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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 3 | P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent,but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells显示文摘瞄准:在 vitro 在导致 oridonin 的 MCF-7human 乳癌房间 apoptosis 学习 caspase-3-independent 机制。方法:oridonintreated MCF-7 房间的生存能力被 MTT (thiazole 蓝色) 测量试金。有压缩原子核的 Apoptotic 房间被阶段对比显微镜学设想。Nucleosomal DNA 破碎是由统帅玫瑰胶化电气泳动的 assayed。apoptotic 比率被决定由喂奶脱氢酶试金。房间周期引申 andmitochondrial 膜潜力被流动 cytometric 分析测量。Bax, Bcl-2, caspase-3, caspase-9,热吃惊蛋白质(Hsp ) 90, p53, p-p53, p21,(自动数据处理核糖) Poly,聚合酶(PARP ) ,和激活 caspase 的 DNase (ICAD ) 蛋白质表情的禁止者被西方的污点分析检测。结果:Oridonin 在一个时间依赖者和剂量依赖者举止禁止了房间生长。房间周期被改变通过起来 p53 和 p21 蛋白质表情的规定。Pancaspase inhibitorZ-VAD-fmk 和 calpain 禁止者 II 两个都减少了房间死亡比率。Nucleosomal DNA 破碎并且下面 DeltaPhimit 的规定在导致 oridonin 的 MCF-7 房间 apoptosis 被检测,它涉及一条 postmitochondrial caspase-9-dependent 小径。减少的 Bcl-2 和 Hsp90expression 层次和 p21 表示层次断然与 phosphorylated p53 phosphorylation 的提高的层次被相关。而且, PARP 部分被劈开 bycalpain 而非由 capase-3。结论:DNA 损坏在线粒体陆地 caspase-9 小径以及调停 p53 的房间周期拘捕挑起了引申,但是不与在导致 oridonin 的 MCF-7 房间的 caspase-3activity 有关。 | Qiao CUI Jing-hua YU Jin-nan WU Shin-ichi TASHIRO Satoshi ONODERA Mutsuhiko MINAMI Takashi IKFJIMA | 2007 | Acta Pharmacologica Sinica2007，28，7： | 30 |
| 4 | Pseudolaric acid B induces apoptosis,senescence,and mitotic arrest in human breast cancer MCF-7显示文摘目的:现在的学习的目的是在人的乳癌 MCF-7 cells.Methods:3-( 4,5-dimethylthiazol-2-yl )上调查 pseudolaric 酸 B ( PAB )的禁止的效果 -2,5-diphenyltetrazolium 溴化物分析,词法变化,染色的吖啶橙,并且统帅玫瑰胶化电气泳动被使用检测 apoptotic 的 apoptosis.The 百分比,坏死的房间被lactate 脱氢酶计算基于活动的细胞毒性试金;联系的老朽( SA ) -beta-galactosidase 活动被检测评估老朽; propidium 碘化物染色的流动 cytometric 分析被执行调查房间周期的分发,并且蛋白质表示被西方的污点 analysis.Results 检验:在 apoptosis 期间,半最大的禁止的集中 IC50 是在在 PAB 治疗以后的 36 和 48 h 的 3.4 和 1.35 亩 mol/L ,暴露于 PAB 的 respectively.The MCF-7 房间显示出 apoptosis 的典型特征,包括词法变化和 DNA 破碎。为 36 h 与 4 亩 mol/L PAB 对待的 MCF-7 房间经历了 apoptosis,然而并非坏死。PAB 导致的 apoptosis 独立于死亡受体小径。衰老的房间变得更大并且恭维,并且染色的 SA-p-galactosi-dase 是导致的 positive.PAB 明显的有丝分裂的拘捕和它先于 apoptosis 和老朽。p21 和 p53 的表情起来与 PAB 处理调整了,并且 cyclin B1 起来从细胞质调整了并且搬运,并且支撑了稳定的 levels.Conclusion 到原子核: PAB 在 MCF-7 房间导致了有丝分裂的拘捕并且通过 apoptosis 和老朽禁止了增长。apoptosis 独立于死亡受体小径。 | Jing-hua YU Qiao CUI Yuan-yuan JIANG Wei YANG Shin-ichi TASHIRO Satoshi ONODERA Takashi IKEJIMA | 2007 | Acta Pharmacologica Sinica2007，28，12： | 22 |
| 5 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 6 | Target selection and transfer trajectories design for exploring asteroid mission显示文摘Technique of target selection and profiles of transfer trajectory for Chinese asteroid exploring mission are studied systemically.A complete set of approaches to selecting mission targets and designing the transfer trajectory is proposed.First,when selecting a target for mission,some factors regarded as the scientific motivations are discussed.Then,when analyzing the accessibility of targets,instead of the classical strategy,the multiple gravity-assist strategy is provided.The suitable and possible targets,taking into account scientific value and technically feasible,are obtained via selection and estimation.When designing the transfer trajectory for exploring asteroid mission,an approach to selecting gravity-assist celestial body is proposed.Finally,according to the mission constraints,the trajectory profile with 2-years △V-EGA for exploring asteroid is presented.Through analyzing the trajectory profile,unexpected result that the trajectory would pass by two main-belts asteroids is found.So,the original proposal is extended to the multiple flybys mission.It adds the scientific return for asteroid mission. | CUI PingYuan1,QIAO Dong1,CUI HuTao2 & LUAN EnJie3 1 School of Aerospace Engineering,Beijing Institute of Technology,Beijing 100081,China 2 Harbin Institute of Technology,Harbin 150001,China 3 National Defense Science and Industry Bureau,Beijing 100048,China | 2010 | Science China(Technological Sciences)2010，53，4： | 15 |
