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| 1 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 2 | Tracking control for multi-agent consensus with an active leader and variable topology显示文摘 | HONG Yiguang HU Jiangping GAO Linxin | 2006 | Automatica2006，42，7： | 1 |
| 3 | LMI-based robust H∞ control of uncertain linear jump systems with time-delays显示文摘 | Gao Jiangping Huang Biao Wang Zidong | 2001 | Automatic2001，，37： | 1 |
| 4 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 5 | Tracking control for multi-agent consensus with an active leader and variable topology显示文摘 | HONG Yiguang HU Jiangping GAO Linxin | 2006 | Automatica2006，42，7： | 1 |
| 6 | Tracking control for multi-agent consensus with an active leader and variable topology显示文摘 | Yiguang Hong Jiangping Hu Linxin Gao | 2006 | Automatica2006，，7： | 1 |
| 7 | Tracking control for multi-agent consensus with an active leader and variable topology显示文摘 | HONG YIGUANG HU JIANGPING GAO LINXIN | 2006 | Automatica2006，42，7： | 1 |
| 8 | Photoresponse Process and Model Comparison of Paeonia ludlowii under Saline-alkali Stress显示文摘The research aimed to analyze changes in photosynthetic characteristics of Paeonia ludlowii under saline-alkali stress, and annual seedlings of P. ludlowii were taken as the materials. Photoresponse process of P. ludlowii leaves under saline-alkali stress was simulated, and different models were used to fit photoresponse curve. The results showed that P n of P. ludlowii leaves showed the trend of first rising and then declining with PAR increased under saline-alkali stress;both G s and T r showed a rising trend with PAR increased;C i showed the trend of first declining and then rising with PAR increased. Photoresponse curve fitted by modified rectangular hyperbolic model had the best effect, and it was the optimal fitting model. P. ludlowii could adapt to saline-alkali stress in lower concentration, showing that P. ludlowii could be introduced and cultivated in saline-alkali land at a lower level. | Ge Qingsong Gao Yi Wang Hang Fang Jiangping | 2019 | Meteorological and Environmental Research2019，10，4： | 0 |
| 9 | Insights into genetic diversity and phenotypic variations in domestic geese through comprehensive population and pan-genome analysis显示文摘Background Domestic goose breeds are descended from either the Swan goose(Anser cygnoides)or the Greylag goose(Anser anser),exhibiting variations in body size,reproductive performance,egg production,feather color,and other phenotypic traits.Constructing a pan-genome facilitates a thorough identification of genetic variations,thereby deepening our comprehension of the molecular mechanisms underlying genetic diversity and phenotypic variability.Results To comprehensively facilitate population genomic and pan-genomic analyses in geese,we embarked on the task of 659 geese whole genome resequencing data and compiling a database of 155 RNA-seq samples.By constructing the pan-genome for geese,we generated non-reference contigs totaling 612 Mb,unveiling a collection of 2,813 novel genes and pinpointing 15,567 core genes,1,324 softcore genes,2,734 shell genes,and 878 cloud genes in goose genomes.Furthermore,we detected an 81.97 Mb genomic region showing signs of genome selection,encompassing the TGFBR2 gene correlated with variations in body weight among geese.Genome-wide association studies utilizing single nucleotide polymorphisms(SNPs)and presence-absence variation revealed significant genomic associations with various goose meat quality,reproductive,and body composition traits.For instance,a gene encoding the SVEP1 protein was linked to carcass oblique length,and a distinct gene-CDS haplotype of the SVEP1 gene exhibited an association with carcass oblique length.Notably,the pan-genome analysis revealed enrichment of variable genes in the“hair follicle maturation”Gene Ontology term,potentially linked to the selection of feather-related traits in geese.A gene presence-absence variation analysis suggested a reduced frequency of genes associated with“regulation of heart contraction”in domesticated geese compared to their wild counterparts.Our study provided novel insights into gene expression features and functions by integrating gene expression patterns across multiple organs and tissues in geese and analyzing population variation.Conclusion This accomplishment originates from the discernment of a multitude of selection signals and candidate genes associated with a wide array of traits,thereby markedly enhancing our understanding of the processes underlying domestication and breeding in geese.Moreover,assembling the pan-genome for geese has yielded a comprehensive apprehension of the goose genome,establishing it as an indispensable asset poised to offer innovative viewpoints and make substantial contributions to future geese breeding initiatives. | Guangliang Gao Hongmei Zhang Jiangping Ni Xianzhi Zhao Keshan Zhang Jian Wang Xiangdong Kong Qigui Wang | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 10 | Phenotypic Diversity of Different Populations of Paeonia ludlowii in Nyingchi of Tibet显示文摘[Objectives] To study the differences in fruit traits of different populations of Paeonia ludlowii , and to provide basic data for the identification, protection and utilization of germplasm resources of P. ludlowii .