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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | 冠状动脉内皮功能障碍患者循环MOTS-c水平下调显示文摘MOTS-c是一种新发现的线粒体衍生肽,其在调节代谢稳态中起作用。该研究旨在研究在没有显著冠状动脉结构性病变的患者中循环MOTS-c水平是否也与内皮功能障碍相关。方法:纳入无冠状动脉结构性病变的复发性心绞痛并接受冠状动脉造影和内皮功能检测的患者40例。 | Qin Q Delrio S Wan J Jay Widmer R Cohen P Lerman LO Lerman A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 14 |
| 3 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 4 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 5 | 东方蜜蜂高效的卫生行为机制对于西方蜜蜂抗病育种的启示显示文摘西方蜜蜂(Apismellifera)在世界各地大范围的蜂群损失现象已引起科学界和公众的广泛关注,其健康状况与东方蜜蜂(Apis cerana)相比明显较劣。东方蜜蜂群内可检测到的病原体和寄生虫相对较少,即它们对于生物威胁具有更强的抵抗力,即便是面对异种入侵的新病原(如蜜蜂残翅病毒)。 | Lin Z Page P Li L Qin Y Zhang Y Hu F Neumann P Zheng H Dietemann V 蔺哲广 郑火青 胡福良 | 2016 | 中国蜂业2016，67，12： | 5 |
| 6 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 7 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 8 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 9 | Performance and uncertainty analysis of a short-term climate reconstruction based on multi-source data in the Tianshan Mountains region,China显示文摘Short-term climate reconstruction,i.e.,the reproduction of short-term(several decades)historical climatic time series based on the relationship between observed data and available longer-term reference data in a certain area,can extend the length of climatic time series and offset the shortage of observations.This can be used to assess regional climate change over a much longer time scale.Based on monthly grid climate data from a Coupled Model Inter-comparison Project phase 5(CMIP5)dataset for the period of 1850–2000,the Climatic Research Unit(CRU)dataset for the period of 1901–2000 and the observed data from 53 meteorological stations located in the Tianshan Mountains region(TMR)of China during the period of 1961–2011,we calibrated and validated monthly average temperature(MAT)and monthly accumulated precipitation(MAP)in the TMR using the delta,physical scaling(SP)and artificial neural network(ANN)methods.Performance and uncertainty during the calibration(1971–1999)and verification(1961–1970)periods were assessed and compared using traditional performance indices and a revised set pair analysis(RSPA)method.The calibration and verification processes were subjected to various sources of uncertainty due to the influence of different reconstructed variables,different data sources,and/or different methods used.According to traditional performance indices,both the CRU and CMIP5 datasets resulted in satisfactory calibrated and verified MAT time series at 53 meteorological stations and MAP time series at 20 meteorological stations using the delta and SP methods for the period of 1961–1999.However,the results differed from those obtained by the RSPA method.This showed that the CRU dataset produced a low degree of uncertainty(positive connection degree)during the calibration and verification of MAT using the delta and SP methods compared to the CMIP5 dataset.Overall,the calibrated and verified MAP had a high degree of uncertainty(negative connection degree)regardless of the dataset or reconstruction method used.Therefore,the reconstructed time series of MAT for the period of 1850(or 1901)–1960 based on the CRU and CMIP5 datasets using the delta and SP methods could be used for further study.The results of this study will be useful for short-term(several decades)regional climate reconstruction and longer-term(100 a or more)assessments of regional climate change. | LI Xuemei Slobodan P SIMONOVIC LI Lanhai ZHANG Xueting QIN Qirui | 2020 | Journal of Arid Land2020，12，3： | 2 |
| 10 | Study of the adsorption behavior of heavy metal ions on nanometer-size titanium dioxide with ICP-AES显示文摘 | QIN Y C HU B | 2000 | FreseniusJ Anal Chem2000，368，： | 1 |
| 11 | Isolation and expression analysis of fructokinase genes from Citrus显示文摘 | Qin Q P Zhang S L Chen J W | 2004 | Acta Botanica Sinica2004，46，12： | 1 |
| 12 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 13 | Circulating pregnancy- associated plasma protein a predicts outcome in patients with acute coronary syndrome but no troponin I elevation 显示文摘 | Lurid J Qin Q P llva T Pettersson K | 2003 | Circulation2003，108，16： | 1 |
| 14 | Re verse signaling using an inducible costimulator to enhance im munogenic function of dendritic cells显示文摘 | Tang G Qin Q Zhang P Wang G Liu M Ding Q | 2009 | Ceil Mol Life Sci2009，66，： | 1 |
| 15 | Polyelectrolytes as in- clusions in electrorheologically active materials: Effect of chemical characteristics on ER actirity materials and mecha- nisms in electrorheology显示文摘 | BLOCK H KELLY J P QIN A | 1990 | Langmuir1990，6，： | 1 |
| 16 | Evolutionary extreme learning machine显示文摘 | Q Zhu A k Qin P Suganthan | 2005 | Pattern Recognition2005，38，： | 1 |
| 17 | A mono-window algorithm for retrieving land surface temperature from Landsat TM data and its application to the Israel-Egypt border region显示文摘 | Qin Z Karnicli A Berliner P | 2001 | Int J Remote Sens Environ2001，22，18： | 1 |
| 18 | Retinoic acid receptors and cancers 显示文摘 | Soprano DR Qin P Soprano KJ | 2004 | Annu RevNutr2004，24，： | 1 |
| 19 | Mismatch negativity to the patient's own name in chronic disorders of consciousness显示文摘 | Qin P Di H Yan X | 2008 | Neurosci Lett2008，448，1： | 1 |
| 20 | The a-chemokine, stromal cell-derived fac- tor-la, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduc- tion pathways显示文摘 | Ganju R K Brubaker S A Meyer J Dutt P Yang Y Qin S | 1998 | J Biol Chem1998，273，23： | 1 |
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