| 7 | Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly显示文摘AIM:To evaluate human gastric submucosal vascular dysfunction and its mechanism during the aging process.METHODS:Twenty male patients undergoing subtotal gastrectomy were enrolled in this study.Young and elderly patient groups aged 25-40 years and 60-85 years,respectively,were included.Inclusion criteria were:no clinical evidence of cardiovascular,renal or diabetic diseases.Conventional clinical examinations were carried out.After surgery,gastric submucosal arteries were immediately dissected free of fat and connective tissue.Vascular responses to acetylcholine(ACh)and sodium nitroprusside(SNP)were measured by isolated vascular perfusion.Morphological changes in the gastric mucosal vessels were observed by hematoxylin and eosin(HE)staining and Verhoeff van Gieson(EVG)staining.The expression of xanthine oxidase(XO)and manganese-superoxide dismutase(Mn-SOD)was assessed by Western blotting analysis.The malondialdehyde(MDA)and hydrogen peroxide(H2O2)content and the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were determined according to commercial kits.RESULTS:The overall structure of vessel walls was shown by HE and EVG staining,respectively.Disruption of the internal elastic lamina or neointimal layers was not observed in vessels from young or elderly patients;however,cell layer number in the vessel wall increased significantly in the elderly group.Compared with submucosal arteries in young patients,the amount of vascular collagen fibers,lumen diameter and media cross-sectional area were significantly increased in elderly patients.Ach-and SNP-induced vasodilatation in elderly arterioles was significantly decreased compared with that of gastric submucosal arterioles from young patients.Compared with the young group,the expression of XO and the contents of MDA and H2O2in gastric submucosal arterioles were increased in the elderly group.In addition,the expression of Mn-SOD and the activities of SOD and GSH-Px in the elderly group decreased significantly compared with those in the young group.CONCLUSION:Gastric vascular dysfunction and senescence may be associated with increased oxidative stress and decreased antioxidative defense in the aging process. | Lei Liu Yan Liu Jie Cui Hong Liu Yan-Bing Liu Wei-Li Qiao Hong Sun Chang-Dong Yan | 2013 | World Journal of Gastroenterology2013，19，48： | 14 |
| 8 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 9 | Type Ⅳ secretion system in Helicobacter pylori:a new insight into pathogenicity显示文摘在数据在这评论使用了的 Helicobacter pylori.Data 来源在类型 IV 分泌物系统( T4SS )上考察研究进步的目的被在网上 PUBMED ( 1995-2007 )寻找识别这的主要先驱调查者写的主要原来的文章和批评评论回答的资源学习选择是 selected.Results 研究进步在在 Helicobacter pylori 的 T4SS 上是 summarized.The 结构,函数是 discussed.Conclusions T4SS 不仅在毒素 secretio | ZHONG Qiao SHAO Shi-he CUI Lei-lei MU Run-hong JU Xiao-li DONG Su-rong | 2007 | Chinese Medical Journal2007，，23： | 9 |
| 10 | Optimized design and test for a pendulum suspension of the crop spray boom in dynamic conditions based on a six DOF motion simulator显示文摘Spray deposit distribution from a field sprayer is mainly affected by the boom movements when the tractor is driven over a rough soil surface,the pendulum suspension that used to reduce and control the movement of spray boom by isolating the boom from vibrations of the tractor will directly enhance uniform deposition of chemicals.However,how to match the parameters of the suspension with the properties of the boom is the key problem.The dynamic rigid-flexible coupling model of the virtual prototype of the spray boom suspension system was established by using ADAMS and ABAQUS software.An optimization of the suspension parameters for a large spay boom was carried out based on the optimal Latin hypercube design,radial basis function neural network,and multi-objective genetic algorithm NSGA-II.After modified parameters of the suspension,the travel of the sprayer on a typical field motion track was simulated based on a six DOF motion simulator,and the dynamic behavior of the boom suspension was measured.The results show that RMS of the measured boom roll angle and the boom center displacement for optimized solution were reduced