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| 1 | Evaluation of an extracellular matrix-derived acellular biphasic scaffold/cell construct in the repair of a large articular high-load-bearing osteochondral defect in a canine model显示文摘 | YANG Qiang PENG Jiang LU Shi-bi GUO Quan-yi ZHAO Bin ZHANG Li WANG Ai-yuan XU Weng-jing XIA Qun MA Xin-long HU Yong-cheng XU Bao-shan | 2011 | Chinese Medical Journal2011，，23： | 15 |
| 2 | Progress in the Research and Manufacture of GH4169 Alloy显示文摘GH4169 alloy has been widely used in fields such as aviation, aerospace, and petrochemical, because of its excellent combination of mechanical and processing properties. These properties include good high-temperature strength, excellent creep and fatigue resistance, and good processing and welding performance. The requirement for high performance, high reliability, and long service life of modern engines has led to the incentive to develop GH4169 alloys with improved performance, such as increased temperature-bearing capacity, improved creep endurance, and better fatigue resistance. Advances during the past thirty years in basic research and industrial technology related to GH4169 alloy were systematically summarized, including advances in alloy modification, melting process optimization, and hot deformation technology. | Jin-hui DU Xu-dong LU Qun DENG Zhong-nan BI | 2015 | Journal of Iron and Steel Research(International)2015，22，8： | 14 |
| 3 | Relationship between structure and function of JWA in the modulation of cell differentiation显示文摘To elucidate the structure characteristic, regulation of expression and the potential function of JWA——anovel rctinoic acid responsible and cytoskeleton associate gene, a rat JWA homologue gene and a 621-bp JWA promoter fragment were cloned and analyzed. Using reverse transcription-polymerase chain reaction (RT-PCR), JWA mRNA expression in NIH3T3, K562 and human primary acute promyelocytic leukaemia (APL) cells have been investigated after treatment with all trans retinoic acid (ATRA), N-4-hydroxyphenyl-retinamide (4HPR), arsenic trioxide (As2O3), Phorbol-12-myristate-13-acetate (TPA) and dimethyl sulfoxide (DMSO). The results showed that there is a complete TPA responsive element (TRE) existed in the promoter of JWA at -437 to -443 bp; rat JWA homologue gene showed that there are four nucleotides different from human JWA within coding region. After treatment with TPA, an uneven pattern of JWA transcription existed in different cell lines, suggesting that even TPA induces cell differentiation in | XIA Wei ZHOU Jianwei CAO Haixia ZOU Changping WANG Chengya SHEN Qun LU Hua | 2001 | Chinese Science Bulletin2001，46，24： | 11 |
| 4 | Role of JWA in acute promye-locytic leukemia cell differentiation and apoptosis triggered by retinoic acid,12-tetradecanoylphorbol-13- acetate and arsenic trioxide显示文摘JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecano-ylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10-6 mol/L) and As2O3 (10-6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10-6mol/L) and TPA (10-7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ | CAO Haixia XIA Wei SHEN Qun LU Hua YE Jian LI Aiping ZOU Changping ZHOU Jianwei | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 5 | Improvement of cardiac function and reversal of gap junction remodeling by Neuregulin-1β in volume-overloaded rats with heart failure显示文摘ObjectiveWe 用 Neuregulin-1β 执行了实验;(NRG-1β) 决定为保护的角色的机制由在 .MethodsRat HF 建模的心失败(HF ) 期间改变差距连接(GJ ) 源于它的有益的效果的处理被 aortocaval 建立管。48 只老鼠随机被划分成 HF (HF, n = 16 ) , NRG-1β处理(NRG, n = 16 ) ,并且假冒的操作(S, n = 16 ) 组。在 NRG 组的老鼠是管理 NRG-1β(10 µ g/kg 每天) 为经由尾巴静脉的 7 天,而另外的组与一样的剂量被注射盐。在操作以后的 12 个星期,在从左室获得的单个 myocytes 的 Connexin 43 (Cx43 ) 表示被 immunocytochemistry 决定。全部的蛋白质为 immunoblotting 试金从冻结的左室的纸巾被提取,并且 myocytes 的超微结构被传播电子 microscopy.ResultsCompared 与 HF 组,一起观察在 NRG 组的老鼠的心脏的功能显著地被改进的、不规则的分发和死亡 Cx43 表示被减轻。myocytes 的超微结构严重在 HF 老鼠,和 NRG-1β 被损坏;减少了这些病理学的 damages.ConclusionsShort 术语 NRG-1β在体积的试验性的模型的处理罐头营救泵失败导致超载的 HF,它与 GJ 结构和 Cx43 的改进的恢复有关表示。 | Xue-Hui Wang Xiao-Zhen Zhuo Ya-Juan Ni Min Gong Ting-Zhong Wang Qun Lu Ai-Qun Ma | 2012 | Journal of Geriatric Cardiology2012，9，2： | 10 |
