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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Carbothermal synthesis of vanadium and chromium carbides from solution derived precursors 显示文摘 | Preiss H Schultzeb D Szulzewsky K | 1999 | J Eur Ceram Soc1999，19，2： | 1 |
| 3 | A new device for endovascular coil retrieval from intracranial vessels:alligator retrieval device显示文摘 | Henkes H Lowens S Preiss H | 2006 | AJNR2006，27，： | 1 |
| 4 | Cholesterol and coronary heart disease:predicting risks by levels and ratios显示文摘 | Kinosian B Glick H Preiss L | 1995 | J Investig Med1995，43，5： | 1 |
| 5 | Preparation of molybdenum and tungsten carbides from solution derived precursors显示文摘 | Preiss H Meyer B Olschewski C | 1998 | Journal of Materials Science1998，33，3： | 1 |
| 6 | Serum interleukin-6 levels in colorectal cancer patients--a summary of published results显示文摘 | KNUPFER H PREISS R | 2010 | Int J Colorectal Dis2010，25，2： | 1 |
| 7 | Thermal treatment of binary carbonaceous/zirconia gels and formation of Zr(C,O,N) solid solutions显示文摘 | Preiss H Berger LM Szulzewsky K | 1996 | Carbon1996，34，1： | 1 |
| 8 | Synthesis of Polymeric Titanium and Zirconium Precursors and Preparation of Carbide Fibers and Films显示文摘 | Preiss H Schierhorn E Brzezinka K W | 1998 | Journal of Materials Science1998，33，19： | 1 |
| 9 | Expression of branching enzyme of maize endosperm in Escherichia coli显示文摘 | Guan H P Baba T Preiss J | 1994 | Plant physiology1994，104，4： | 1 |
| 10 | Formation of black glasses and silicon carbide from binary carbonaceous/silica hydrogels 显示文摘 | Preiss H Berger L M Braum M | 1995 | Carbon1995，33，12： | 1 |
| 11 | Formation of NbC and TaC from gel-derived precursors 显示文摘 | PREISS H SCHULTZE D KLOBES P | 1997 | J Eur Ceram Soc1997，17，12： | 1 |
| 12 | Preparation of carbon cata-lysts by hydrothermal treatment of a carbonaceous hydrogel显示文摘 | Preiss H Lischke G Eckeit R | 1994 | Carbon1994，32，4： | 1 |
| 13 | Studies on the Carbothermal Preparation of Titanium Carbide from Different Gel Precursors显示文摘 | Preiss H Berger L M Schultze D | 1999 | Journal of the European Ceramic Society1999，19，2： | 1 |
| 14 | Pi:A practical incentive protocol for delay tolerant networks显示文摘 | Lu R Lin X Zhu H Shen X and Preiss B | 2010 | IEEE Trans on Wireless Communications2010，9，14： | 1 |
| 15 | Formation of NbC and TaC from Gel-Derived Precursors显示文摘 | Preiss H Schultze D Klobes P | 1997 | Journal of the European Ceramic Society1997，17，12： | 1 |
| 16 | Significance of interleukin-6 (IL-6) in breast cancer显示文摘 | Knupfer H Preiss R | 2007 | Breast Cancer Res Treat2007，102，2： | 1 |
| 17 | Differentiation of the properties of the starch branching isozymes from maize (Zea mays) 显示文摘 | Guan H P Preiss J | 1993 | Plant Physiology1993，102，4： | 1 |
| 18 | The major proteins of wheat endosperm starch granules显示文摘 | Rahman S Kosar-Hashemi B Samuel M S Hill A Abbott D C Skerritt J H Preiss J Appels R M | | 0，，： | 1 |
| 19 | Branching of amylose by the branching isoenzymes of maize endosperm显示文摘 | Takeda Y Guan H P Preiss J | 1993 | Carbohydrate Research1993，240，1： | 1 |
| 20 | Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios 显示文摘 | Kinosian B Gliek H Preiss L | 1995 | J Investig Med1995，43，5： | 1 |
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