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| 1 | Neuroprotective effect of penehyclidine hydrochloride on focal cerebral ischemia-reperfusion injury显示文摘Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochloride in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of Bcl-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect. | Cuicui Yu Junke Wang | 2013 | Neural Regeneration Research2013，8，7： | 12 |
| 2 | Spatial pattern of grassland aboveground biomass and its environmental controls in the Eurasian steppe显示文摘Vegetation biomass is an important component of terrestrial ecosystem carbon stocks. Grasslands are one of the most widespread biomes worldwideplaying an important role in global carbon cycling. Thereforestudying spatial patterns of biomass and their correlations to environment in grasslands is fundamental to quantifying terrestrial carbon budgets. The Eurasian steppean important part of global grasslandsis the largest and relatively well preserved grassland in the world. In this studywe analyzed the spatial pattern of aboveground biomass(AGB)and correlations of AGB to its environment in the Eurasian steppe by meta-analysis. AGB data used in this study were derived from the harvesting method and were obtained from three data sources(literatureglobal NPP database at the Oak Ridge National Laboratory Distributed Active Archive Center(ORNL)some data provided by other researchers). Our results demonstrated that:(1) as for the Eurasian steppe overallthe spatial variation in AGB exhibited significant horizontal and vertical zonality. In detailAGB showed an inverted parabola curve with the latitude and with the elevationwhile a parabola curve with the longitude. In additionthe spatial pattern of AGB had marked horizontal zonality in the Black Sea-Kazakhstan steppe subregion and the Mongolian Plateau steppe subregionwhile horizontal and vertical zonality in the Tibetan Plateau alpine steppe subregion.(2) Of the examined environmental variablesthe spatial variation of AGB was related to mean annual precipitation(MAP)mean annual temperature(MAT)mean annual solar radiation(MAR)soil Gravel contentsoil p H and soil organic content(SOC) at the depth of 0–30 cm. NeverthelessMAP dominated spatial patterns of AGB in the Eurasian steppe and its three subregions.(3) A Gaussian function was found between AGB and MAP in the Eurasian steppe overallwhich was primarily determined by unique patterns of grasslands and environment in the Tibetan Plateau. AGB was significantly positively related to MAP in the Black Sea-Kazakhstan steppe subregion(elevation < 3000 m)the Mongolian Plateau steppe subregion(elevation < 3000 m) and the surface(elevation ≥ 4800 m) of the Tibetan Plateau. Neverthelessthe spatial variation in AGB exhibited a Gaussian function curve with the increasing MAP in the east and southeast margins(elevation < 4800 m) of the Tibetan Plateau. This study provided more knowledge of spatial patterns of AGB and their environmental controls in grasslands than previous studies only conducted in local regions like the Inner Mongolian temperate grasslandthe Tibetan Plateau alpine grasslandetc. | JIAO Cuicui YU Guirui HE Nianpeng MA Anna GE Jianping HU Zhongmin | 2017 | Journal of Geographical Sciences2017，27，1： | 7 |
| 3 | Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration显示文摘Macrophages play an important role in material-related immune responses and bone formation,but the functionality of macrophage-derived extracellular vesicles(EVs)in material-mediated bone regeneration is still unclear.Here,we evaluated intracellular communication through small extracellular vesicles(sEVs)and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen(IMC).After implantation in the bone defect area,IMC generated more neobone and recruited more mesenchymal stem cells(MSCs)than did extrafibrillarly mineralized collagen(EMC).More CD63+CD90+and CD63+CD163+cells were detected in the defect area in the IMC group than in the EMC group.To determine the functional roles of sEVs,extracellular vesicles from macrophages cultured on different mineralized collagen were isolated,and they showed no morphological differences.However,macrophage-derived sEVs in the IMC group showed an enhanced Young’s modulus and exerted beneficial effects on the osteogenic differentiation of bone marrow MSCs by increasing the expression of the osteoblastic differentiation markers BMP2,BGLAP,COL1,and OSX and calcium nodule formation.Mechanistically,sEVs from IMC-treated macrophages facilitated MSC osteogenesis through the BMP2/Smad5 pathway,and blocking sEV secretion with GW4869 significantly impaired MSC proliferative,immunomodulative and osteogenic potential.Taken together,these findings show that macrophage-derived sEVs may serve as an emerging functional tool in biomaterial-mediated endogenous bone regeneration. | Anqi Liu Shanshan Jin Cuicui Fu Shengji Cui Ting Zhang Lisha Zhu Yu Wang Steve G.F.Shen Nan Jiang Yan Liu | 2020 | International Journal of Oral Science2020，12，4： | 5 |
