 1 |
| 4 | Unbalance compensation using generalized notch fil- ters in the multivariable feedback of magnetic bear- ings 显示文摘 | RAOUL H PHILIPP B CONRAD G | 1996 | IEEE Transactions on Control Systems Technology1996，4，5： | 1 |
| 5 | Unbalance compensation using generalized notch filters in the multivariable feedback of magnetic bearings显示文摘 | Raoul H Philipp B Conrad G | 1996 | IEEE Transactions on Control Systems Technology1996，4，5： | 1 |
| 6 | New Results for Serf - Sensing Active Magnetic Bearings Using Modula- tion Approach 显示文摘 | Alexandre S Raoul H Philipp u | 2005 | IEEE Transactions on Control Sys- tems Technology2005，13，4： | 1 |
| 7 | Rapid solid-phase extraction method for the detection of volatile nitrosamines in food显示文摘 | RAOUL S GREMAUD E BIAUDET H | 1997 | Journal of Agricultural and Food Chemistry1997，45，12： | 1 |
| 8 | Clinical impact of programmed cell death ligand 1 expression in colorectal cancer显示文摘 | Raoul A. Droeser Christian Hirt Carsten T. Viehl Daniel M. Frey Christian Nebiker Xaver Huber Inti Zlobec Serenella Eppenberger-Castori Alexander Tzankov Raffaele Rosso Markus Zuber Manuele Giuseppe Muraro Francesca Amicarella Eleonora Cremonesi Michael H | 2013 | European Journal of Cancer2013，，9： | 1 |
| 9 | The dynamical information underpinning anticipation skill显示文摘 | WILLIAMS M A RAOUL H RULAND R C | 2009 | Human Movement Science2009，，28： | 1 |
| 10 | Global Information Pickup Underpins Anticipation of Tennis Shot Direction 显示文摘 | RAOUL H BRULAND R C HAGEMANN N | 2009 | Journal of Motor Behavior2009，，41： | 1 |
| 11 | Pattern of nodal metastasis for primary and reoperative thyroid cancer显示文摘 | Andreas M Raoul H Oliver T | 2002 | World J Surg2002，26，1： | 1 |
| 12 | Hysteroscopy combined with hysterosalpingo-contrast sonography(HyCoSy):a new modality for comprehensive evaluation of the female pelvic organs显示文摘 | Eran H Raoul David R | | 0，，： | 1 |
| 13 | Unbalance compensation using generalized notch filters in the multivariable feedback of magnetic bearings显示文摘 | Raoul H | 1996 | IEEE Transactions on Control Systems Technology1996，4，5： | 1 |
| 14 | Hysteroscopy combined with hys-terosalpingo contrast sonography (HyCoSy):a new modality forcomprehensive evaluation of the female pelvic organs显示文摘 | Eran H Raoul O David R | 2006 | Gyneco-logical Endocrinology2006，22，4： | 1 |
| 15 | The Dynamical Information Underpinning Anticipation Skill 显示文摘 | Mark A W Raoul H Rouwen C B | 2009 | Human Movement Science2009，28，3： | 1 |
| 16 | Using machine learning models to explore the solution space of large nonlinear systems underlying flowsheet simulations with constraints显示文摘Flowsheet simulations of chemical processes on an industrial scale require the solution of large systems of nonlinear equations,so that solvability becomes a practical issue.Additional constraints from technical,economic,environmental,and safety considerations may further limit the feasible solution space beyond the convergence requirement.A priori,the design variable domains for which a simulation converges and fulfills the imposed constraints are usually unknown and it can become very time-consuming to distinguish feasible from infeasible design variable choices by simply running the simulation for each choice.To support the exploration of the design variable space for such scenarios,an adaptive sampling technique based on machine learning models has recently been proposed.However,that approach only considers the exploration of the convergent domain and ignores additional constraints.In this paper,we present an improvement which particularly takes the fulfillment of constraints into account.We successfully apply the proposed algorithm to a toy example in up to 20 dimensions and to an industrially relevant flowsheet simulation. | Patrick Otto Ludl Raoul Heese Johannes Höller Norbert Asprion Michael Bortz | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 1 |
| 17 | After-effects of Human-com- puter Interaction Indicated by P300 of the Event- related Brain Potentia L 显示文摘 | Michael T Raoul H | 1998 | Ergonomics1998，41，5： | 1 |
| 18 | Rapid solid-phase extraction method for the detection of volatile nitrosamines in food 显示文摘 | Raoul S Gremaud E Biaudet H | 1997 | Journal of Agricultural and Food Chemistry1997，45，12： | 1 |
| 19 | Emergence of Zaire ebola virus disease in Guinea-Preliminary report 显示文摘 | Baize S Pannetier D Oestereich L Rieger T Koivogui L Magassouba N Soropogui B Sow MS Keita S De Clerck H Tiffany A Dominguez G Loua M Traore A Kolie M Malano ER Heleze E Bocquin A Mely S Raoul H Caro V Cadar D Gabriel M Pahlmann M Tappe D Schmidt- Chanasit J Impouma B Diallo AK Formenty P Van Herp M G/inther S | 2014 | N Engl J Med2014，371，15： | 1 |
| 20 | Unbalance compensation using generalized notch filters in the multivariable feedback of magnetic bearings显示文摘 | RAOUL H | 1996 | IEEE Transaction on Control Systems Technology1996，4，5： | 1 |
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