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| 1 | 8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin显示文摘AIM:To evaluate whether 8-bromo-7-methoxychrysin(BrMC),a synthetic analogue of chrysin,inhibits the properties of cancer stem cells derived from the human liver cancer MHCC97 cell line and to determine the potential mechanisms.METHODS:CD133+cells were sorted from the MHCC97 cell line by magnetic activated cell sorting,and amplified in stem cell-conditioned medium to obtain the enriched CD133+sphere forming cells(SFCs).The stem cell properties of CD133+SFCs were validated by the tumorsphere formation assay in vitro and the xenograft nude mouse model in vivo,and termed liver cancer stem cells(LCSCs).The effects of BrMC on LCSCs in vitro were evaluated by MTT assay,tumorsphere formation assay and transwell chamber assay.The effects of BrMC on LCSCs in vivo were determined using a primary and secondary xenograft model in Balb/c-nu mice.Expressions of the stem cell markers,epithelialmesenchymal transition(EMT)markers andβ-catenin protein were analyzed by western blotting or immunohistochemical analysis.RESULTS:CD133+SFCs exhibited stem-like cell properties of tumorsphere formation and tumorigenesis capacity in contrast to the parental MHCC97 cells.We found that BrMC preferentially inhibited proliferation and self-renewal of LCSCs(P<0.05).Furthermore,BrMC significantly suppressed EMT and invasion of LCSCs.Moreover,BrMC could efficaciously eliminate LCSCs in vivo.Interestingly,we showed that BrMC decreased the expression ofβ-catenin in LCSCs.Silencing ofβ-catenin by small interfering RNA could synergize the inhibition of self-renewal of LCSCs induced by BrMC,while Wnt3a treatment antagonized the inhibitory effects of BrMC.CONCLUSION:BrMC can inhibit the functions and characteristics of LCSCs derived from the liver cancer MHCC97 cell line through downregulation ofβ-catenin expression. | Mei-Fang Quan Li-Hong Xiao Zhi-Hong Liu Hui Guo Kai-Qun Ren Fei Liu Jian-Guo Cao Xi-Yun Deng | 2013 | World Journal of Gastroenterology2013，19，43： | 22 |
| 2 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 3 | Experimental investigations on the heat transfer characteristics of micro heat pipe array applied to flat plate solar collector显示文摘This paper introduces a novel flat plate solar collector(FPC) using micro heat pipe array(MHPA) as a key element.To analyze the thermal transfer behavior of flat plate solar collector with micro heat pipe array(MHPA-FPC),an indoor experiment for thermal transfer characteristic of MHPA applied to FPC was conducted by using an electrical heating film to simulate the solar radiation.Different cooling water flow rates,cooling water temperatures,slopes,and contact thermal resistances between the condenser of MHPA and the heat exchanger were tested at different heating powers.The experimental results indicate that MHPA-FPC exhibits the enhanced heat transfer capability with increased cooling water flow rate and temperature.Total thermal resistance has a maximum decline of approximately 10% when the flow rate increases from 180 to 360 L h 1 and 38% when the cooling water temperature increases from 20℃ to 40℃.When the inclination angle of MHPA-FPC exceeds 30°,the slope change has a negligible effect on the heat transfer performance of MHPA-FPC.In addition,contact thermal resistance significantly affects the heat transfer capability of MHPA-FPC.The total thermal resistances lowers to nearly half of the original level when contact material between the condenser of MHPA and the heat exchanger changes from conductive silicone to conductive grease.These results could provide useful information for the optimal design and operation of MHPA-FPC. | DENG YueChao QUAN ZhenHua ZHAO YaoHua WANG LinCheng | 2013 | Science China(Technological Sciences)2013，56，5： | 17 |
