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| 1 | Plasma exchange-centered artificial liver support system in hepatitis B virus-related acute-onchronic liver failure:a nationwide prospective multicenter study in China显示文摘BACKGROUND:Plasma exchange(PE)-centered artificial liver support system reduced the high mortality rate of hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).But the data were diverse in different medical centers.The present prospective nationwide study was to evaluate the effects of PE on patients with HBV-ACLF at different stages.METHODS:From December 2009 to December 2011,we evaluated 250 patients at different stages of HBV-ACLF from 10 major medical centers in China.All the laboratory parameters were collected at admission,before and after PE.RESULTS:Among the 250 patients who underwent 661 rounds of PE,one-month survival rate was 61.6%; 141(56.4%) showed improvement after PE.Variables such as age(P=0.000),levels of total bilirubin(TB,P=0.000),direct bilirubin(P=0.000),total triglycerides(P=0.000),low-density lipoprotein(P=0.022),Na+(P=0.014),Cl–(P=0.038),creatinine(Cr,P=0.007),fibrinogen(P=0.000),prothrombin time(PT,P=0.000),white blood cell(P=0.000),platelet(P=0.003) and MELD(P=0.000) were significantly related to prognosis.Multivariate logistic regression analysis showed that age,disease stage,TB,Cr and PT levels were independent risk factors of mortality among HBV-ACLF patients.CONCLUSIONS:PE can improve the clinical outcome of patients with HBV-ACLF.Levels of TB,Cr and PT,age and disease stage help to predict prognosis. | Jia-Jia Chen Jian-Rong Huang Qian Yang Xiao-Wei Xu Xiao-Li Liu Shao-Rui Hao Hui-Fen Wang Tao Han Jing Zhang Jian-He Gan Zhi-Liang Gao Yu-Ming Wang Shu-Mei Lin Qing Xie Chen Pan Lan-Juan Li | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 48 |
| 2 | Scalable production of self-supported WSe/CNFs by electrospinning as the anode for high-performance lithium-ion batteries显示文摘 | Shasha Zhou Junnian Chen Lin Gan Qing Zhang Zhi Zheng Huiqiao Li Tianyou Zhai | 2016 | Science Bulletin2016，61，3： | 11 |
| 3 | An ion-imprinted polymer supported by attapulgite with a chitosan incorporated sol-gel process for selective separation of Ce(Ⅲ)显示文摘The surface ion-imprinting concept and chitosan incorporated sol-gel process were applied to the synthesis of a new attapulgitesupported polymer for selective separation of Ce(Ⅲ) from aqueous solution.The imprinting mechanism of prepared ion-imprinted polymer were discussed with the Characteristics of FT-IR and SEM.Results from the experiments of adsorption capacity and selectivity suggested that ion-imprinted polymer offered a fast kinetics for the adsorption of Ce(Ⅲ) under the optimum conditions. Its maximum adsorption capacity was 38.02 mg/g,and the selective recognition towards Ce(Ⅲ) was much higher than that of the non-imprinted polymer and attapulgite.The prepared functional polymer was shown to be promising for selective separation and enrichment of trace Ce(Ⅲ) in environmental samples. | Chun Xiang Li Jian Ming Pan Jie Gao Yong Sheng Yan Gan Qing Zhao | 2009 | Chinese Chemical Letters2009，20，8： | 6 |
| 4 | Association between socioeconomic status and chronic obstructive pulmonary disease in Jiangsu province, China: a population-based study显示文摘Background:Chronic obstructive pulmonary disease(COPD)is a common public health problem worldwide.Recent studies have reported that socioeconomic status(SES)is related to the incidence of COPD.This study aimed to investigate the association between SES and COPD among adults in Jiangsu province,China,and to determine the possible direct and indirect effects of SES on the morbidity of COPD.Methods:A cross-sectional study was conducted among adults aged 40 years and above between May and December of 2015 in Jiangsu province,China.Participants were selected using a multistage sampling approach.COPD,the outcome variable,was diagnosed by physicians based on spirometry,respiratory symptoms,and risk factors.Education,occupation,and monthly family average income(FAI)were used to separately indicate SES as the explanatory variable.Mixed-effects logistic regression models were introduced to calculate odds ratios(ORs)and 95%confidence intervals(CIs)for examining the SES-COPD relationship.A pathway analysis