| 4 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 5 | All-optical computing based on convolutional neural networks显示文摘The rapid development of information technology has fueled an ever-increasing demand for ultrafast and ultralow-en-ergy-consumption computing.Existing computing instruments are pre-dominantly electronic processors,which use elec-trons as information carriers and possess von Neumann architecture featured by physical separation of storage and pro-cessing.The scaling of computing speed is limited not only by data transfer between memory and processing units,but also by RC delay associated with integrated circuits.Moreover,excessive heating due to Ohmic losses is becoming a severe bottleneck for both speed and power consumption scaling.Using photons as information carriers is a promising alternative.Owing to the weak third-order optical nonlinearity of conventional materials,building integrated photonic com-puting chips under traditional von Neumann architecture has been a challenge.Here,we report a new all-optical comput-ing framework to realize ultrafast and ultralow-energy-consumption all-optical computing based on convolutional neural networks.The device is constructed from cascaded silicon Y-shaped waveguides with side-coupled silicon waveguide segments which we termed“weight modulators”to enable complete phase and amplitude control in each waveguide branch.The generic device concept can be used for equation solving,multifunctional logic operations as well as many other mathematical operations.Multiple computing functions including transcendental equation solvers,multifarious logic gate operators,and half-adders were experimentally demonstrated to validate the all-optical computing performances.The time-of-flight of light through the network structure corresponds to an ultrafast computing time of the order of several picoseconds with an ultralow energy consumption of dozens of femtojoules per bit.Our approach can be further expan-ded to fulfill other complex computing tasks based on non-von Neumann architectures and thus paves a new way for on-chip all-optical computing. | Kun Liao Ye Chen Zhongcheng Yu Xiaoyong Hu Xingyuan Wang Cuicui Lu Hongtao Lin Qingyang Du Juejun Hu Qihuang Gong | 2021 | Opto-Electronic Advances2021，4，11： | 3 |
| 6 | Determination of triglycerides in human serum by near-infrared diffuse reflectance spectroscopy using silver mirror as a substrate显示文摘Near infrared diffuse reflectance spectroscopy(NIRDRS) has gained wide attention due to its convenience for rapid quantitative analysis of complex samples. A method for rapid analysis of triglycerides in human serum using NIRDRS with silver mirror as the substrate is developed. Due to the even and high reflectance of the silver mirror, the spectral response is enhanced and the background interference is reduced.Furthermore, both linear and nonlinear modeling strategies were investigated adopting the partial least squares(PLS) and least squares support vector regression(LS-SVR), continuous wavelet transform(CWT)was used for spectral preprocessing, and variable selection was tried using Monte Carlo uninformative variable elimination(MC-UVE), randomization test(RT) and competitive adaptive reweighted sampling(CARS) for optimization the models. The results show that the determination coefficient(R) between the predicted and reference concentration is 0.9624 and the root mean squared error of prediction(RMSEP) is 0.21. The maximum deviation of the prediction results is as low as 0.473 mmol/L. The proposed method may provide an alternative method for routine analysis of serum triglycerides in clinical applications. | Shuyu Wang Jin Zhang Cuicui Wang Xiaoming Yu Wensheng Cai Xueguang Shao | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 7 | Pretreatment of wastewater from acrylonitrile–butadiene–styrene (ABS) resin manufacturing by microelectrolysis显示文摘 | Bo Lai Yuexi Zhou Hongke Qin Changyong Wu Cuicui Pang Yu Lian Jixian Xu | 2011 | Chemical Engineering Journal2011，，： | 1 |
| 8 | Sequential solvent extraction for forms of antimony in five selected coals 显示文摘 | Qi Cuicui Liu Guijian Yu Kang | 2008 | The Journal Of Geology2008，116，2： | 1 |
| 9 | Analysis on impact factor ofShanxi province industrial low carbon[J]显示文摘 | YAO Yu(姚宇) HAN Cuicui(韩翠翠) | 2010 | 新西部2010，，20： | 1 |
| 10 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 11 | Pretreatment of wastewater from acrylonitrile–butadiene–styrene (ABS) resin manufacturing by microelectrolysis显示文摘 | Bo Lai Yuexi Zhou Hongke Qin Changyong Wu Cuicui Pang Yu Lian Jixian Xu | 2011 | Chemical Engineering Journal2011，，： | 1 |