| 4 | Impact of dissolved organic matter on the photolysis of the ionizable antibiotic norfloxacin显示文摘Norfloxacin(NOR), an ionizable antibiotic frequently used in the aquaculture industry, has aroused public concern due to its persistence, bacterial resistance, and environmental ubiquity.Therefore, we investigated the photolysis of different species of NOR and the impact of a ubiquitous component of natural water — dissolved organic matter(DOM), which has a special photochemical activity and normally acts as a sensitizer or inhibiter in the photolysis of diverse organics; furthermore, scavenging experiments combined with electron paramagnetic resonance(EPR) were performed to evaluate the transformation of NOR in water. The results demonstated that NOR underwent direct photolysis and self-sensitized photolysis via hydroxyl radical(U OH) and singlet oxygen(1O2) based on the scavenging experiments. In addition, DOM was found to influence the photolysis of different NOR species, and its impact was related to the concentration of DOM and type of NOR species. Photolysis of cationic NOR was photosensitized by DOM at low concentration, while zwitterionic and anionic NOR were photoinhibited by DOM, where quenching of U OH predominated according to EPR experiments, accompanied by possible participation of excited triplet-state NOR and1O2. Photo-intermediate identification of different NOR species in solutions with/without DOM indicated that NOR underwent different photodegradation pathways including dechlorination, cleavage of the piperazine side chain and photooxidation, and DOM had little impact on the distribution but influenced the concentration evolution of photolysis intermediates. The results implied that for accurate ecological risk assessment of emerging ionizable pollutants, the impact of DOM on the environmental photochemical behavior of all dissociated species should not be ignored. | Chen Liang Huimin Zhao Minjie Deng Xie Quan Shuo Chen Hua Wang | 2015 | Journal of Environmental Sciences2015，27，1： | 11 |
| 5 | Development of a Drilling and Coring Test-bed for Lunar Subsurface Exploration and Preliminary Experiments显示文摘Drill sampling has been widely employed as an effective way to acquire deep samples in extraterrestrial exploration. A novel sampling method, namely, flexible-tube coring, was adopted for the Chang'e mission to acquire drilling cores without damaging stratification information. Since the extraterrestrial environment is uncertain and different from the terrestrial environment, automated drill sampling missions are at risk of failure. The principles of drilling and coring for the lunar subsurface should be fully tested and verified on earth before launch. This paper proposes a test-bed for conducting the aforementioned experiments on earth. The test-bed comprises a rotary-percussive drilling mechanism, penetrating mechanism, drilling medium container, and signal acquisition and control system. For granular soil, coring experiments indicate that the sampling method has a high coring rate greater than 80%. For hard rock, drilling experiments indicate that the percussive frequency greatly affects the drilling efficiency. A multi-layered simulant composed of granular soil and hard rock is built to test the adaptability of drilling and coring. To tackle complex drilling media, an intelligent drilling strategy based on online recognition is proposed to improve the adaptability of the sampling drill. The primary features of this research are the proposal of a scheme for drilling and coring a test-bed for validation on earth and the execution of drilling experiments in complex media. | SHI Xiaomeng DENG Zongquan QUAN Qiquan TANG Dewei HOU Xuyan JIANG Shengyuan | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 10 |
