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| 1 | An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice显示文摘 | Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha | 2017 | Cell Research2017，27，11： | 2 |
| 2 | The Protein Arginine Methylase 5(PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage显示文摘Plant root stem cells and their surrounding microenvironment,namely the stem cell niche,are hypersensitive to DNA damage.However,the molecular mechanisms that help maintain the genome stability of root stem cells remain elusive.Here we show that the root stem cells in the skbl(Shk1 kinase binding protein 1) mutant undergoes DNA damage-induced cell death,which is enhanced when combined with a lesion of the Ataxia-telangiectasia mutated(ATM) or the ATM/RAD3-related(ATR) genes,suggesting that the SKBI plays a synergistically effect with ATM and ATR in DNA damage pathway.We also provide evidence that SKBI is required for the maintenance of quiescent center(QC),a root stem cell niche,under DNA damage treatments.Furthermore,we report decreased and ectopic expression of SHORTROOT(SHR) in response to DNA damage in the skbl root tips,while the expression of SCARECROW(SCR) remains unaffected.Our results uncover a new mechanism of plant root stem cell maintenance under DNA damage conditions that requires SKB1. | Qiuling Li Yan Zhao Minghui Yue Yongbiao Xue Shilai Bao | 2016 | Journal of Genetics and Genomics2016，43，4： | 1 |
| 3 | Stimuli-responsive gel-micelles with flexible modulation of drug release for maximized antitumor efficacy显示文摘设计的刺激应答的药交货设备由于他们的最大化的治疗学的功效为疾病处理在生物应用保持广阔诺言。在这研究,一篇小说,稳定地, cross-linked ,和pH敏感的可被细菌破坏的 gel-micelle 与 amphiphilic 被构造 trimethylene dipiperidine甲基丙烯结合酐玻尿的 acid-stearylamine ( TMDP-MA-HA-SA , TMHS )改善与 paclitaxel ( PTX )的灵活细胞内部的交货指向肿瘤 .The cross-linked methacrylate 契约显著地改进了 TMHS gel-micelle 的 biostability (~ 200 nm )在上在生理的条件下面交叉结合得非,当玻尿的酸玩时cross-linked 的渐渐的降级玻尿的酸壳被集中的玻尿酸酵素触发。同时,在酸的条件下面(pH < 6.5 ) , pH 敏感的 TMDP 一半的第三级的胺是 protonated 并且从而 solubilized gel-micellar 核心部分。结果的被触发 pH 的内部核心的空格很快面对主要降级了的多重 cytosolic 酶推动了 PTX 版本仍然保持恐水病 stearylamine 核心。在期间在里面 vitro cytotoxicity 试金,装载 PTX 的 TMHS 胶化微粒(CLTMHSPTX ) 与 1.42 g/mL (PTX 集中) 的 IC 50 对人的 hepatocellular 癌 HepG2 房间揭示了 anticancer 功效,比另外的组显著地低。在平行,在里面 CL TMHS 对 BALB/c 异种皮移植肿瘤动物模型的 PTX 胶化微粒表明了 72.06% 的更大的肿瘤生长抑制能力,与在安全集中的另外的处理组相比。因而, cross-linked 和刺激应答的 CL TMHS PTX 胶化微粒抓住为有最大化的 antitumor 功效的恐水病的 anticancer 药的细胞内部的交货的灵活调整的一个大潜力。 | Djamila Aouameur Hao Cheng Yaw Opoku-Damoah Bo Sun Qiuling Dong Yue Han Jianping Zhou Yang Ding | 2018 | Nano Research2018，11，8： | 1 |
| 4 | A chromosome-level genome assembly for Dracaena cochinchinensis reveals the molecular basis of its longevity and formation of dragon’s blood显示文摘Dracaena,a remarkably long-lived and slowly maturing species of plant,is world famous for its ability to produce dragon’s blood,a precious traditional medicine used by different cultures since ancient times.However,there is no detailed and high-quality genome available for this species at present;thus,the molecular mechanisms that underlie its important traits are largely unknown.These factors seriously limit the protection and regeneration of this rare and endangered plant resource.Here,we sequenced and assembled the genome of Dracaena cochinchinensis at the chromosome level.The D.cochinchinensis genome covers 1.21 Gb with a scaffold N50 of 50.06 Mb and encodes 31619 predicted protein-coding genes.Analysis showed that D.cochinchinensis has undergone two whole-genome duplications and two bursts of long terminal repeat insertions.The expansion of two gene classes,cis-zeatin O-glucosyltransferase and small auxin upregulated RNA,were found to account for its longevity and slow growth.Two transcription factors(bHLH and MYB)were found to be core regulators of the flavonoid biosynthesis pathway,and reactive oxygen species were identified as the specific signaling molecules responsible for the injuryinduced formation of dragon’s blood.Our study provides high-quality genomic information relating to D.cochinchinensis and significant insight into the molecular mechanisms responsible for its longevity and formation of dragon’s blood.These findings will facilitate resource protection and sustainable utilization of Dracaena. | Yanhong Xu Kaijian Zhang Zhonglian Zhang Yang Liu Feifei Lv Peiwen Sun Shixi Gao Qiuling Wang Cuicui Yu Jiemei Jiang Chuangjun Li Meifang Song Zhihui Gao Chun Sui Haitao Li Yue Jin Xinwei Guo Jianhe Wei | 2022 | Plant Communications2022，3，6： | 0 |
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