| 6 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 7 | The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells显示文摘Neogambogic 酸(NGA ) ,在 garcinia 的活跃成分,能在 anticancer 效果禁止一些稳固的肿瘤和结果的生长。我们假设那 NGA 可能为人的乳癌房间线 MCF-7 房间的增长的抑制负责。在 vitro 调查它的 anticancer 机制, MCF-7 房间与 NGA 的各种各样的集中被对待。试金显示出的 MTT (甲基 thiazolyl tetrazolum ) 的结果有 NGA 的那治疗显著地以一种剂量依赖者方式减少了 MCF-7 房间的增长。NGA 能增加 anti-apoptotic 蛋白质 Bcl-2 的表示由 mitochondrial transmembrane 损坏伴随了的 apoptosis 相关的蛋白质 FasL, caspase-3, caspase-8, caspase-9,和 Bax 和减少的表示。MCF-7 房间上的 NGA 的 antiproliferative 效果由于 Fas/FasL 和细胞色素 C 小径的 G0/G1 拘捕,增加的 apoptosis 和激活。这些结果提供重要卓见进 NGA 通过损害乳癌房间的增长的细胞、分子的机制。 | Keming Wang Yuhong Tang Ming Sun Binbin Lu Hongqin Zhu Ou Ji Qun Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 9 |
| 8 | Soybean AP1 homologs control flowering time and plant height显示文摘Flowering time and plant height are key agronomic traits that directly affect soybean(Glycine max)yield.APETALA1(AP1)functions as a class A gene in the ABCE model for floral organ development,helping to specify carpel,stamen,petal,and sepal identities.There are four AP1 homologs in soybean,all of which are mainly expressed in the shoot apex.Here,we used clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein 9 technology to generate a homozygous quadruple mutant,gmap1,with loss-of-function mutations in all four GmAP1 genes.Under short-day(SD)conditions,the gmap1 quadruple mutant exhibited delayed flowering,changes in flower morphology,and increased node number and internode length,resulting in plants that were taller than the wild type.Conversely,overexpression of GmAP1a resulted in early flowering and reduced plant height compared to the wild type under SD conditions.The gmap1 mutant and the overexpression lines also exhibited altered expression of several genes related to flowering and gibberellic acid metabolism,thereby providing insight into the role of GmAP1 in the regulatory networks controlling flowering time and plant height in soybean.Increased node number is the trait with the most promise for enhancing soybean pod number and grain yield.Therefore,the mutant alleles of the four AP1 homologs described here will be invaluable for molecular breeding of improved soybean yield. | Liyu Chen Haiyang Nan Lingping Kong Lin Yue Hui Yang Qingsong Zhao Chao Fang Haiyang Li Qun Cheng Sijia Lu Fanjiang Kong Baohui Liu Lidong Dong | 2020 | Journal of Integrative Plant Biology2020，62，12： | 9 |
| 9 | ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity显示文摘We investigated the relationship of apoB/apoA1 ratio and coronary heart disease (CHD) in persons who were overweight or obese.The subjects were divided by the body mass indexes (BMI) into the normal weight group (n=397,BMI<24 kg/m 2) and the overweight group (n=400,BMI>24 kg/m 2).Our results showed that the overweight group had higher blood pressure [(130.15±19.01) mmHg vs (123.66±18.70) mmHg] and higher levels of blood sugar [(7.09±2.89) mmol/L vs (6.21±2.59) mmol/L],triglyceride [(1.93±1.19) mmol/L vs (1.44±0.85) mmol/L],total cholesterol [(4.26±1.06) mmol/L vs (4.09±0.99) mmol/L],low-density lipoprotein cholesterol (LDL-C) [(2.56±0.75) mmol/L vs (2.39±0.72) mmol/L],and apoB [(0.83±0.27) mg/L vs (0.78±0.23) mg/L],and a higher apoB/apoA1 ratio (0.83±0.27 vs 0.75±0.25) and lower levels high-density lipoprotein cholesterol [(1.10±0.26) mmol/L vs (1.21±0.31) mmol/L] and apoA1 [(1.04±0.20) mg/L vs (1.08±0.22) mg/L] than those of the normal weight group (all P < 0.05).The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile,compared with the subjects in the lowest apoB/apoA1 quartile.The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD.In the overweight and obesity group,the area under ROC curve (AUC) was the highest for apoB/apoA1 (0.655).The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80,with a sensitivity of 57.19% and a specificity of 71.72%.In conclusion,apoB and apoA1 were simple clinical indicators,and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients.The apoB/apoA1 ratio may provide some useful information in the differential diagnosis. | Min Lu Qun Lu Yong Zhang Gang Tian | 2011 | The Journal of Biomedical Research2011，25，4： | 8 |