| 6 | Drilling Power Consumption and Soil Conveying Volume Performances of Lunar Sampling Auger显示文摘The sampling auger used in lunar sampling and return mission is to transmit power and convey soil, and its performance is the key factor of the whole mission. However, there is currently a lack of the optimization research on soil conveying volume and power consumption models in auger structure design. To provide the drilled object, the simulation lunar soil, whose physical and mechanical property is the same as the real soil, is made by reducing soil void ratio. The models are formulated to analyze the influence of auger structure parameters on power consumption and soil conveying volume. To obtain the optimized structure parameters of auger, the multi-objective optimization functions of the maximum soil conveying volume and minimum power consumption are developed. To verify the correctness of the models, the performances of different augers drilling simulation soil are tested. The test results demonstrate that the power consumption of optimized auger is the lowest both in theory and test, and the experimental results of soil conveying volume are in agreement with theoretical analysis. Consequently, a new method for designing a lunar sampling auger is proposed which includes the models of soil conveying volume and transportation power consumption, the optimization of structure parameters and the comparison tests. This method provides a reference for sampling auger designing of the Chinese Lunar Sample Mission. | TIAN Ye TANG Dewei DENG Zongquan JIANG Shengyuan QUAN Qiquan | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 9 |
| 7 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 8 | Single-cell RNA sequencing data suggest a role for angiotensin-converting enzyme 2 in kidney impairment in patients infected with 2019-novel coronavirus显示文摘The World Health Organization has recently declared the 2019-novel coronavirus(2019-nCoV)a global public health emergency.Huang et al[1]reported acute kidney injury(AKI)in 7%of the 41 patients infected with 2019-nCoV,this value was even higher(up to 31%)among intensive-care patients.Furthermore,Li et al[2]reported that plasma creatinine levels increased in 11 of 59 patients with 2019-nCoV infection,suggesting that kidney function was probably impaired when the disease progressed.Guan et al[3]reported that plasma creatinine level increased in 4.3%of severely diseased patients.2019-nCoV is a highly contagious pathogen that predominantly causes pneumonic symptoms.Although respiratory failure has been associated with the highest mortality,the lung was not the only organ involved.Hoffmann et al[4]reported that 2019-nCoV and severe acute respiratory syndrome-associated coronavirus(SARS-CoV)share a common receptor angiotensin-converting enzyme 2(ACE2)that is required to enter target cells,and cellular protease transmembrane protease serine 2(TMPRSS2)can cleave and activate the spike protein of 2019-nCoV for membrane fusion.We investigated whether ACE2 and TMPRSS2 were expressed in kidney cells using precisiontechnology single-cell RNA sequencing. | Yi-Yao Deng Ying Zheng Guang-Yan Cai Xiang-Mei Chen Quan Hong | 2020 | Chinese Medical Journal2020，，9： | 7 |
| 9 | Drilling load modeling and validation based on the filling rate of auger flute in planetary sampling显示文摘Some type of penetration into a subsurface is required in planetary sampling. Drilling and coring, due to its efficient penetrating and cuttings removal characteristics, has been widely applied in previous sampling missions. Given the complicated mechanical properties of a planetary regolith, suitable drilling parameters should be matched with different drilling formations properly.Otherwise, drilling faults caused by overloads could easily happen. Hence, it is necessary to establish a drilling load model, which is able to reveal the relationships among drilling loads, an auger's structural parameters, soil's mechanical properties, and relevant drilling parameters. A concept for the filling rate of auger flute(FRAF) is proposed to describe drilling conditions. If the FRAF index under one group of drilling parameters is less than 1, this means that the auger flute currently removes cuttings smoothly. Otherwise, the auger will be choked with compressed cuttings. In drilling operations, the drilling loads on the auger mainly come from the conveyance action, while the drilling loads on the drill bit primarily come from the cutting action. Experiments in one typical lunar regolith simulant indicate that the estimated drilling loads based on the FRAF coincide with the test results quite well. Based on this drilling load model, drilling parameters have been optimized. | Quan Qiquan Tang Junyue Yuan Fengpei Jiang Shengyuan Deng Zongquan | 2017 | Chinese Journal of Aeronautics2017，30，1： | 7 |