[Methods] Nine fruit traits of three different populations of P. ludlowii in Tibet were tested and analyzed.[Results] The mean values of 9 fruit traits of P. ludlowii were different in different populations;the coefficients of variation of different traits of different populations were also different;there were morphological differences of different sizes among individuals in each population;there were significant differences in 8 traits (pod length, pod width, pod thickness, pod weight, seeds per pod, seed length, seed width, and seed weight) among different populations. Among the 9 traits of the three P. ludlowii populations, the variability of the five traits was higher in the fruit pods, the variation degree of five traits including pod weight, pod thickness, seeds per pod, and seed weight was higher. It is of great significance for the screening and preservation of the germplasm resources of P. ludlowii . According to the principal component analysis (PCA), the seed weight, seed width, and seed length, i.e. the seed traits, were the main factors causing differences in fruit traits among populations. There was a certain correlation between different traits of P. ludlowii . Among the 36 Pearson- related combinations of 9 fruit traits, 11 combinations had extremely significant correlations, and 8 combinations had significant correlations, indicating that there was a certain correlation between fruit traits in the growth and development. Through cluster analysis, three populations of P. ludlowii can be divided into two categories. The BV population was a category, which is characterized by long pods, long seeds, wide seeds, thick seeds and large seed weight. Therefore, the BV population is suitable material for breeding excellent varieties.[Conclusions] This study provides basic data for the identification, protection and utilization of germplasm resources of P. ludlowii . | Qingsong GE Yi GAO Hang WANG Jiangping FANG | 2019 | Medicinal Plant2019，10，4： | 0 |
| 11 | Genome resequencing reveals the evolutionary history of garlic reproduction traits显示文摘The propagation of cultivated garlic relies on vegetative cloves,thus flowers become non-essential for reproduction in this species,driving the evolution of reproductive feature-derived traits.To obtain insights into the evolutionary alteration of reproductive traits in the clonally propagated garlic,the evolutionary histories of two main reproduction-related traits,bolting and flower differentiation,were explored by genome analyses using 134 accessions displaying wide diversity in these two traits.Resequencing identified 272.8 million variations in the garlic genome,198.0million of which represent novel variants.Population analysis identified five garlic groups that have evolved into two clades.Gene expression,single-cell transcriptome sequencing,and genome-wide trait association analyses have identified numerous candidates that correlate with reproductive transition and flower development,some of which display distinct selection signatures.Selective forces acting on the B-box zinc finger protein-encoding Asa2G00291.1,the global transcription factor group E protein-encoding Asa5G01527.1,and VERNALIZATION INSENSITIVE 3-like Asa3G03399.1 appear to be representative of the evolution of garlic bolting.Plenty of novel genomic variations and trait-related candidates represent valuable resources for biological studies of garlic.Numerous selective signatures from genes associated with the two chosen reproductive traits provide important insights into the evolutionary history of reproduction in this clonally propagated crop. | Haiping Wang Einat Shemesh-Mayer Jiangjiang Zhang Song Gao Zheng Zeng Zemao Yang Xueyu Zhang Huixia Jia Yanzhou Wang Jiangping Song Xiaohui Zhang Wenlong Yang Qiaoyun He Amir Sherman Lin Li Rina Kamenetsky Touming Liu | 2023 | Horticulture Research2023，10，11： | 0 |
| 12 | Effect of Acid and Alkali Stress on Seed Germination and Seedling Growth of Caragana versicolor显示文摘With seeds of Caragana versicolor in Purang County, Tibet as the materials, the seed germination and seedling growth of C. versicolor were measured under acid and alkali stress, and the soil acidity and alkalinity for normal growth and development of C. versicolor were determined, so as to provide the theoretical basis for cultivation of C. versicolor in acidified or alkaline soil. The results showed that the seed germination of C. versicolor was promoted when treated by strong acid (pH 3) and strong alkali (pH 11) solutions, and the seedling effect was good. The results also indicated that C. versicolor was a kind of plant with strong acid and alkali resistance, suitable for cultivation in acid and alkali soil areas. | Ge Qingsong Wang Hang Gao Yi Fang Jiangping | 2019 | Animal Husbandry and Feed Science2019，11，2： | 0 |
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