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| 1 | Helicobacter pylori virulence genes显示文摘Helicobacter pylori(H.pylori)is one of the most important human pathogens,infecting approximately half of the global population.Despite its high prevalence,only a subset of H.pylori infected individuals develop serious gastroduodenal pathology.The pathogenesis of H.pylori infection and disease outcome is thus thought to be mediated by an intricate interplay between host,environmental and bacterial virulence factors.H.pylori has adapted to the harsh milieu of the human stomach through possession of various virulence genes that enable survival of the bacteria in the acidic environment,movement towards the gastric epithelium,and attachment to gastric epithelial cells.These virulence factors enable successful colonization of the gastric mucosa and sustain persistent H.pylori infection,causing chronic inflammation and tissue damage,which may eventually lead to the development of peptic ulcers and gastric cancer.Numerous studies have focused on the prevalence and role of putative H.pylori virulence genes in disease pathogenesis.While several virulence factors with various functions have been identified,disease associations appear to be less evident,especially among different study populations.This review presents key findings on the most important H.pylori virulence genes,including several bacterial adhesins and toxins,in children and adults,and focuses on their prevalence,clinical significance and potential relationships. | Anja Sterbenc Erika Jarc Mario Poljak Matjaz Homan | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 2 | Human papillomavirus infection in esophageal carcinomas: A study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review显示文摘 | Mario Poljak Anton Cerar Katja Seme | 1998 | Human Pathology1998，，3： | 2 |
| 3 | Evidence Regarding Human Papillomavirus Testing in Secondary Prevention of Cervical Cancer显示文摘 | Marc Arbyn Guglielmo Ronco Ahti Anttila Chris J.L.M. Meijer Mario Poljak Gina Ogilvie George Koliopoulos Pontus Naucler Rengaswamy Sankaranarayanan Julian Peto | 2012 | Vaccine2012，，： | 2 |
| 4 | Results of National Colorectal Cancer Screening Program in Croatia(2007-2011)显示文摘AIM:To study the epidemiologic indicators of uptake and characteristic colonoscopic findings in the Croatian National Colorectal Cancer Screening Program.METHODS:Colorectal cancer(CRC) was the second leading cause of cancer mortality in men(n = 1063,49.77/100 000),as well as women(n = 803,34.89/100 000) in Croatia in 2009.The Croatian National CRC Screening Program was established by the Ministry of Health and Social Welfare,and its implementation started in September,2007.The coordinators were recruited in each county institute of public health with an obligation to provide fecal occult blood testing(FOBT) to the participants,followed by colonoscopy in all positive cases.The FOBT was performed by hypersensitive guaiac-based Hemognost card test(Biognost,Zagreb).The test and short questionnaire were delivered to the home addresses of all citizens aged 50-74 years consecutively during a 3-year period.Each participant was required to complete the questionnaire and send it together with the stool specimen on three test cards back to the institute for further analysis.About 4% FOBT positive cases are expected in normal risk populations.A descriptive analysis was performed.RESULTS:A total of 1 056 694 individuals(born between 1933-1945 and 1952-1957) were invited to screening by the end of September 2011.In total,210 239(19.9%) persons returned the envelope with a completed questionnaire,and 181 102 of them returned it with a correctly placed stool specimen on FOBT cards.Until now,12 477(6.9%),FOBT-positive patients have been found,which is at the upper limit of the expected values in European Guidelines for Quality Assurance in CRC Screening and Diagnosis [European Union(EU) Guidelines].Colonoscopy was performed in 8541 cases(uptake 66%).Screening has identified CRC in 472 patients(5.5% of colonoscopied,3.8% of FOBT-positive,and 0.26% of all screened individuals).This is also in the expected range according to EU Guidelines.Polyps were found and removed in 3329(39% of colonoscopied) patients.The largest number of polyps were found in the left half of the colon:64%(19%,37% and 8% in the rectum,sigma,and descendens,respectively).The other 36% were detected in the proximal part(17% in the transverse colon and 19% in ceco-ascending colon).Small polyps in