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| 1 | 1α,25-dihydroxyvitamin D_(3) prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital显示文摘AIM:To investigate the chemopreventive iffects of 1α,25-dihydroxyvitamin D3 in diethylnitrosamine induced,phenobarbital promoted rat hepatocarcinogenesis.METHODS:The rats were randomly divided into 6 different groups(A-F).Group A,C and E rats received a single intraperitoneal (i.p) injection of diethylnitrosamine (DEN) at a dose of 200 mg/kg body mass in 9 g/L NaCl solution at 4 wk of age ,while group B served as normal vehicle control received normal saline once.After a brief recovery of 2 WK, all the DEN treated rats were given phenobarbital (PB) at 0.5g/L daily in the basal diet till WK 20.Group C was started 4 wk prior to DEN injection and continued thereafter till wk 20 at a dose (os) twice a week.Group E received the treatment of 1α,25-(OH)2D3 at the same dose mentioned as above for 15 wk.The rats in group D and F received 1α,25-(OH)2D3 alone as in group C without DEN injection.RESULTS:The comet assay showed statistically higher mean values for length to width ratios (L:W) of DNA mass and tailed cells (p<0.01;p<0.01 respectively) in DEN treated rats as compared to their normal controls.Continuous supplementation of 1α,25-dihydroxyvitaminD3 showed a significant (p<0.01) decrease in L:W ratio of DNA mass tailed cells.Furthermore,1α,25-(OH)2D3 supplementations elevated the super oxide dismutase (SOD) activety,hepatic malondialdehyde(MDA) levle,reduced glutathione (GSH) and glutathione S-transferase (GST) activety (p<0.01,p<0.01,p<0.05 and p<0.05 respectively).As an endpoint marker histological changes were observed to establish the chemopreventive effects of 1α,25-dihydroxyvitaminD3.CONCLUSION:Supplementations of 1α,25-(OH)2D3 has a marked protection against hepatic nodelogenesis,antioxidant enzymes and DNA damages in DEN induced rat hepatocarcinogenesis promoted by phenobarbital. | Mahendrakumar Chandrasekharappa Banakar Suresh Kanna Paramasivan Mitali Basu Chattopadhyay Subrata Datta Prabir Chakraborty Malay Chatterjee Kalaiselvi Kannan Elayaraja Thygarajan | 2004 | World Journal of Gastroenterology2004，10，9： | 5 |
| 2 | An experimental and theoretical investigation on torrefaction of a large wet wood particle显示文摘 | Prabir Basu Anup Kumar Sadhukhan Parthapratim Gupta | 2014 | Bioresource Technology2014，159，2： | 1 |
| 3 | Methods to derive seismic fragility of NPP components: A summary显示文摘 | Ajai S. Pisharady Prabir C. Basu | 2010 | Nuclear Engineering and Design2010，，11： | 1 |
| 4 | Curing of high performance concrete:Indian experience显示文摘 | Prabir C Basu | 1999 | The Indian Concrete Journal1999，3，： | 1 |
| 5 | An experimental investigation into the heat transfer on wing walls in a circulating fluidized bed boiler显示文摘 | Animesh Dutta Prabir Basu | 2002 | International Journal of Heat and Mass Transfer2002，45，18： | 1 |
| 6 | Experimental investigation into the hydrodynamics of flow of solids through a loop seal recycle chamber显示文摘 | Botsio Eugene Basu Prabir | 2005 | Canadian Journal of Chemical Engineering2005，83，3： | 1 |
| 7 | Reduction of calcium sulfate in a coal-fired circulating fluidized bed furnace显示文摘 | Jib Talukar Prabir Basu | | Fuel0，75，9： | 1 |
| 8 | Studies on the operation of loop-seal in circulating fluidized bed boilers 显示文摘 | Basu Prabir Butler James | 2009 | Applied Energy2009，86，： | 1 |
| 9 | Curing of high performance concrete: Indian experience 显示文摘 | Prabir C Basu | 1993 | The Indian Concrete Journal1993，3，： | 1 |
| 10 | Effect of pressure on loop seal operation for a pressurized circulating fluidized bed显示文摘 | Cheng Leming Basu Prabir | 1999 | Powder Technology1999，103，3： | 1 |
| 11 | Quantified gene expression levels for phase Ⅰ/Ⅱ metabolizing enzyme and estrogen receptor levels in benign prostate from cohorts designated as high-risk (UK) versus low-risk (India)for adenocarcinoma at this organ site:a preliminary study显示文摘 | Paras B. Singh Narasimhan Ragavan Katherine M. Ashton Prabir Basu Sayeed M. Nadeem Caroline M. Nicholson R. K. Gopala Krishna Shyam S. Matanhelia Francis L. Martin | 2010 | Asian Journal of Andrology2010，12，2： | 1 |
| 12 | Reduction of calcium sulfate in a coal-fired circulating fluidized bed furnace显示文摘 | Jib Talukdar Prabir Basu Jay H Greenblatt | 1996 | fuel1996，75，9： | 1 |
| 13 | Reduction of calcium sulfate in a coal-fired circulating fluidized bed furnace显示文摘 | Jib Talukdar Prabir Basu Jay H Greenblatt | 1996 | Fuel1996，75，9： | 1 |
| 14 | Reduction of Calcium Sulfate in a Coal-fired Circulatinf Fluidized Bed Furnace 显示文摘 | JIB TALUKDAR PRABIR BASU GREENBLATT H | 1996 | Fuel1996，75，9： | 1 |
| 15 | Effect of pressure on loop seal operation for a pressurized circulating fluidized bed显示文摘 | Prabir Basu | 1999 | Powder Technology1999，103，3： | 1 |
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