| 12 | NIR-responsive Collagen-based Sponge Coated with Polydimethylsiloxane/Candle Soot for Oil-Water Separation显示文摘To fabricate an oil-water separation material that is rich in source,eco-friendly,and responsive,in this study,we successfully developed a collagen-based sponge for application to oil-water separation based on a green and facile strategy.In this design,widely-available collagen(COL)was used as the substrate:it was immersed in polydimethylsiloxane(PDMS)suspension with candle soot(CS)nanoparticles,followed by hot curing.The resultant sponge(CS/PDMS-COL)possessed good hydrophobicity with a water contact angle of 148.3°under a low PDMS concentration of 2%.The results from field emission scanning electron microscope,Fourier transform infrared spectrometer,X-ray photoelectron spectrometer,and X-ray diffractometry demonstrated the successful coating of CS and PDMS on the surface of COL substrate.The CS/PDMS-COL can adsorb eight oils,with the adsorption capacity for trichloromethane reaching 95 g/g.With benzene as the target adsorbent,the separation efficiency was maintained at no less than 95%even after recycling 20 times.CS/PDMS-COL was also used to separate oil-in-water emulsion.Moreover,the sponge killed bacteria effectively due to its excellent near-infrared photothermal responsiveness.This study provides new insight into the preparation of facile oil-water separation materials based on naturally occurring biomaterials effortlessly. | Min Zhang Chenchen Guo Yu Wang Yunlong Zhang Hui Wu Liulian Huang Yonghao Ni Cuicui Ding Lihui Chen | 2022 | Paper And Biomaterials2022，7，3： | 0 |
| 13 | A chromosome-level genome assembly for Dracaena cochinchinensis reveals the molecular basis of its longevity and formation of dragon’s blood显示文摘Dracaena,a remarkably long-lived and slowly maturing species of plant,is world famous for its ability to produce dragon’s blood,a precious traditional medicine used by different cultures since ancient times.However,there is no detailed and high-quality genome available for this species at present;thus,the molecular mechanisms that underlie its important traits are largely unknown.These factors seriously limit the protection and regeneration of this rare and endangered plant resource.Here,we sequenced and assembled the genome of Dracaena cochinchinensis at the chromosome level.The D.cochinchinensis genome covers 1.21 Gb with a scaffold N50 of 50.06 Mb and encodes 31619 predicted protein-coding genes.Analysis showed that D.cochinchinensis has undergone two whole-genome duplications and two bursts of long terminal repeat insertions.The expansion of two gene classes,cis-zeatin O-glucosyltransferase and small auxin upregulated RNA,were found to account for its longevity and slow growth.Two transcription factors(bHLH and MYB)were found to be core regulators of the flavonoid biosynthesis pathway,and reactive oxygen species were identified as the specific signaling molecules responsible for the injuryinduced formation of dragon’s blood.Our study provides high-quality genomic information relating to D.cochinchinensis and significant insight into the molecular mechanisms responsible for its longevity and formation of dragon’s blood.These findings will facilitate resource protection and sustainable utilization of Dracaena. | Yanhong Xu Kaijian Zhang Zhonglian Zhang Yang Liu Feifei Lv Peiwen Sun Shixi Gao Qiuling Wang Cuicui Yu Jiemei Jiang Chuangjun Li Meifang Song Zhihui Gao Chun Sui Haitao Li Yue Jin Xinwei Guo Jianhe Wei | 2022 | Plant Communications2022，3，6： | 0 |
| 14 | Emerging nanozymes for potentiating radiotherapy and radiation protection显示文摘While radiotherapy is a mainstay therapeutic modality for malignant tumor,the intrinsic tumor resistance to radiotherapy,as well as the concomitant radiation injury to adjacent healthy tissues,greatly limits the efficacy of cancer radiotherapy.As a result,the development of novel radioenhancers and radioprotectants is highly desired for clinical radiotherapy.In recent years,nanozymes have inspired ever-growing research interest because of their multi-enzyme activities and microenvironment-responsive feature.In view of the significant progress of nanozymes in radiation medicine,we,in this review,systematically illustrate the impressive progress of nanozymes for potentiating radiotherapy and radiation protection.First,the types of nanozymes used in tumor radiotherapy are briefly discussed.Subsequently,the main strategies of nanozymes to enhance the radiotherapy efficiency,including promoting the generation of reactive oxygen species(ROS),relieving hypoxia in tumor microenvironment and combining with other cancer therapeutic regimens,are summarized.Finally,the advances of typical nanozymes for preventing radiation-induced hematopoietic damage and gastrointestinal damage are highlighted. | Yu Chong Jiayu Ning Shengyi Min Jiaquan Ye Cuicui Ge | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 