by 14.76%and 12.43%compared with the original suspension.Finally,the inertial measurement unit(IMU)was used to measure the movements of the sprayer vehicle during the pesticide application on the Hongze Lake Farm,the experiment of field condition reproduced by using the six DOF motion simulator,the standard deviation of the roll angle and vibration displacement for the optimized sprayer boom are only 0.6382°and 62.279 mm respectively.The research provides theoretical basis and experimental method for parameter optimization of large scale boom suspension. | Longfei Cui Hanping Mao Xinyu Xue Suming Ding Baiyu Qiao | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 9 |
| 11 | New sensor technologies in quality evaluation of Chinese materia medica:2010–2015显示文摘New sensor technologies play an important role in quality evaluation of Chinese materia medica(CMM) and include near-infrared spectroscopy,chemical imaging,electronic nose and electronic tongue.This review on quality evaluation of CMM and the application of the new sensors in this assessment is based on studies from 2010 to 2015,with prospects and opportunities for future research. | Xiaosu Miao Qingyu Cui Honghui Wu Yanjiang Qiao Yanfei Zheng Zhisheng Wu | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 7 |
| 12 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044s6xk6of655vwv6695.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 13 | Scale-up of a high shear wet granulation process using a nucleation regime map approach显示文摘 | Gan Luo Bing Xu Yi Zhang Xianglong Cui Jianyu Li Xinyuan Shi Yanjiang Qiao | 2017 | Particuology2017，15，2： | 7 |
| 14 | Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells显示文摘Objective:Although T-cell immunoglobulin and mucin-domain containing molecule-3(Tim-3)has been recognized as a promising target for cancer immunotherapy,its exact role in breast cancer has not been fully elucidated.Methods:Tim-3 gene expression in breast cancer and its prognostic significance were analyzed.Associated mechanisms were then explored in vitro by establishing Tim-3-overexpressing breast cancer cells.Results:In a pooled analysis of The Cancer Genome Atlas(TCGA)database,Tim-3 gene expression levels were significantly higher(P<0.001)in breast cancer tissue,compared with normal tissues.Tim-3 was a prognosis indicator in breast cancer patients[relapse-free survival(RFS),P=0.004;overall survival(OS),P=0.099].Tim-3 overexpression in Tim-3 low breast cancer cells promoted aggressiveness of breast cancer cells,as evidenced by enhanced proliferation,migration,invasion,tight junction deterioration and tumor-associated tubal formation.Tim-3 also enhanced cellular resistance to paclitaxel.Furthermore,Tim-3 exerted its function by activating the NF-κB/STAT3 signalling pathway and by regulating gene expression[cyclin D1(CCND1),C-Myc,matrix metalloproteinase-1(MMP1),TWIST,vascular endothelial growth factor(VEGF)upregulation,concomitant with Ecadherin downregulation).Lastly,Tim-3 downregulated tight junction-associated molecules zona occludens(ZO)-2,ZO-1 and occludin,which may further facilitate tumor progression.Conclusions:Tim-3 plays an oncogenic role in breast cancer and may represent a potential target for antitumor therapy. | Yizi Cong Yuxin Cui Shiguang Zhu Jianqiao Cao Haidong Zou Tracey AMartin Guangdong Qiao Wenguo Jiang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 7 |
| 15 | Hepatic ectopic pregnancy treated successfully by hepatectomy显示文摘Hepatic ectopic pregnancies are extremely rare and can be associated with excessive maternal morbidity and mortality.1 Given the rarity of such a form of ectopic pregnancy and the associated potential mortality,early diagnosis and appropriate treatment is essential.We present a unique case of an ectopic pregnancy with a 10-week-old fetus implanted on the liver,which was treated successfully by hepatic resection. | QIAO Jiang-chun CHANG Zhi-gang WEI Jun-min LIU Yan-nan CUI Hong-yuan ZHANG Yi | 2013 | Chinese Medical Journal2013，，24： | 6 |