| 10 | Acquisition of deleterious mutations duringpotato polyploidization显示文摘Potatoes(Solanum tuberosum L.) represent an important tuber crop, worldwide. During its prolonged clonal propagation, numerous deleterious mutations have accumulated in the potato genome,leading to severe inbreeding depression; however,the shaping of this mutation burden during polyploidization and improvement is largely unknown.Here, we sequenced 20 diploid landraces of the Stenotomum group, eight tetraploid landraces, and 20 tetraploid modern cultivars, to analyze variations in their deleterious mutations. We show that deleterious mutations accumulated rapidly during the polyploidization of tetraploid potatoes. This study provides a foundation for future potato improvement. | Qun Lian Die Tang Zhiyan Bai Jianjian Qi Fei Lu Sanwen Huang Chunzhi Zhang | 2019 | Journal of Integrative Plant Biology2019，61，1： | 8 |
| 11 | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics显示文摘Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics;however,fabricating adhesive hydrogels with multiple functions remains a challenge.In this study,a mussel-inspired tannic acid chelated-Ag(TA-Ag)nanozyme with peroxidase(POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles(NPs)with TA.The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid.The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone,providing the hydrogels with long-term and repeatable adhesiveness,similar to the adhesion of mussels.The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network,thereby improving its mechanical properties and conductivity.Furthermore,the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag.Owing to these advantages,the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive,antibacterial,and implantable bioelectrode to detect bio-signals,and as a wound dressing to accelerate tissue regeneration while preventing infection.Therefore,this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis. | Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu | 2021 | Bioactive Materials2021，6，9： | 7 |
| 12 | Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats显示文摘Amyloid β-peptide(Aβ) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer 's disease(AD). Humanin(HN) is a secretory peptide that inhibits the neurotoxicity of Aβ. However, the mechanism(s) by which HN exerts its neuroprotection against Aβ-induced ADlike pathological changes and memory deficits are yet to be completely defined. In the present study,we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ1-42. HN also attenuated Aβ1-42-induced tau hyperphosphorylation,apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A(PP2A)catalytic subunit and thereby activating PP2 A. HN also inhibited apoptosis and reduced the oxidativestress induced by Aβ1-42. These findings provide novel mechanisms of action for the ability of HN to protect against Aβ1-42-induced AD-like pathological changes and memory deficits. | Gao-Shang Chai Dong-Xiao Duan Rong-Hong Ma Jian-Ying Shen Hong-Lian Li Zhi-Wei Ma Yu Luo Lu Wang Xin-Hua Qi Qun Wang Jian-Zhi Wang Zelan Wei Darrell D.Mousseau Li Wang Gongping Liu | 2014 | Neuroscience Bulletin2014，30，6： | 7 |
