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| 1 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Tumor specificmodulation of Ku70/80 DNA binding activity in breastand bladder hurnan tumor biopsies显示文摘 | Pucci S Mazzareili P Rabitti C | 2001 | Oncogene2001，20，6： | 1 |
| 3 | Prophylaxis wilh meropenem of septiccomplications in acute pancreatitis: a ran domized, controlledtrial versus imipenem显示文摘 | Manes G Rabitti PG Menchise A | 2003 | Pancreas2003，27，： | 1 |
| 4 | Cetuximab and irinotecan as third-line therapy in advanced colorectal cancer patients: a single centre phase II trial 显示文摘 | Vincenzi B Santini D Rabitti C | 2006 | BrJ Cancer2006，94，： | 1 |
| 5 | Mortality in acutepancreatitis:is it an early or a late event显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | JOP2005，6，5： | 1 |
| 6 | Tumor specific modulation of KU70/80 DNA binding activity in breast and bladder human tumor biopies 显示文摘 | Pucci S Mazzarelli P Rabitti C | 2001 | Oncogene2001，20，6： | 1 |
| 7 | Prognostic impact of VEGF,CD31,CD34,and CD105 expression and tumour vessel invasion after radical surgery for IB-ⅡA non-small cell lung cancer显示文摘 | Mineo TC Ambrogi V Baldi A Rabitti C Bol ero P Vincenzi B | 2004 | J Clin Pathol2004，57，6： | 1 |
| 8 | Mortality in acute pan- creatitis: is it an early or a late even显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | JOP2005，6，5： | 1 |
| 9 | Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo显示文摘 | Rabitti D Presta M Vacca A | 1999 | Blood1999，93，8： | 1 |
| 10 | Stream-scanning laser system, electric sensing counter and settling grain Size analysis: a comparison using reference materials and marine sediments 显示文摘 | Emanuela Molinaroli Giovanni De Falco Sandro Rabitti | 2000 | Sedimentary Geology2000，130，： | 1 |
| 11 | Anorexia-cachexia syn- drome in pancreatic cancer: recent development in re- search and management显示文摘 | Uomo G Gallucci F Rabitti PG | 2006 | JOP2006，7，2： | 1 |
| 12 | Lack of gastric adverse effects of erdostein in rats and men显示文摘 | Giovanni DL Fregnan GB Rabitti G | 1991 | Int J Clin Pharmacol Ther Toxicol1991，29，7： | 1 |
| 13 | Mortality in acute pancreatitis: is it an early or a late event?显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | JOP2005，6，5： | 1 |
| 14 | Martality in acute pancreatilis:is it an early or a late event显示文摘 | CARNOVALE A RABITTI PG MANES G | | 0，，05： | 1 |
| 15 | Cetuximad and irinotecan as third line therapy in advanced colorectal cancer patients:a single center phase Ⅱ trial显示文摘 | Vincenzi B Santini D Rabitti C | 2006 | Br J Cancer2006，94，6： | 1 |
| 16 | Lymphatic Spread of Cervical Cancer: An Anatomical and Pathological Study Based on 225 Radical Hysterectomies with Systematic Pelvic and Aortic Lymphadenectomy显示文摘 | P. Benedetti-Panici F. Maneschi G. Scambia S. Greggi G. Cutillo G. D’Andrea C. Rabitti F. Coronetta A. Capelli S. Mancuso | 1996 | Gynecologic Oncology1996，，1： | 1 |
| 17 | HER2 amplification status in gastric and gastro‐oesophageal junction cancer in routine clinical practice: which sample should be used?显示文摘 | Giuseppe Perrone Michelina Amato Marcella Callea Carla Rabitti Daniela Righi Pierfilippo Crucitti Roberto Coppola Andrea Onetti Muda | 2012 | Histopathology2012，，1： | 1 |
| 18 | Plasma calprotectin levels in patients suffering from acute pancreatitis显示文摘 | Carroccio A Rocco P Rabitti PG | 2006 | Dig DisSci2006，51，10： | 1 |
| 19 | Tumor specific modulation of KU70/80 DNA binding activity in breast and bladder human tumor biopsies显示文摘 | Pucci S Mazzarelli P Rabitti C | 2001 | Oncogene2001，20，6： | 1 |
| 20 | Mortality in acute pan-crent显示文摘 | Camovale A Rabitti PG Manes Gatitis | 2005 | JOP2005，6，5： | 1 |
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