| 16 | Anti-Hypertensive Action of Fenofibrate via UCP2 Upregulation Mediated by PPAR Activation in Baroreflex Afferent Pathway显示文摘Fenofibrate, an agonist for peroxisome proliferator-activated receptor alpha(PPAR-a), lowers blood pressure, but whether this action is mediated via baroreflex afferents has not been elucidated. In this study, the distribution of PPAR-a and PPAR-c was assessed in the nodose ganglion(NG) and the nucleus of the solitary tract(NTS). Hypertension induced by drinking high fructose(HFD) was reduced, along with complete restoration of impaired baroreceptor sensitivity, by chronic treatment with fenofibrate. The molecular data also showed that both PPAR-a and PPAR-c were dramatically up-regulated in the NG and NTS of the HFD group. Expression of the downstream signaling molecule of PPAR-a, the mitochondrial uncoupling protein 2(UCP2), was up-regulated in the baroreflex afferent pathway under similar experimental conditions, along with amelioration of reduced superoxide dismutase activity and increased superoxide in HFD rats.These results suggest that chronic treatment with fenofibrate plays a crucial role in the neural control of blood pressure by improving baroreflex afferent function due at least partially to PPAR-mediated up-regulation of UCP2 expression and reduction of oxidative stress. | Jian Guan Miao Zhao Chao He Xue Li Ying Li Jie Sun Wei Wang Ya-Li Cui Qing Zhang Bai-Yan Li Guo-Fen Qiao | 2019 | Neuroscience Bulletin2019，35，1： | 5 |
| 17 | Impacts of smoking status on the clinical outcomes of coronary non-target lesions in patients with coronary heart disease:a single-center angiographic study显示文摘Background:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events.This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.Methods:Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included.All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures.Patients were grouped into non-smokers,quitters,and smokers according to their smoking status.Clinical outcomes including rapid lesion progression,lesion re-vascularization,and myocardial infarction were recorded at second coronary angiography.Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.Results:A total of 1255 patients and 1670 lesions were included.Smokers were younger and more likely to be male compared with nonsmokers.Increase in percent diameter stenosis was significantly lower(2.7[0.6,7.1]%vs.3.5[0.9,8.9]%)and 3.4[1.1,7.7]%,P=0.020)in quitters than those in smokers and non-smokers.Quitters tended to have a decreased incidence of rapid lesions progression(15.8%[76/482]vs.21.6%[74/342]and 20.6%[89/431],P=0.062),lesion re-vascularization(13.1%[63/482]vs.15.5%[53/432]and 15.5%[67/431],P=0.448),lesion-related myocardial infarction(0.8%[4/482]vs.2.6%[9/342]and 1.4%[6/431],P=0.110)and all-cause myocardial infarction(1.9%[9/482]vs.4.1%[14/342]and 2.3%[10/431],P=0.128)compared with smokers and non-smokers.In multivariable analysis,smoking status was not an independent predictor for rapid lesion progression,lesion re-vascularization,and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers(hazards ratio:3.00,95%confidence interval:1.04-8.62,P=0.042).Conclusion:Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions,meanwhile,smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers. | Hao-Bo Xu Juan Wang Ji-Lin Chen Chao Guo Jian-Song Yuan Xin Duan Feng-Huan Hu Wei-Xian Yang Xiao-Liang Luo Rong Liu Jin-Gang Cui Sheng-Wen Liu Xiao-Jin Gao Yu-Shi Chun Shu-Bin Qiao | 2020 | Chinese Medical Journal2020，，19： | 5 |