| 10 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 11 | AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs显示文摘AFF1 and AFF4 belong to the AFF(AF4/FMR2) family of proteins, which function as scaffolding proteins linking two different transcription elongation factors, positive elongation factor b(P-TEFb) and ELL1/2, in super elongation complexes(SECs). Both AFF1 and AFF4 regulate gene transcription through elongation and chromatin remodeling. However, their function in the osteogenic differentiation of mesenchymal stem cells(MSCs) is unknown. In this study, we show that small interfering RNA(si RNA)-mediated depletion of AFF1 in human MSCs leads to increased alkaline phosphatase(ALP) activity, enhanced mineralization and upregulated expression of osteogenic-related genes. On the contrary, depletion of AFF4 significantly inhibits the osteogenic potential of MSCs. In addition, we confirm that overexpression of AFF1 and AFF4 differentially affects osteogenic differentiation in vitro and MSC-mediated bone formation in vivo.Mechanistically, we find that AFF1 regulates the expression of DKK1 via binding to its promoter region.Depletion of DKK1 in HA-AFF1-overexpressing MSCs abrogates the impairment of osteogenic differentiation. Moreover, we detect that AFF4 is enriched in the promoter region of ID1. AFF4 knockdown blunts the BRE luciferase activity, SP7 expression and ALP activity induced by BMP2 treatment. In conclusion, our data indicate that AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs. | Chen-chen Zhou Qiu-chan Xiong Xin-xing Zhu Wen Du Peng Deng Xiao-bing Li Yi-zhou Jiang Shu-juan Zou Cun-yu Wang Quan Yuan | 2017 | Bone Research2017，5，3： | 6 |
| 12 | Simple β-lactones are potent irreversible antagonists for strigolactone receptors显示文摘 | Haibo Xian Ruifeng Yao Tianfei Quan Fei Wang Li Chen Xiaoxi DU Wenhao Zhang Haiteng Deng Daoxin Xie Tuoping Luo | 2017 | Cell Research2017，27，12： | 5 |
| 13 | Phase field crystal simulation of grain boundary movement and dislocation reaction显示文摘阶段地水晶(陆军) 模型被用来模仿 premelting 脱臼运动对称当系统温度在时,在紧张行动下面倾斜谷物边界(STGB ) 远非,到融化的融化的点和结束分别地指。结果证明当 premelting 温度被接近到,本地 premelting 发生包围脱臼从在温度下面。STGB 的 premelting 脱臼能在紧张行动下面滑行,并且 premelting 区域是为脱臼滑行的一个同伴。STGB 腐烂的过程以二个高温度条件是很类似的。当 premelting 介绍,它减少为脱臼的滑行抵抗并且导致脱臼的一个更快的运动,并且也在 STGB 的腐烂过程期间引起系统的更多的精力减小。尽管有把紧张用于这些, premelting 在 STGB 的整个腐烂过程取样, premelting 脱臼区域显然不发展并且延长。这显示外部紧张行动不在高温度支持 premelting,并且不能导致更多的 premelting 脱臼,它能在脱臼展览附近被欠到 premelting 阶段像液体的性质并且到容易滑行并且放松紧张精力的 premelting 脱臼;这与实验和分子的动力学的结果一致。 | Ying-Jun GAO Qian-Qian DENG Si-Long QUAN Wen-Quan ZHOU Chuang-Gao HUANG | 2014 | Frontiers of Materials Science2014，8，2： | 5 |
| 14 | Impact of diabetes on the prognosis of hip fracture: a cohort study in the Chinese population显示文摘 | WANG Hong LV Yan-wei LAN Ling ZHANG Quan CHEN Hai-ling ZHANG Guo-ying DENG Li-li LI Ju-fen | 2013 | Chinese Medical Journal2013，，5： | 4 |
| 15 | Differences and similarities between extremely severe oligozoospermia and cryptozoospermia in intracytoplasmic sperm injection显示文摘有极其严重的 oligozoospermia (ESO ) 和 cryptozoospermia (公司) 的病人作为不孕治疗用 intracytoplasmic 精子注射(ICSI ) 是合适的。然而,某 andrologists 被糊涂在诊所区分 ESO 和公司诊断。这研究第一次被设计评估并且把病人与 ESO 和公司作比较决定这些是否是有用临床的区别。在我们的中心的 270 个不肥沃的人的一个总数作为组 nonobstruction 精子缺乏被分类进四个组(NOA, n = 44 ) ,组 ESO (n = 78 ) ,组公司(n = 40 ) ,并且组阻塞精子缺乏(OA, n = 108 ) 。双边的睾丸的体积的比较,刺激荷尔蒙(FSH ) 和 inhibin B 的滤泡的水平在四个组被获得。当夫妇们执行了 ICSI 时,然后,授精率,劈开率,和优秀胚胎率的比较被获得。当组 OA 对 NOA, OA 对 ESO,和 OA 对公司是重要差别时,在组 ESO 和公司的所有索引(双边的睾丸, FSH 的水平和 inhibin B 的体积) 不是差别(P <0.05 ) 。当组 OA 对 ESO, OA 对公司是重要差别时,授精的率不是在组 ESO 和公司的差别(P <0.05 ) 。因此,在有公司和 ESO 的病人的 spermatogenic 功能类似、比 NOA 好却比 OA 更坏。然而,用阴囊的活体检视评估他们的精子发生将是有用的,在临床的实践的特别伴随的精子缺乏。 | Yong-Tong Zhu Chen Luo Yun Li Hong Li Song Quan Yong-Jian Deng Yu Yang Yong-Hua Hu Wan-Long Tan Qing-Jun Chu | 2016 | Asian Journal of Andrology2016，18，6： | 4 |