was conducted to further explore the pulmonary function impairment of patients with different SES.Results:The mean age of the 2421 participants was 56.63±9.62 years.The prevalence of COPD was 11.8%(95%CI:10.5%–13.1%)among the overall sample population.After adjustment for age,gender,residence,outdoor and indoor air pollution,body weight status,cigarette smoking,and potential study area-level clustering effects,educational attainment was negatively associated with COPD prevalence in men;white collars were at lower risk(OR:0.60,95%CI:0.43–0.83)of experiencing COPD than blue collars;compared with those within the lower FAI subgroup,participants in the upper(OR:0.68,95%CI:0.49–0.97)tertiles were less likely to experience COPD.Such negative associations between all these three SES indicators and COPD were significant among men only.Education,FAI,and occupation had direct or indirect effects on pulmonary function including post-bronchodilator forced expiratory volume in 1 s/forced vital capacity(FEV1/FVC),FEV1,FVC,and FEV1 percentage of predicted.Education,FAI,and occupation had indirect effects on pulmonary function indices of all participants mainly through smoking status,indoor air pollution,and outdoor air pollution.We also found that occupation could affect post-bronchodilator FEV1/FVC through body mass index.Conclusions:Education,occupation,and FAI had an adverse relationship with COPD prevalence in Jiangsu province,China.SES has both direct and indirect associations with pulmonary function impairment.SES is of great significance for COPD morbidity.It is important that population-based COPD prevention strategies should be tailored for people with different SES. | Dan-Dan Zhang Jian-Nan Liu Qing Ye Zi Chen Ling Wu Xue-Qing Peng Gan Lu Jin-Yi Zhou Ran Tao Zhen Ding Fei Xu Linfu Zhou | 2021 | Chinese Medical Journal2021，，13： | 5 |
| 5 | Impact Factor:1.90 Total flavonoids from Saussurea involucrata attenuate inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages via modulating p65,c-Jun,and IRF3 signaling pathways显示文摘Objective:To investigate the anti-inflammatory effects of the total flavonoids from Saussurea involucrata on lipopolysaccharides(LPS)-stimulated murine RAW264.7 macrophages and explore its underlying mechanism of action.Methods:Total flavonoids from Saussurea involucrata were extracted using chromatographic column method.Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.The production of nitric oxide was detected by Griess assay and the release of cytokines(IL-10 and TNF-α)and chemokines(MCP-1,MIP-1α,and CCL5/RANTES)was determined by ELISA to evaluate the anti-inflammatory activity of total flavonoids from Saussurea involucrata.Moreover,nuclear translocation of p65,c-Jun,and IRF3 was detected by immunofluorescence microscopy and Western blotting analysis was performed to determine the expression of related proteins.Results:Total flavonoids extracted from Saussurea involucrata were 751.5 mg/g and the content of rutin was 506.5 mg/g.The production of inflammatory mediators including nitric oxide,cytokines,and chemokines was effectively inhibited by total flavonoids from Saussurea involucrata.Meanwhile,total flavonoids also suppressed the nuclear translocation of p65,c-Jun,and IRF3 in LPS-stimulated RAW264.7 cells.The LPS-induced expression of iNOS and COX-2 was remarkably reduced by treatment with total flavonoids from Saussurea involucrata.Moreover,total flavonoids decreased the expression levels of p-IKKα/β,p-TBK1,p-p38,p-ERK,p-JNK,p-p65,p-c-Jun,and p-IRF3 in LPS-exposed RAW264.7 macrophages.Conclusions:Total flavonoids from Saussurea involucrata potentially inhibit the secretion of pro-inflammatory mediators,which may be related to inhibition of p65,c-Jun,and IRF3 signaling pathways in LPS-stimulated RAW264.7 cells. | Li-Shan Yan Li Wang Brian Chi-Yan Cheng Yu Ding Jing Kong Qing Gao Wang Xiu-Qiong Fu Shuo-Feng Zhang Gan Luo Yi Zhang | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，6： | 3 |