| 18 | Causes for different spatial distributions of minimum Arctic sea-ice extent in 2007 and 2012显示文摘Satellite records show the minimum Arctic sea ice extents(SIEs) were observed in the Septembers of 2007 and2012, but the spatial distributions of sea ice concentration reduction in these two years were quite different.Atmospheric circulation pattern and the upper-ocean state in summer were investigated to explain the difference.By employing the ice-temperature and ice-specific humidity(SH) positive feedbacks in the Arctic Ocean, this paper shows that in 2007 and 2012 the higher surface air temperature(SAT) and sea level pressure(SLP)accompanied by more surface SH and higher sea surface temperature(SST), as a consequence, the strengthened poleward wind was favorable for melting summer Arctic sea ice in different regions in these two years. SAT was the dominant factor influencing the distribution of Arctic sea ice melting. The correlation coefficient is –0.84 between SAT anomalies in summer and the Arctic SIE anomalies in autumn. The increase SAT in different regions in the summers of 2007 and 2012 corresponded to a quicker melting of sea ice in the Arctic. The SLP and related wind were promoting factors connected with SAT. Strengthening poleward winds brought warm moist air to the Arctic and accelerated the melting of sea ice in different regions in the summers of 2007 and 2012. Associated with the rising air temperature, the higher surface SH and SST also played a positive role in reducing summer Arctic sea ice in different regions in these two years, which form two positive feedbacks mechanism. | CUI Hongyan QIAO Fangli SHU Qi SONG Yajuan JIANG Chunfei | 2015 | Acta Oceanologica Sinica2015，34，9： | 5 |
| 19 | Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design显示文摘Acute respiratory distress syndrome(ARDS)is characterized by the severe inflammation and destruction of the lung aireblood barrier,leading to irreversible and substantial respiratory function damage.Patients with coronavirus disease 2019(COVID-19)have been encountered with a high risk of ARDS,underscoring the urgency for exploiting effective therapy.However,proper medications for ARDS are still lacking due to poor pharmacokinetics,non-specific side effects,inability to surmount pulmonary barrier,and inadequate management of heterogeneity.The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery.Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy,which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treatment.Through passive,active,or physicochemical targeting,nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment,thereby showing good therapeutic activity and reduced toxicity.This article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy,highlights the strategies for targeted treatment of lung inflammation,presents the innovative drug delivery systems,and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment. | Qi Qiao Xiong Liu Ting Yang Kexin Cui Li Kong Conglian Yang Zhiping Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 20 | Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients显示文摘AIM: To study the expression of cyclooxygenase-2 (COX-2)in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited cancer patients.METHODS: The expression of COX-2 mRNA in 38 patients with gastric cancer and their 29 first-degree relatives and 18 healthy controls was assessed by the real time RT-PCR.The expression of COX-2 protein was determined by Western blot.RESULTS: A marked increase in COX-2 mRNA expression was found in 20 of 37 (54%) cancerous tissues compared to their respective paired normal mucosa (P<0.001).Interestingly, increased COX-2 mRNA expression was also found in mucosa of the corpus (6/29) and antrum (13/29)of their first-degree relatives. Increased COX-2 mRNA expression was more frequently observed in the antrum biopsies from cancer patients than in the antrum biopsies from healthy controls (P<0.05). In addition, 3 of 23 (13%)patients with atrophic mucosa and 6 of 35 (17%) patients with intestinal metaplasia showed increased COX-2 mRNA expression. Furthermore, COX-2 expression increased in H pylori-positive tissues, especially in antrum mucosa.CONCLUSION: Increased COX-2 expression is involved in gastric carcinogenesis, and may be necessary for maintenance of the malignant phenotype and contribute to Helicobacterpylori-associated malignant transformation. | Jin-Ting Zhang ing-Wei Wang, Zhen-Long Zhu Xiao-Hui Huo Jian-Kun Chu Dong-Sheng Cui Liang Qiao Jun Yu | 2005 | World Journal of Gastroenterology2005，11，31： | 5 |
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