| 16 | Competing endogenous RNA screening based on long noncoding RNA-messenger RNA co-expression profile in Hepatitis B virus-associated hepatocarcinogenesis显示文摘OBJECTIVE: To profile the liver cancer specific long noncoding RNAs(lnc RNAs) and competing endogenous RNA(ce RNA) networks of Hepatitis B virus(HBV)-associated hepatocarcinogensis(HCG) and to examine the effect of compound K on the expression of identified ce RNA networks.METHODS: Based on lnc RNA and messenger RNA(m RNA) microarray data of HBV-associated liver cancer, the current study profiles the cancer specific lnc RNAs and ce RNA networks of HBV-associated HCG through comprehensive application of Reg RNA 2, mi RTar Base and Pearson correlation coefficient analysis. Compound K-treated liver cancer cells were harvested for analysis of transcriptional levels of both enoyl-Co A hydratase and 3-hydroxyacyl Co A dehydrogenase(EHHADH)-AS1 and ENTPD5.RESULTS: The results revealed that 11 Encyclopedia of DNA Elements annotated lnc RNAs were differentially expressed in the process of HBV-associated HCG. Among these lnc RNAs, 95 potential ce RNA networks with highly positively correlated expression profiles between the interacting lnc RNAs and m RNAs(Pearson correlation coefficient ≥ 0.7) were constructed. Of note, two HBV-associated ce RNA networks, EHHADH-AS1-hsa-mi R-4459-ectonucleoside triphosphate diphosphohydrolase 5 and LINC01018-hsa-mi RNA-574-5p-glucose-6-phosphatase catalytic subunit, with Pearson correlation coefficient ≥ 0.9, may play a critical role in hepatocellular carcinoma development, which was supported by experimental evidence. Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including Hep G3 B, Huh-7 and plc/prf/5 cells.CONCLUSION: Comprehensive application of co-expression network analysis and prediction of RNA interaction may be a feasible strategy to unravel the potential ce RNA networks involved in the process of human diseases. | Wen Quan Yang Yao Chen Xianhua Pan Xiaodong Han Qi Wang Dong Deng Youcai Li Xiaohui Yan Jun Zhou Jihong | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 3 |
| 17 | Multi-state autonomous drilling for lunar exploration显示文摘Due to the lack of information of subsurface lunar regolith stratification which varies along depth, the drilling device may encounter lunar soil and lunar rock randomly in the drilling process. To meet the load safety requirements of unmanned sampling mission under limited orbital resources, the control strategy of autonomous drilling should adapt to the indeterminable lunar environments. Based on the analysis of two types of typical drilling media(i.e., lunar soil and lunar rock), this paper proposes a multi-state control strategy for autonomous lunar drilling. To represent the working circumstances in the lunar subsurface and reduce the complexity of the control algorithm, lunar drilling process was categorized into three drilling states: the interface detection, initiation of drilling parameters for recognition and drilling medium recognition. Support vector machine(SVM) and continuous wavelet transform were employed for the online recognition of drilling media and interface, respectively. Finite state machine was utilized to control the transition among different drilling states. To verify the effectiveness of the multi-state control strategy, drilling experiments were implemented with multi-layered drilling media constructed by lunar soil simulant and lunar rock simulant. The results reveal that the multi-state control method is capable of detecting drilling state variation and adjusting drilling parameters timely under vibration interferences.The multi-state control method provides a feasible reference for the control of extraterrestrial autonomous drilling. | Chen Chongbin Quan Qiquan Shi Xiaomeng Deng Zongquan Tang Dewei Jiang Shengyuan | 2016 | Chinese Journal of Aeronautics2016，29，5： | 3 |
