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| 1 | Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study显示文摘AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) patients.METHODS This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also analysed.RESULTS A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Both treaments showed acceptable safety profiles. The telbivudine arm showed e GFR improvement unlike the tenofovir arm.CONCLUSION Efficacy was shown for both telbivudine-roadmap and tenofovir-roadmap regimens in HBe Ag-negative CHB patients over 156 wk. Telbivudine arm was associated with renal improvement. | Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra Priti Pandey Kamal Hamed | 2016 | World Journal of Hepatology2016，8，32： | 9 |
| 2 | Biomedical Perspective of Electrochemical Nanobiosensor显示文摘Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed. | Priti Singh Shailendra Kumar Pandey Jyoti Singh Sameer Srivastava Sadhana Sachan Sunil Kumar Singh | 2016 | Nano-Micro Letters2016，8，3： | 5 |
| 3 | Saponin synthesis and cotton growth is antagonistically regulated by solar UV-B radiation显示文摘Background: Earlier we have reported that the exclusion of solar UV-B increased the growth and yield of cotton plants as compared with ambient UV-B. The UV-B radiation effects on the saponins and the impact of ambient and reduced UV-B on the accumulation of saponins has not been investigated yet. Thus a field experiment was conducted to study the influence of solar UV-B on the growth response and saponin synthesis in cotton(Gossypium hirsutum) var. Vikram plants by the exclusion of UV-B. The cotton plants were grown in specially designed iron chambers, wrapped with filters that excluded UV-B(<315 nm), or transmitted ambient UV-B.Results: Exclusion of ambient UV-B enhanced the growth of cotton plants in terms of plant height and leaf area.Greater plant height in UV-B excluded plants was due to elongated internode and more number of nodes.Enhancement in growth was accompanied by a decrease in the accumulation of saponins, which was quantified by the spectrophotometric, TLC and HPLC methods. Solvent extraction of saponins from the internodes and leaves were used for the bioassay of Amaranthus hypocotyl growth and expansion of cucumber cotyledons. Extracts obtained from the UV-B excluded plants(leaves and internodes) promoted the growth to a larger extent as compared with the extracts obtained from ambient grown plants.Conclusions: The result indicates that solar UV-B may possibly suppress the plant growth by regulating the synthesis of natural growth inhibitor's like saponin. | DEHARIYA Priti KATARIA Sunita GURUPRASAD Kadur Narayan PANDEY Govind Prakash | 2018 | Journal of Cotton Research2018，1，3： | 1 |
| 4 | Targeted novel surface-modified nanoparticles for interferon delivery for the treatment of hepatitis B显示文摘现在的工作的目的是开发肝炎 B 表面抗原(HBsAg ) 吸附表面的 cationic poly (d, l-lactic-co-glycolic 酸) 为干扰素 alpha (IFN ) 的 PLGA nanoparticles 指向到 hepatocytes 的交货。与 IFN 装载的 Cationic PLGA nanoparticles 用双乳化技术被准备。Delipidated HBsAg 被使用简单蘸并且弄干的方法消极地在 nanoparticles 的表面上吸附。nanoparticles 的表面形态学和尺寸分发被分别地扫描电子显微镜学和动态轻散布的方法分析。平凡、 HBsAg 涂的 99mTc 标签 PLGA nanoparticles 的 biodistribution 行为也被检验由静脉内的注射列在后面。结果表明 75% 放射性在比平凡 PLGA nanoparticles 是将近在大小更大的 3 褶层的注射的 4 h 以后在肝被恢复。这些数据证明 nanoparticles 的新奇明确的表达在肝目标的药交货有潜在的申请。 | Namita Giri Priti Tomar Vijai Singh Karwasam Ravi S. Pandey V.K. Dixit | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 1 |
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