|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis(NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH. An immune response is triggered by countless signals called damage-associated molecular patterns(DAMPs) elicited by lipid-laden and damaged hepatocytes, which are recognized by pattern recognition receptors(PRRs) on hepatic immune cells to initiate inflammatory signaling. In this editorial, in addition to summarizing innate immune signaling in NAFLD and discussing potential therapies that target innate immune pathways, we have described a recent study that demonstrated that mitochondrial DNA serves as a DAMP activating a hepatic PRR, TLR9, in mice and in the plasma of NASH patients. In addition to identifying a new ligand for TLR9 during NASH progression, the study shows that blocking TLR9 reverses NASH, paving the way for the development of future NASH therapy. | Priya Handa Akhila Vemulakonda Kris V Kowdley Misael Uribe Nahum Méndez-Sánchez | 2016 | World Journal of Gastroenterology2016，22，31： | 3 |
| 2 | Lewis acid metal ion-exchanged MAPO-5 molecular sieves for solvent free synthesis of coumarin derivative显示文摘 | GOPALAKRISHNAN S VISWANATHAN K R PRIYA S V MABEL J H PALANICHAMY M MURUGESAN V | 2008 | Catalysis Communications2008，10，10： | 1 |
| 3 | Postpartum hemorrhage : evi- dence-based medical interventions for prevention and treatment显示文摘 | Rajan Priya V Deborah A | 2010 | Clin Obstet Gynecol2010，53，1： | 1 |
| 4 | Simuhaneous bioconversion of cel- lulose and hemicellulose to ethanol显示文摘 | Priya Chandrakant Bisaria V S | 1998 | Critical Reviews in Biotechnology1998，18，4： | 1 |
| 5 | Association of interleukin-10 gene promoter poIy- morphism in allergic patients显示文摘 | GADDAM S L PRIYA V H S BABU B M V S | 2012 | Genet Test Mol Bi- omarkers2012，16，： | 1 |
| 6 | Growth Feed Utilization and Apparent Digestibility of Common Carp Cyprinus Carpio Var Communis Using Amylase Enzyme显示文摘 | Rajan M R Priya V | 1999 | Environment and Ecology1999，17，3： | 1 |
| 7 | Effect of hydrophobic and hydrophilic properties of solid acid catalysts on the esterification of mateic anhydride with ethanol显示文摘 | Bhagiyalakshmi M Priya S V Mabel J H | 2008 | Catalysis Communications2008，9，10： | 1 |
| 8 | Dark solitons,breathers,and rogue wave solutions of the coupled generalized nonlinear Schrdinger equations显示文摘 | Priya N V Senthilvelan M Lakshmanan M | 2014 | Phys Rev E2014，89，06： | 1 |
| 9 | Recovery and reuse of Ni (Ⅱ) from rinsewater of electroplating indus- tries 显示文摘 | Priya R G Basha C A Ramamurthi V | 2009 | Journal of Hazardous Materials2009，163，： | 1 |
| 10 | Low-temperature spin dynamics of doped manganites: Roles of Mn t2g, Mn eg, and O 2p states 显示文摘 | MAHADEVAN Priya SOLOVYEV I V TERAKURA K | 1999 | Phys Rev1999，60，11： | 1 |
| 11 | Effect of the magne tostrictive layer on magnetoelectric properties in lead zirconate titanate/Terfennol-D laminate composites显示文摘 | Ryu J Priya S Carazo A V Uchino K | | J Am Cera Soc0，84，： | 1 |
| 12 | Abnormal circadian rhythm and cortisol excretion in autistic children: a clinical study显示文摘 | Lakshmi Priya MD Geetha A Suganya V | 2013 | Croat Med J2013，54，1： | 1 |
| 13 | Postpartum hemorrhage:evidencebased medical intervetions for prevetion and treatment显示文摘 | Priya V Deborah A | 2010 | Clin Obstet Gynecol2010，53，1： | 1 |
| 14 | Optimization of ultrasoundassistedextraction of natural pigments from Bougainvillea glabraflowers 显示文摘 | Maran J P Priya B Nivetha C V | 2015 | Industrial Crops and Products2015，63，18： | 1 |
| 15 | Solvent extraction of Zr(Ⅳ) from acidic chloride solution using 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (PC-88A) 显示文摘 | Reddy B R Kumar J R Reddy A V Priya D N | 2004 | Hydrometallurgy2004，72，： | 1 |
| 16 | Postpartum hemonhage:evidenee-based medical interventions for prevention and treatment显示文摘 | Priya V Deborah A | 2010 | Clin Obstet Gynecol2010，53，1： | 1 |
| 17 | Solvent extraction of zireonium(Ⅳ) from acidic chloride solutions using 2- ethyl hexyl phosphonie acid mono-2-ethyl hexyl ester ( PC-88A ) 显示文摘 | Reddy B R Kumar J R Reddy A V Priya D N | 2004 | Hydrometallurgy2004，72，： | 1 |
| 18 | FPGA- based fuzzy logic controller for electric vehicle 显示文摘 | Poorani S Urmila Priya T V S Kumar K U | 2005 | The Institution of En- gineers2005，45，5： | 1 |
| 19 | Postpartum Hemorrhage:Evidence-based medical interventions for prevention and treatment显示文摘 | Priya V Deborah A | 2010 | Clin obstet Gynecol2010，1，53： | 1 |
| 20 | Postpartum hemorrhage:evidence-based medical interventions for prevention and treatment显示文摘 | Priya V Deborah A | 2010 | Clin Obstet&Gynecol2010，53，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员