15 | Research Progress of circRNAs during Epithelial- Mesenchymal Transition of Hepatocellular Carcinoma显示文摘Hepatocellular carcinoma is prone to invasion and metastasis.It often receives a low diagnosis rate in the early stage but has an extremely high mortality rate.Epithelial-mesenchymal transformation(EMT)is a key factor in promoting tumor cell invasion and metastasis.Circular RNA(circRNA)is involved in regulating EMT in hepatocarcinoma cells through multiple pathways,thereby affecting the occurrence and progression of hepatocellular carcinoma.This article mainly reviews the research progress of circRNA related to EMT core transcription factors,circRNA that promotes EMT in liver cancer,and circRNA that inhibits EMT in liver cancer. | Yuqing Li Cuicui Ren Yu Cai Chang Tian Yuanyuan Jia Ge Wu | 2024 | Proceedings of Anticancer Research2024，8，2： | 0 |
| 16 | Assessment and Optimization Strategies of Campus Sound Environment显示文摘A good sound environment is essential in creating a harmonious and peaceful campus,improving students’learning outcomes,promoting physical and mental health,and creating a green and healthy campus.This study investigated the impact of new buildings on existing ones by optimizing the spacing between new buildings and the sound insulation structure of building enclosures.The results indicated that building 4 was affected by the noise from new building 1 and its surroundings,with a maximum outdoor daytime noise level reaching 69 dB,and the indoor background noise level in the least favorable classroom was 43.73 dB,less than 45 dB,which was within the acceptable range.It is recommended that the sound insulation design be improved in the planning of new teaching buildings.Besides,the surrounding traffic conditions should be improved,and the usage time of sports facilities should be scheduled appropriately to prevent the noise from sporting activities from affecting the classroom activities.The findings of this study provide valuable references for future architectural acoustics design and campus planning,contributing to the creation of peaceful and comfortable campus environments. | Cuicui Qin Qiliang Yu Wei Zhang | 2023 | Journal of World Architecture2023，7，6： | 0 |
| 17 | Analysis of the Architectural Design Talent Development Direction by Investigating the Employment Status of Architectural Design Graduates显示文摘Based on a comprehensive investigation of the employment status of architectural design graduates at a certain university,this paper analyzes the correctness of the talent development direction of architectural design in hopes of pro-viding a valuable reference for further teaching reform and strengthening school-enterprise collaboration.The research re-sults show that architectural design is the main choice of graduates,accounting for as high as 63%,and traditional architec-tural design skills continue to be in demand in the market.Employment in fields such as interior design,BIM design,and green architecture is also included.The distribution of job positions for graduates is mainly in the areas of scheme design assistants and construction drawing design,requiring software operation,communication,scheme design,and construction drawing skills.This paper also proposes talent development measures such as optimizing the curriculum,strengthening faculty construction,and deepening school-enterprise collaboration,in order to improve the quality of talent development and the competitiveness of graduates. | Cuicui Qin Lijuan Xie Qiliang Yu Guanhong Chen Binquan Zhang Yani Gao | 2023 | Journal of Architectural Research and Development2023，7，6： | 0 |
| 18 | Simulation Evaluation of Outdoor Noise Environment in Buildings显示文摘Green campus design has become an essential strategy to enhance campus life and learning.However,noise pol-lution remains a troubling aspect that impacts teaching and learning processes,even causing harm to the health of students and teachers.Therefore,acoustic environment quality design is crucial.This article focuses on the expansion project of a school campus in Shenzhen.We simulated and analyzed the outdoor noise environment separately for the proposed teach-ing building,as well as the existing buildings like the dining hall,teaching building,and laboratory building.The results showed that the proposed teaching building was mainly affected by surrounding noise,with the worst outdoor noise being in classrooms adjacent to the teaching building in the south and the basketball court at the west of the classroom,with maximum noise values reaching 73 dB and 66 dB,respectively.In the future,these rooms should be renovated to achieve an excellent indoor soundproof environment. | Cuicui Qin Qiliang Yu Wenyu Zou | 2023 | Journal of Architectural Research and Development2023，7，6： | 0 |
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