| 6 | Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer显示文摘Oxaliplatin is widely used in the frontline treatment of colorectal cancer(CRC),but an estimated 50%of patients will eventually stop responding to treatment due to acquired resistance.This study revealed that diminished MEIS1 expression was detected in CRC and harmed the survival of CRC patients.MEIS1 impaired CRC cell viabilities and tumor growth in mice and enhanced CRC cell sensitivity to oxaliplatin by preventing DNA damage repair.Mechanistically,oxaliplatin resistance following MEIS1 suppression was critically dependent on enhanced FEN1 expression.Subsequently,we confirmed that EZH2-DNMT3a was assisted by lncRNA ELFN1-AS1 in locating the promoter of MEIS1 to suppress MEIS1 transcription epigenetically.Based on the above,therapeutics targeting the role of MEIS1 in oxaliplatin resistance were developed and our results suggested that the combination of oxaliplatin with either ELFN1-AS1 ASO or EZH2 inhibitor GSK126 could largely suppress tumor growth and reverse oxaliplatin resistance.This study highlights the potential of therapeutics targeting ELFN1-AS1 and EZH2 in cell survival and oxaliplatin resistance,based on their controlling of MEIS1 expression,which deserve further verification as a prospective therapeutic strategy. | Yimin Li Yaqi Gan Jiaxin Liu Juanni Li Zhengwei Zhou Ruotong Tian Ruizheng Sun Jiaqi Liu Qing Xiao Yuanyuan Li Pengyan Lu Yulong Peng Yuqian Peng Guang Shu Gang Yin | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 7 | Diagnosis,treatment,and prevention of severe acute hepatitis of unknown etiology in children显示文摘Background Severe acute hepatitis of unknown etiology in children has recently exhibited a global trend of concentrated occurrence.This review aimed to summarize the current available information regarding the outbreak of severe acute hepatitis and introduce our hospital’s previous experiences with the diagnosis and treatment of severe acute hepatitis for reference.Data sources Websites including the UK Health Security Agency,European Centre for Disease Prevention and Control,CDC,WHO,and databases including PubMed/Medline,Cochrane Library,Embase and Web of Science were searched for articles on severe acute hepatitis in children.Results As of May 26,2022,a total of 650 cases have been reported in 33 countries;at least 38(6%)children required liver transplantation,and nine(1%)died.Cases are predominantly aged between 3 and 5 years old,and there are no epidemiological links among them.The common manifestations are jaundice,vomiting and pale stools.Adenovirus tested positive in most cases,and SARS-CoV-2 and other viruses were detected in a few cases,but virus particles were not found in liver tissue.Adenovirus immunohistochemistry showed immunoreactivity in the intrasinusoidal lumen from some liver samples.The hierarchical treatment includes symptomatic and supportive therapy,management of coagulation disorders and hepatic encephalopathy,artifcial liver support,and liver transplantation(approximately 6%–10%of cases require liver transplant).Conclusions The etiology of this severe acute hepatitis in children is not clear.The clinical features are severe acute hepatitis with signifcantly elevated liver enzymes.Clinicians need to be alert to children with hepatitis. | Ying‑Hu Chen Jin‑Gan Lou Zi‑Hao Yang Qing‑Jiang Chen Chun‑Zhen Hua Sheng Ye Chen‑Mei Zhang Jie Chen Zong‑Wei Huang Jin‑Dan Yu Zhi‑Gang Gao Qiang Shu | 2022 | World Journal of Pediatrics2022，18，8： | 2 |
| 8 | Environmental fate and effects of organophosphate flame retardants in the soil-plant system显示文摘Organophosphate flame retardants(OPFRs),as a replacement for polybrominated diphenyl ethers(PBDEs),are of increasing concern due to their high production over the years.Soil is the major environmental reservoir and interchange for OPFRs.OPFRs in soil could be transferred to the food chain,and pose potential ecological and human health risks.This review focused on the environmental fate and effects of typical OPFRs in the soil-plant system.We concluded that the sorption and transformation behaviors of OPFRs due to their crucial impact on bioavailability.The root uptake and translocation of OPFRs by plants were summarized with analyses of their potential affecting factors.The in planta transformation and potential ecological effects of OPFRs were also briefly discussed.Finally,we highlighted several research gaps and provided suggestions for future research,including the development of simulative/computative methods to evaluate the bioavailability of OPFRs,the effects of root exudates and rhizosphere microorganisms on the bioavailability and plant uptake of OPFRs,and the development of green and sustainable technologies for in situ remediation of OPFRs-contaminated soil. | Qing Zhang Weiping Mei Longfei Jiang Qian Zheng Chunling Luo Gan Zhang | 2021 | Soil Ecology Letters2021，3，3： | 2 |