the rectum(5-10 mm in diameter),sigmoid and descending colon were histologically found to be tubular adenomas in 60% of cases,with a low degree of dysplasia,and 40% were classified as hyperplastic.Polyps of this size in the transverse or ceco-ascending colon in almost 20% had a histologically villous component,but still had a low degree of dysplasia.Polyps sized 10-20 mm in diameter were in 43% cases tubulovillous,and among them,32% had areas with a high degree of dysplasia,especially those polyps in the cecoascending or transverse part.The characteristics of the Croatian CRC Screening National Program in the first 3 years were as follows:relatively low percentage of returned FOBT,higher number of FOBT-positive persons but still in the range for population-based programs,and higher number of pathologic findings(polyps and cancers).CONCLUSION:These results suggest a need for intervention strategies that include organizational changes and educational activities to improve awareness of CRC screening usefulness and increase participation rates. | Miroslava Katii Nataa Antoljak Milan Kujundzi Valerija Stameni Dunja Skoko Poljak Danica Kramari Davor timac Marija Strnad Peikan Mirko amija Zdravko Ebling | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 5 | Iodine intake and epidemio- logical characteristics of thyroid cancer: comparison between inland and littoral Croatia显示文摘 | Poljak NK Kontic M Colovic Z | 2011 | Acta Clin Croat2011，50，： | 1 |
| 6 | Progress with gene- Product mapping of the Mollicutes: Mycoplasma genitalium显示文摘 | Wasinger VC Cordwell S J Cerpa - Poljak A | 1995 | Electrophoresis1995，16，7： | 1 |
| 7 | Prevalence of the Helicobacter pylori babA2 gene and correlation with the degree of gastritis in infected Slovenian children显示文摘 | Matja? Homan Anja ?terbenc Bo?tjan J. Kocjan Bo?tjan Luzar Nina Zidar Rok Orel Mario Poljak | 2014 | Antonie van Leeuwenhoek2014，，4： | 1 |
| 8 | Clinical validation of the Abbott RealTime High Risk HPV assay according to the guidelines for humanpapillomavirus DNA test requirements for cervical screening显示文摘 | Hesselink AT Meijer CJ Poljak M | | 0，，7： | 1 |
| 9 | Progress with gene-product mapping of the Mollicutes:Mycoplasma genitalium显示文摘 | WASINGER V C CORDWELL S J CERPA POLJAK A | 1995 | Electrophoresis1995，16，7： | 1 |
| 10 | Acute fatty liver of pregnancy - an underlying condition for herpes simplex type 2 fulminant hepatitis necessitating liver transplantation 显示文摘 | Luzar B Ferlan-Marolt V Poljak M et al | 2005 | Z Gastroenterol2005，43，5： | 1 |
| 11 | As, Cd, Hg and Pb in four edible shellfish species from breeding and harvesting areas along the eastern adriatic coast, croatia显示文摘 | Bogdanovi?T Ujevi?I Sedak M Liste? E ?imat V Petri?evic? S Poljak V | 2014 | Food Chemistry2014，146，3： | 1 |
| 12 | Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture显示文摘 | Franzoso G Carlson L Poljak L | 1998 | J Exp Med1998，187，2： | 1 |
| 13 | Quantitative measure men of telomerase catalytic subunit (hTERT) mRNA in laryngeal squamous cell carcinomas显示文摘 | Luzar B Poljak M Marin IJ | 2001 | Anticancer Res2001，21，6： | 1 |
| 14 | Chromosome 7,17polysomies and overexpression of epidermal growth factor receptor and p53 protein in epithelial hyperplastic laryngeal lesions显示文摘 | Gale N Kambic V Poljak M | 2000 | Oncology2000，58，2： | 1 |
| 15 | Hybrid Capture II HPV Test detects at least 15 human papillomavirus genotypes not included in its current high-risk probe cocktail显示文摘 | Poljak M Marin IJ Seme K | 2002 | J Chn Virol2002，25，3： | 1 |
| 16 | Human papillomavirus infection in esophageal carcinomas: a study of 121 lesions using multiple broad -spectrum polymerase chain reactions and literature review显示文摘 | Poljak M Cerar A Seme K | 1998 | Hum Pathol1998，29，3： | 1 |
| 17 | Analysis of cotton (Gossypium hirsutum) root proteomes during a compatible interaction with the black root rot fungus Thielaviopsis basicola显示文摘 | COUMANS J V POLJAK A RAFTERY M J | 2009 | Proteomics2009，9，： | 1 |
| 18 | Telomerase reactivation is an early event in laryngeal carcinogenesis 显示文摘 | Luzar B Poljak M Marin IJ | 2003 | Mod Pathol2003，16，9： | 1 |
| 19 | Analysis of NCp7-dependent activation of HIV-1 eDNA integration and its conservation among retroviral nueleocapsid proteins显示文摘 | POLJAK L BATSON S M FICHEUX D | 2003 | JMol Biol2003，329，： | 1 |
| 20 | Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats 显示文摘 | Maric I Poljak L Zoricic S | 2003 | J Cell Physiol2003，196，2： | 1 |
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