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| 1 | 中国慢性病的挑战与应对显示文摘中国在短短几十年内,完成了从传染病向慢性病的流行病学模式转变,转变速度远远高于其他许多国家。而行为模式的转变,包括膳食习惯变化、体力活动减少、高水平的男性吸烟率等危险因素是中国疾病模式快速转变的重要原因。其结果是,这些本可避免的慢性病的发病率和死亡率快速上升。引发了医疗卫生服务费用显著上升。目前,中国有1.77亿高血压患者,有3.03亿烟民(占世界烟民的1/3),并有5.3亿人遭受被动吸烟危害。 | Gonghuan Yang Lingzhi Kong Wenhua Zhao Xia Wan Yi Zhai Lincoln C Chen Jeffrey P Koplan | 2008 | 世界临床医学2008，2，6： | 5 |
| 2 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 3 | NAD synthase nmnat acts as a chaperone to protect against neurodegeneration显示文摘 | Zhai R G Zhang F Hiesinger P R Cao Y Haueter C M Bellen H J | 2008 | Nature2008，452，： | 1 |
| 4 | The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population显示文摘 | ZHAI R LIU G YANG C | 2001 | Pharmacogenetics2001，11，： | 1 |
| 5 | Rverine input and air-sea C02 ex-changes near the Changjiang (Yangtze River) Estuary : Status quo andimplication on possible future changes in metabolic status显示文摘 | Chen C T A Zhai W D Dai M H | 2008 | ContientalShelf Research2008，28，： | 1 |
| 6 | CO2 absorption by alkaline soils and its implication to the global carbon cycle显示文摘 | Xie J X Li Y Zhai C X | 2009 | Environmen- tal Geology2009，56，： | 1 |
| 7 | Efficacy and safety of low dose recombinant tissuetypeplasminogen activator for the treatment of acute pulmonarythromboembolism: a randomized, multicenter, controlled trial显示文摘 | Wang C Zhai Z | 2010 | Chest2010，137，2： | 1 |
| 8 | A study of smoothing meth-ods for language models applied to information retrieval显示文摘 | ZHAI C X LAFFERTY J | 2004 | The SMART Retrieval System:Experiments in Au-tomatic Document Processing2004，22，2： | 1 |
| 9 | The IgA heavy-chain gene family in rabbit:cloning and sequence analysis of 13 C alpha genes显示文摘 | Burnett R C Hanly W C Zhai S K | 1989 | EMBO1989，8，13： | 1 |
| 10 | A study on EEG-Encephalofluctuographic characteristics in alpha frequency band in pilots显示文摘 | Zhou C Zhai Y Liu Y | 1998 | Space Med Med Eng1998，11，1： | 1 |
| 11 | The geological characteristics, tectonic settings and ages of ophiolite in Western Junggar, Xinjiang显示文摘 | Zhang C Huang X Zhai M G | 1995 | Collected Papers of Institute of Geology Chinese Academy of Sciences1995，8，： | 1 |
| 12 | Preoperative aspiration culture for preoperative diagnosis of infection in total hip or knee arthroplasty显示文摘 | Qu X Zhai Z Wu C | 2013 | J Clin Microbiol2013，51，11： | 1 |
| 13 | Corrosion behavior of pulse-plated Zn-Ni alloy coatings on AZ91 magnesium alloy in alkaline solutions 显示文摘 | Jiang Y F Liu L F Zhai C Q | 2005 | Thin Solid Films2005，484，： | 1 |
| 14 | The isolation and characterization of Pik,a rice blast resistance gene which emerged after rice domestication显示文摘 | Zhai C Lin F Dong Z Q | 2010 | New Phytologist2010，189，1： | 1 |
| 15 | Efficient plant regeneration from em- bryogenic suspension cultures of sweetpotato 显示文摘 | Liu Q C Zhai H Wang Y | 2001 | In Vitro Cellular and Developmental Biology - Plant2001，37，5： | 1 |
| 16 | Selective Inhibition of PI3 K/ Akt/mTOR Signaling Pathway Regulates Autophagy of Macro- phage and Vulnerability of Atherosclerotic Plaque 显示文摘 | Zhai C Cheng J Mujahid H | 2014 | PLoS One2014，9，90： | 1 |
| 17 | Preparation of mi- crocel显示文摘 | Zhai W T Leung S N Park C B | 2010 | Journal of Applied Polymer Science2010，116，： | 1 |
| 18 | Performance of opportunistic relaying with tnmcated ARQ over Nakagami-m fading channels显示文摘 | ZHAI C XU H LIU J | 2012 | European Transactions on Emerging Telecommunication Technologies2012，23，： | 1 |
| 19 | Efficacy and safety of low dose recombinant tissue-type plasminogen activator for the treatment of acute pulmonary thromboembolism : a randomized, multicenter,controlled tria显示文摘 | Wang C Zhai Z Yang Y | 2010 | Chest2010，137，2： | 1 |
| 20 | High viral load is associated with poor overall and recurrence-free survival of hepatitis B virus-related hepatocellular carcinoma after curative resection: a prospective cohort study显示文摘 | YANG T LU J H ZHAI J LIN C YANG G S ZHAO R H | 2012 | Eur J Surg Oncol2012，38，： | 1 |
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