|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | Coronary bifurcation angle from 3-D predicts clinical outcomes after stenting bifurcation lesions显示文摘 | CHEN Shao-liang Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING Shi-qing Tak W Kwan | 2012 | Chinese Medical Journal2012，，12： | 2 |
| 3 | Use of a rapid mistach PCR method to dectect gyrA and part C mutations in ciprofloxacinresistant clinical isolates of Escherichia coli显示文摘 | Qiang YZ Qin T Fu W | 2002 | J Antimicrob Chemother2002，49，3： | 1 |
| 4 | Nurses' experiences with catas-trophic upper gastrointestinal bleeding in patients with hepatocellu-lar carcinoma: A qualitative study 显示文摘 | Zheng R Dong F Qiang W | 2013 | Eur J Oncol Nurs2013，17，4： | 1 |
| 5 | Early immune outcome of retroperitoneal laparoscopic radical nephrectomy for localized renal cell carcinoma:a prospective,randomized study显示文摘 | LU Y TIANYONG F QIANG W | 2012 | Can Urol Assoc J2012，6，6： | 1 |
| 6 | Residual Veterinary Antibiotics in Swine Manure From Concentrated Animal Feeding Operations in Shandong Province,China显示文摘 | PAN X QIANG Z BEN W | | 0，，04： | 1 |
| 7 | Variations of stomatal density and carbon isotope values of Picea crassifolia at different elevations in the Qilian mountains 显示文摘 | QIANG W Y WANG X N CHEN T | 2003 | Trees2003，17，3： | 1 |
| 8 | Simultaneous Determi- nation of Sulfonamides, Tetracyclines and Tiamulin in Swine Wastewater by Solid-Phase Extraction and Liquid Chromatography- Mass Spectrometry显示文摘 | BEN W W QIANG Z M ADAMS C | 2008 | Journal of Chromatography A2008，1202，2： | 1 |
| 9 | Thermophysicla proper- ties of complex rare-earth zirconate ceramic for thermal barrier coatings 显示文摘 | Ling L Qiang X Chi W F | 2008 | Journal of American Ceramic Society2008，，91： | 1 |
| 10 | Disposable microfluidic device with ultraviolet detection for highly resolved screening of illicit drugs显示文摘 | QIANG W ZHAI C LEI J | 2009 | Analyst2009，134，9： | 1 |
| 11 | Widening of the tropical belt in a changing climate显示文摘 | Seidel D J Fu Qiang Randel W J | 2008 | Nature Geoscience2008，，1： | 1 |
| 12 | Application of guard trace with vias in the RF PCB layout显示文摘 | Zhi L Qiang W | 2002 | Instrumentation and Electromag- netic Compatibility2002，41，2： | 1 |
| 13 | A randomized, controlled trial of postoperative adjuvant eytokine-indueed killer cells immunotherapy after radical resection of hepatocellular car- cinoma 显示文摘 | HUI D QIANG L JIAN W | 2009 | Dig Liver Dis2009，41，1： | 1 |
| 14 | Evaluation of the flavor-- noid oroxylin A as an inhibitor of P--glycoprotein--mediated cellular efflux-- 显示文摘 | Go W J Ryu J H Qiang F | 2009 | JNatProd2009，72，9： | 1 |
| 15 | Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients显示文摘 | Qiang L Hong L Ningfu W | 2013 | Int J Cardiol2013，168，3： | 1 |
| 16 | In the Eye of the Beholder: A Survey of Models for Eyes and Gaze 显示文摘 | Hansen D W Qiang Ji | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence (S0162-8828)2010，32，3： | 1 |
| 17 | Mechanical properties of short carbon fiber-reinforced TiC composites produced by hot pressing显示文摘 | GUIMING S QIANG L GUANGWU W | 2002 | Materials Science and Engineering2002，326，2： | 1 |
| 18 | The study on hand-arm vibra- tion syndrome in China显示文摘 | LIN W CHUNZHI Z QIANG Z | 2005 | Ind Health2005，43，3： | 1 |
| 19 | A randomized,controlled trial of post- operative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma显示文摘 | Hui D Qiang L Jian W | 2009 | Dig Liver Dis2009，41，1： | 1 |
| 20 | Knowledge-Based System for Railway Scheduling显示文摘 | QIANG T W Hau H Y | 1998 | Data & Knowledge Engineering1998，27，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员