| 18 | Synthesis of polyacrylonitrile-block-polydimethylsiloxane-block-polyacrylonitrile triblock copolymers via RAFT polymerization显示文摘A new A-B-A type of block copolymers,polyacrylonitrile-block-polydimethylsiloxane-block-polyacrylonitrile(PAN-b-PDMSb-PAN),which comprises two polymer blocks of different polarities and compatibilities,were synthesized for the first time via reversible addition-fragmentation chain transfer polymerization.Reaction kinetics was investigated.PAN-b-PDMS-b-PAN films were prepared by spin-coating on glass chips.Significant order on the film surface morphologies was observed. | Zheng Yue Deng Xu Wang Jing Quan Liu Jie Zhang Sheng Yu Feng | 2012 | Chinese Chemical Letters2012，23，8： | 2 |
| 19 | Recent progress on multifunctional electromagnetic interference shielding polymer composites显示文摘The explosive development of electronic devices and wireless communication technology gives rise to the issue of electromagnetic pollution,known as electromagnetic interference(EMI).The accumulation of undesirable electromagnetic radiation in space disturbs the normal function of unshielded electronic appliances and poses seriously threat to human health.Thus,the development of EMI shielding materials have emerged to solve the grim problem.Considering the complex application contexts,EMI shielding materials have evolved from traditional single-function to multi-functions to meet the ever-increasing application requirements in recent few years.This paper provides detailed insight into the current re-search status and future challenges in the advancement of polymer-based EMI shielding materials with various functions.First,the basic theory of EMI shielding,factors influencing results and the dominating characterization technologies for EMI shielding properties are summarized.Then,the comprehensive descriptions of the seven types of multifunctional EMI shields are provided with respect to their structures,fabrication methods and specific functions.Meanwhile,the corresponding critical scientific and technical issues are proposed.Based on our comprehensive analysis,the main challenges in the development of multifunctional EMI shielding materials are presented.This review aims to provide some guidance and inspire more efforts toward functional EMI shielding material research to satisfy the growing requirements for next-generation electronic systems. | Ke Tian Danrong Hu Quan Wei Qiang Fu Hua Deng | 2023 | Journal of Materials Science & Technology2023，，3： | 2 |
| 20 | Impact of human leukocyte antigen mismatching on outcomes of liver transplantation:A meta-analysis显示文摘AIM:To assess the effect of human leukocyte antigen(HLA) mismatching on liver graft outcome and acute rejection from a meta-analysis of available cohort studies.METHODS:Articles in PubMed/MEDLINE,EMBASE and the Cochrane database from January 1970 to June 2009,including non-English literature identified in these databases,were searched.Only studies comparing HLA or sub-phenotype matching with mismatching were extracted.The percentage of graft survival was extracted by 'Engauge Digitizer' from survival curves if the raw data were not displayed.A meta-analysis was performed when at least 3 studies provided data.RESULTS:Sixteen studies met the inclusion criteria.A lower number of HLA mismatches(0-2 vs 3-6) did reduce the incidence of acute rejection(relative risk:0.77,P = 0.03).The degree of HLA mismatching(0-2 vs 3-6) had no significant effect on 1-year [hazard ratio(HR):1.04,P = 0.68] and 5-year(HR:1.09,P = 0.38) graft survival.In sub-phenotype analysis,the degree of HLA-A,B and DR mismatching(0 vs 1-2) had no significant effect on 1-year and 5-year graft survival,either.The HRs and P-values were 0.95,0.71(HLA-A,1-year);1.06,0.60(HLA-A,5-year);0.77,0.16(HLA-B,1-year);1.07,0.56(HLA-DR,1-year);1.18,0.23(HLADR,5-year),respectively.CONCLUSION:The results of this systematic review imply that good HLA compatibility can reduce the incidence of acute rejection in spite of having no influence on graft outcomes.To obtain a short recovery time and minimize rejection post transplantation,HLA matching studies should be considered before the operation. | Xiang Lan Ming-Man Zhang Cong-Lun Pu Chun-Bao Guo Quan Kang Ying-Chun Li Xiao-Ke Dai Yu-Hua Deng Qiang Xiong Zhi-Mei Ren | 2010 | World Journal of Gastroenterology2010，16，27： | 2 |
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