|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Occult hepatitis B virus and hepatocellular carcinoma显示文摘Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several decades.By definition,OBI is characterized by the persistence of HBV DNA in the liver tissue(and in some cases also in the serum)in the absence of circulating HBV surface antigen(HBsAg).Many epidemiological and molecular studies have indicated that OBI is an important risk factor for hepatocellular carcinoma(HCC)development.OBI may exert direct pro-oncogenic effects through the activation of the same oncogenic mechanisms that are activated in the course of an HBsAg-positive infection.Indeed,in OBI as in HBV-positive infection,HBV DNA can persist in the hepatocytes both integrated into the host genome as well as free episome,and may maintain the capacity to produce proteins-mainly X protein and truncated preS-S protein-provided with potential transforming properties.Furthermore,OBI may indirectly favor HCC development.It has been shown that the persistence of very low viral replicative activity during OBI may induce mild liver necro-inflammation continuing for life,and substantial clinical evidence indicates that OBI canaccelerate the progression of liver disease towards cirrhosis that is considered the most important risk factor for HCC development. | Teresa Pollicino Carlo Saitta | 2014 | World Journal of Gastroenterology2014，20，20： | 13 |
| 2 | Control of cccDNA function in hepatitis B virus infection显示文摘 | Massimo Levrero Teresa Pollicino Jorg Petersen Laura Belloni Giovanni Raimondo Maura Dandri | 2009 | Journal of Hepatology2009，，3： | 8 |
| 3 | Role natural killer group 2D-ligand interactions in hepatitis B infection显示文摘Hepatitis B virus(HBV) infection is the leading cause of liver disease and hepatocellular carcinoma(HCC) worldwide, in spite of prophylactic vaccination and antiviral treatment modalities. The immunopathogenesis of HBV infection has been intensively studied and ispropelled by complex interactions between the virus and the host immune system. Natural killer group 2D(NKG2D) is a well-characterized activating receptor, expressed on natural killer(NK) cells, NK T cells and CD8+ cytotoxic T cells. This receptor is present in both humans and mice and binds to a diverge family of ligands that resemble the MHC-class?Ⅰ?molecules. Increasing evidence shows that NKG2D-ligand interactions are critical in the establishment of HBV persistence and the development of liver injury and HCC. The expression of NKG2 D ligands depends on the presence of several polymorphisms and is also modulated post-transcriptionally by HBV. While it is known that HBV circumvents host's innate immunity via the NKG2 D pathway but the exact mechanisms involved are still elusive. This letter discusses previous accomplishments on the role of NKG2 D ligand regulation in the development of chronic HBV, liver injury and HCC. | Teresa Pollicino Lemonica Koumbi | 2015 | World Journal of Hepatology2015，7，6： | 5 |
| 4 | Occult HBV infection显示文摘 | Giovanni Raimondo Gaia Caccamo Roberto Filomia Teresa Pollicino | 2013 | Seminars in Immunopathology2013，，1： | 4 |
| 5 | Occult hepatitis B virus infection显示文摘 | Giovanni Raimondo Teresa Pollicino Irene Cacciola Giovanni Squadrito | 2006 | Journal of Hepatology2006，，1： | 3 |
| 6 | Hepatitis B virus PreS/S gene variants: Pathobiology and clinical implications显示文摘 | Teresa Pollicino Irene Cacciola Francesca Saffioti Giovanni Raimondo | 2014 | Journal of Hepatology2014，，： | 3 |
| 7 | IFN-[alpha] inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome显示文摘 | Belloni Laura Allweiss Lena Guerrieri Francesca Pediconi Natalia Volz Tassilo Pollicino Teresa Petersen Joerg Raimondo Giovanni Dandri Maura Levrero Massimo | 2012 | EN2012，，2： | 2 |
| 8 | Occult hepatitis B virus in liver tissue of individuals without hepatic disease显示文摘 | Giovanni Raimondo Giuseppe Navarra Stefania Mondello Lucy Costantino Guido Colloredo Eugenio Cucinotta Gaetano Di Vita Claudio Scisca Giovanni Squadrito Teresa Pollicino | 2008 | Journal of Hepatology2008，，5： | 2 |
| 9 | Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways显示文摘 | Cecilia Scisciani Stefania Vossio Francesca Guerrieri Valeria Schinzari Rossana De Iaco Paolo D’Onorio de Meo Melchiorre Cervello Giuseppe Montalto Teresa Pollicino Giovanni Raimondo Massimo Levrero Natalia Pediconi | 2011 | Journal of Hepatology2011，，4： | 2 |
| 10 | Hepatitis B Virus Replication Is Regulated by the Acetylation Status of Hepatitis B Virus cccDNA-Bound H3 and H4 Histones显示文摘 | Teresa Pollicino Laura Belloni Giuseppina Raffa Natalia Pediconi Giovanni Squadrito Giovanni Raimondo Massimo Levrero | 2006 | Gastroenterology2006，，3： | 2 |
| 11 | Impact of occult hepatitis B virus infection on the outcome of chronic hepatitis C显示文摘 | Giovanni Squadrito Irene Cacciola Angela Alibrandi Teresa Pollicino Giovanni Raimondo | 2013 | Journal of Hepatology2013，，： | 2 |
| 12 | Control of eecDNA function in hepatitis B virus infection显示文摘 | Levrero M Pollicino T Petersen J | 2009 | J Hepatol2009，51，3： | 1 |
| 13 | Hepatitis B virus maintains its pro-oncogenic propetries in the case of occult HBV infection 显示文摘 | Pollicino T Squadrito G Cerenzia G | 2004 | Gastroentherology2004，126，1： | 1 |
| 14 | Genomic heterogeneity of hepatitis B virus (HBV) and out come of pednatal HBV infection显示文摘 | Cacciold Ccrenzia G Pollicino T ct al | 2002 | J Hepatol2002，36，3： | 1 |
| 15 | Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones显示文摘 | Pollicino T Belloni L Raffa G | | 0，，03： | 1 |
| 16 | Control of cccDNA function in hepatitis B virus infection显示文摘 | Levrero M Pollicino T Petersen J | | 0，，： | 1 |
| 17 | Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones显示文摘 | Pollicino T Belloni L Raffa G | | 0，，： | 1 |
| 18 | Control of cccDNA function in hepatitis B virus infection显示文摘 | Levrero M Pollicino T Petersen J Belloni L Raimondo G Dandri M | | Journal of Hepatology0，，： | 1 |
| 19 | Oecult hepatitis B virus infeetion显示文摘 | Raimondo G Pollicino T Cacciola I | | J Hepatol0，46，16： | 1 |
| 20 | Properties of films obtained by UV-curing 4,4'hexafluoroisopropylidenediphenoldihydroxyethyiether diacrylate and its mixtures with the hydrogenated homolog显示文摘 | Bongiovanni R Malucelli G Pollicino A | 1998 | J Appl Polym Sci1998，63，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员