| 13 | Comparative analysis of different cyclosporine A doses on protection after myocardial ischemia/reperfusion injury in rat显示文摘Objective:To investigate the protective effect of different cyclosporin A(CsA)doses on myocardial ischemia/reperfusion injury in rat models.Methods:A rat model of myocardial ischemia/reperfusion injury was established in vivo and the rats were randomly divided into four groups:placebo(PBS;T1),low-dose(CsA dose:1.0 mg/kg:T2),medium-dose(CsA dose:2.5 mg/kg:T3),and high-dose(CsA dose:5.0 mg/kg;T4)groups.Heart function indexes were monitored at different time points,the extent of myocardial infarction was assessed by Evans Blue-TTC staining,and creatine kinase MB mass and cardiac troponin 1 values were measured by biochemical assays.Results:Compared with the T1 and T2 groups,both the creatine kinase MB mass and cardiac troponin 1 were significantly lower in the T3 and T4 groups(P<0.05).The mean arterial pressure(MAP)and left ventricular systolic pressure(LVSP)decreased sequentially in each group,with the extending reperfusion time.Significant decreases in LVSP and MAP were observed in the T3 and T4 groups as compared to the T1 and T2 group(P<0.05)and the T2 group showed a significantly lower LVSP and MAP decline than the T1 group(P<0.05).Compared with the Tl group,the rats from the T2.T3,and T4 groups suffered from a significantly lower extent of myocardial infarction(P<0.05).Also,the a animals in the T3 and T4 groups had a significantly smaller extent of myocardial infarction than those in the T2 group(P<0.05).Conclusions:Various CsA doses exert different degrees of protection against ischemia/reperfusion injury,and this protective effect peaks at approximately 2.5 mg/kg in rat models. | Kang Huang Shi-Juan Lu Jiang-Hua Zhong Qun Xiang Liu Wang Miao Wu | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，2： | 6 |
| 14 | Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure显示文摘Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure (HF).We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volumeoverload operation followed with pressure-overload.The reversible effect of these changes with bisoprolol was also evaluated.The HF group exhibited left ventricular enlargement,systolic dysfunction,prolongation of corrected QT interval (QTc),and increased plasma brain natriuretic peptide levels in the HF rabbits.Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits.After bisoprolol treatment,heart function was improved significantly and QTc was shortened.Additionally,the mRNA expression of potassium channel subunit genes could be partially reversed.The down-regulated expression of potassium channel subunits Kv4.3,Kv1.4,KvLQT1,minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF.Bisoprolol could partially reverse these down-regulations and improve heart function. | Xi Li Tingzhong Wang Ke Han Xiaozhen Zhuo Qun Lu Aiqun Ma | 2011 | The Journal of Biomedical Research2011，25，4： | 6 |
| 15 | Cytotoxic effects of mono-(2-ethylhexyl) phthalate on human embryonic stem cells显示文摘 | SHI Cheng CHEN Xi CAI Xiao-hui YU Wei-dong LIANG Rong LU Qun SHEN Huan | 2013 | Chinese Medical Journal2013，，9： | 6 |
| 16 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 17 | Preparation,structural characterization of a novel egg-shell palladium sulfide catalyst and its application in selective reductive alkylation reaction显示文摘有核心和钯硫化物的膜被 sulphidizing Pd/C 与 H2S 作为表面准备了的钯金属的新奇卵壳 PdS 催化剂。这催化剂是有效的让 p 氨基的二苯胺(PADPA ) 和 methylisobutyl 酉同类(MIBK ) 的减少的完化负担得起 N-(1,3-dimethylbutyl ) 有直到 99.42% 的变换和到 97.46% 的选择的 -N-phenyl-p-phenylenedianine (DBPPD ) 。与另外的普通的钯硫化物催化剂作比较,表面上的硫化物和钯金属的核心在更低的硫协作在新催化剂的表面上引起 Pd 的钯的膜,它改进它的活动。我们的结果显示这新卵壳 PdS/C 是有效加氢催化剂。 | Qun Feng Zhang Jia Chun Wu Chang Su Feng Feng Qiao Ling Ding Zhao Lian Yuan Hong Wang Lei Ma Chun Shan Lu Xiao Nian Li | 2012 | Chinese Chemical Letters2012，23，10： | 5 |