| 9 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 10 | Sidebang Suppression inTime- Modulated Linear Arrays by the Differential Evolution Algo-rithm 显示文摘 | Yang Shi wen Gan Y B Qing Anyong | 2002 | IEEE Trans on Antennas and Wireless Propagation Let-ters2002，1，1： | 1 |
| 11 | Exploring determinants of voting for the 'helpfulness' of online user reviews: a text mining approach 显示文摘 | Cao Qing Duan Wenjing Gan Qiwei | 2011 | Decision Support Systems2011，50，2： | 1 |
| 12 | Moving phase center antenna arrays with optimized static excitations显示文摘 | Yang S W Gan Y B Qing A Y | 2003 | Microwave and Optical Technology Letters2003，38，1： | 1 |
| 13 | Sideband suppression intime modulated linear arrays by the differential evolutionalgorithm显示文摘 | YANG S GAN Y B QING A | 2002 | IEEE Antennas Wireless Propagation Let-ters2002，，1： | 1 |
| 14 | Effect of Water Chestnut Powder on Gel Properties of Silver Carp Surimi显示文摘[Objectives]The effects of water chestnut powder on the gel properties and quality of silver carp surimi were investigated.[Methods]The surimi gel was prepared by adding 0%,1%,2%,3%,4%and 5%of water chestnut powder to the surimi of silver carp.The gel properties,water-holding capacity,cooking loss,whiteness value,puncture and texture profile analysis(TPA)indexes of surimi products were determined to assess the effects of adding different amounts of water chestnut powder on surimi gel.[Results]The results showed that the gel strength,breaking force and depression distance of surimi products increased first and then decreased with the increase of the addition of water chestnut powder.Compared with the control group,the hardness and chewiness of surimi gel in TPA could be significantly improved by adding water chestnut powder.When the addition of water chestnut powder was 2%,the maximum water-holding capacity was 83.68%;the cooking loss rate was the lowest;and the whiteness value was the highest.Adding 2%of water chestnut powder could significantly improve the gel properties of silver carp surimi and obtain a good gel product.[Conclusions]This study provides a scientific basis for the effective utilization of water chestnut resources and the development of new fish surimi products. | Jialin XIE Qing GAN Hui CHEN Zhuoya LUO Di TIAN Ruying HE Peng WU | 2022 | Agricultural Biotechnology2022，11，6： | 1 |
| 15 | Exploring Determinants of Voting for the 'Helpfulness' of Online User Reviews: A Text Mining Approach 显示文摘 | Qing Cao Wenjing Duan Qiwei Gan | 2011 | Decision Support Systems2011，50，2： | 1 |
| 16 | Intranasal immunization with autolysin (LytA) in mice model induced protection against five prevalent Streptococcus pneurnoniae se- rotypes in China显示文摘 | Zhu Qing Yuan Zhi Yue Lv Hui Quan Gan | 2011 | Immunol Res2011，51，： | 1 |
| 17 | Significant enhancement of UV emission in ZnO nanorods subject to Ga+ ion beam irradiation显示文摘在光电子的 ZnO nanomaterials 的应用仍然由于他们的不够的光致发光效率被限制。以便优化 ZnO nanorods 的光致发光性质,在与在不同离子精力(0.5 keV16 keV ) 的 Ga + 离子照耀的关联,在 Si 底层上种的垂直地排列的 ZnO nanorods 的紫外排放在现在的学习被调查。我们发现紫外紧张与增加 Ga + 离子精力很快增加了,直到它在 2 keV,在点,紧张比由成长得当的 ZnO nanorods 生产了那高约 50 倍附近的最大值。低精力的 Ga + 离子的轻轻的轰炸把缺点从 ZnO nanorod 表面移开。在另一方面, Ga + 离子植入进 nanorods,导致压缩紧张。在表面缺点和压缩紧张的介绍的移动之上的水晶格子的完美的安排是贡献紫外轻产生的重要改进的二个因素,这被相信。 | Boluo Yadian Rui Chen Hai Liu Handong Sun Qing Liu Chee Lip Gan Zhou Kun Chunwang Zhao Bin Zhu Yizhong Huang | 2015 | Nano Research2015，8，6： | 1 |
| 18 | A case study of prob- lems in JEDEC HBM ESD test standard 显示文摘 | Huo Mingxu Guo Qing Gan Yan | 2009 | IEEE Transac- tions on Device and Materials Reliability2009，9，3： | 1 |
| 19 | Advance in the applications of konjac glucomannan and its derivatives 显示文摘 | ZHANG Ying - qing XIE Bi - jun GAN Xin | 2005 | Carbohydrate Polymers2005，60，： | 1 |
| 20 | Exploring determinants of voting for the 'Helpfulness' of online user reviews: A text mining proach显示文摘 | Cao Qing Duan Wenjing Gan Qiwei | 2011 | Decision Support Systems2011，50，2： | 1 |
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