| 18 | Pregnancy outcomes after fertility preservation in women with endometrial carcinoma and atypical endometrial hyperplasia:A systematic review and meta-analysis显示文摘Objective:The objective of the study was to compare the effects of assisted reproductive technology(ART)and spontaneous pregnancy on pregnancy outcomes in women with endometrial carcinoma(EC)and atypical endometrial hyperplasia(AEH)following fertility-sparing treatments.Methods:Relevant studies published through July 2020 were identified from PubMed and Web of Science literature searches.The pregnancy outcomes of ART and spontaneous pregnancy were summarized and compared for women with complete remission of EC/AEH after fertility-sparing treatments.A subgroup analysis was performed based on whether patients had received in vitro fertilization and embryo transfer(IVF-ET)treatment.The complete remission and recurrence rates of EC/AEH following fertility-sparing treatments were estimated.The effect of pregnancy on recurrence rates of EC/AEH was also calculated.Results:Sixteen observational studies reporting pregnancy outcomes or recurrence with ART or spontaneous pregnancy for women with EC/AEH after fertility-sparing treatments were included.The complete remission rate of EC/AEH was 81.5%(95%CI,78%–85%).Compared with spontaneous pregnancy,the pregnancy rate of ART was significantly higher(66.8%vs.43.7%,OR=2.64,95%CI 1.71–4.05,P<0.00001,I^(2)=14%).Subgroup analysis showed that the pregnancy rate of IVF-ET was significantly higher than that of spontaneous pregnancy(62.7%vs.35.1%,OR=2.85,95%CI 1.44-5.63,P=0.003,I^(2)=29%).The live birth rate of ART was significantly higher than that of spontaneous pregnancy(75.3%vs.47.8%,OR=3.96,95%CI1.76-8.77,P=0.0009,I^(2)=45%).The recurrence rate of EC/AEH was 31%(95%CI 24%–39%).Clinical pregnancy could reduce the recurrence rate of EC/AEH,but there was no significant evidence of an association.Conclusions:ART,especially IVF-ET,could significantly improve pregnancy outcomes in women with EC/AEH receiving fertility-sparing treatments.Following complete remission,ART treatment might be a better option for women with EC/AEH than spontaneous pregnancy. | Zerui Xiao Ziyi Song Jianliu Wang Huixin Liu Qun Lu | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，4： | 4 |
| 19 | In vitro cartilage production using an extracellular matrix-derived scaffold and bone marrow-derived mesenchymal stem cells显示文摘 | ZHAO Yan-hong YANG Qiang XIA Qun PENG Jiang LU Shi-bi GUO Quan-yi MA Xin-long XU Bao-shan HU Yong-cheng ZHAO Bin ZHANG Li WANG Ai-yuan XU Weng-jing MIAO Jun LIU Yue | 2013 | Chinese Medical Journal2013，，16： | 4 |
| 20 | Cloning,expression and function of phosphate transporter encoded gene in Oryza sativa L.显示文摘OsPT6:1,a phosphate transporter encoding gene from the leaf samples of Oryza sativa, was identified through PCR with specifically designed primers.The phylogenetic analysis and the conserved amino acid residue site detection suggested OsPT6:1 a possible high-affinity phosphate transporter encoding gene.In situ hybridization and RT-PCR demonstrated the expression of OsPT6:1 in both roots and leaves.The peak expression signal was observed in mesophyll cells under low phosphorus(P)induction.A homologous recombination study indicated that OsPT6:1 can enhance the Pi uptake efficiency of Pichia pastoris.At the meantime,the introduction of OsPT6:1 was able to complement the Pi uptake function of yeast cells with high-affinity phosphate transporters de- ficient.Those results substantiated our contention that OsPT6:1 encoded a high-affinity phosphate transporter of Oryza sativa. | MING Feng 1,2* ,LU Qun 1,2* ,WANG Wei 1,2* ,ZHANG Shanshan 1,2 ,GUO Bin 1,2 &SHEN Daleng 1,2 1.Institute of Genetics,State Key Laboratory of Genetic Engineering,School of Life Science,Fudan University,Shanghai 200433,China 2.Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science, School of Life Science,Fudan University,Shanghai 200433,China | 2006 | Science China(Life Sciences)2006，49，5： | 4 |
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