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| 1 | Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives显示文摘Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice. | Roberta Gaziano Gabriella Moroni Cristina Buè Martino Tony Miele Paola Sinibaldi-Vallebona Francesca Pica | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 11 |
| 2 | Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients显示文摘AIM:To investigate prevalence,type and time of onset of extraintestinal manifestations(EIMs)in a series of Italian inflammatory bowel disease(IBD)patients.METHODS:Data of 811 IBD consecutive patients,first referred to our Centre from 2000 to 2011,were retrospectively evaluated.RESULTS:Eight hundred and eleven IBD patients(437M,374 F)were studied:595 ulcerative colitis(UC)(73.4%)and 216 Crohn’s disease(CD)(26.6%).Among these,329(40.6%)showed EIMs:210 UC(35.3%)and119 CD(55.1%)(P<0.0001).Considering the time of the diagnosis of IBD,37 EIMs(11.2%)were developed before,229(69.6%)after and 63(19.2%)were simultaneous.The type of EIM were as follows:240 musculoskeletal(29.6%),in 72 CD patients and in 168 UC(P<0.0001);47 mucocutaneous(5.8%),in 26 CD and in21 UC(P=0.0049);26 ocular(3.2%),in 16 CD and in10 UC(CD 7.4%vs UC 1.7%,P=0.0093);6 hepatobiliary(0.8%);10 endocrinological(1.2%).In particular,with regards to the involvement of the musculoskeletal system,arthritis Type 1 was found in 41 CD(19%)and in 61 UC(10.2%)(P=0.0012)and Type 2 in 25 CD(11.6%)and in 100 UC(16.8%)(P=0.0012).CONCLUSION:Mucocutaneous manifestations,arthritis Type 1 and uveitis were significantly more frequent in CD than UC.The complications of the musculoskeletal system were the mostly observed ones,often with symptoms more severe than intestinal ones,confirming the need for close cooperation with rheumatologists. | Maddalena Zippi Claudia Corrado Roberta Pica Eleonora Veronica Avallone Claudio Cassieri Daniela De Nitto Paolo Paoluzi Piero Vernia | 2014 | World Journal of Gastroenterology2014，20，46： | 10 |
| 3 | 莫高窟第85窟现状调查评估显示文摘莫高窟第 85窟的保护是敦煌研究院与美国盖蒂保护所第二期合作项目。洞窟现状调查是该项目的重点内容之一。本文阐述了现状调查的目的及方法 ,并对调查结果进行了讨论 ,为探讨病害机理以及今后的保护规划提供了可靠的基础资料。 | 徐淑青 王旭东 孙洪才 郦伟堂 郑军 Francesca Pica | 2000 | 敦煌研究2000，，1： | 6 |
| 4 | Biological therapy for dermatological manifestations of inflammatory bowel disease显示文摘Ulcerative colitis and Crohn's disease are the two forms of inflammatory bowel disease(IBD). The advent of biological drugs has significantly changed the management of these conditions. Skin manifestations are not uncommon in IBD. Among the reactive lesions(immunemediated extraintestinal manifestations), erythema nodosum(EN) and pyoderma gangrenosum(PG) are the two major cutaneous ills associated with IBD, while psoriasis is the dermatological comorbidity disease observed more often. In particular, in the last few years, anti-tumor necrosis factor(TNF)-α agents have been successfully used to treat psoriasis, especially these kinds of lesions that may occur during the treatment with biological therapies. The entity of the paradoxical manifestations has been relatively under reported as most lesions are limited and a causal relationship with the treatment is often poorly understood. The reason for this apparent side-effect of the therapy still remains unclear. Although side effects may occur, their clinical benefits are undoubted. This article reviews the therapeutic effects of the two most widely used anti-TNF-α molecules, infliximab(a fusion protein dimer of the human TNF-α receptor) and adalimumab(a fully human monoclonal antibody to TNF-α), for the treatment of the major cutaneous manifestations associated with IBD(EN, PG and psoriasis). | Maddalena Zippi Roberta Pica Daniela De Nitto Paolo Paoluzi | 2013 | World Journal of Clinical Cases2013，1，2： | 5 |
| 5 | Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum显示文摘尽管在煽动性的肠疾病和胃肠的感染之间的协会被建议了,涉及 Crohn 的疾病(CD ) 的致病的机制仍然是未经决定的。我们报导以后与 Crohn 的疾病被诊断的一个人,开始由于 Yersinia pseudotubercolosis 感染与 mes 伤寒淋巴腺炎介绍了,的案例。这个案例遵守在建议那 CD 是在遗传上易受影响的个人连接到对伤寒细菌的反常有免疫力的回答的疾病的文学的最近的证据。 | Maddalena Zippi Maria Chiara Colaiacomo Adriana Marcheggiano Roberta Pica Paolo Paoluzi Giancarlo Iaiani Renzo Caprilli Francesca Maccioni | 2006 | World Journal of Gastroenterology2006，12，24： | 5 |
| 6 | 语言学习的研究与课堂教学中所关心的问题显示文摘不论我们是在课堂中进行语言教学,还是进行语言学习的研究,对于我们所从事的工作,我们都有一些共同关心的问题。然而由于语言教师与研究者任务的繁重制约了我们同时去完成这两方面的任务,因而这些共同关心的问题常常被忽略了。当然也有例外的情况。但是即使当我们在语言教学与研究者的不同角色之间有所平衡,我们仍然感到往往较侧重某一种角色而轻视另一种角色。 | Teresa Pica 朱钟毅 | 1995 | 外语教学理论与实践1995，，2： | 4 |
| 7 | Endoscopic papillary balloon dilation for diffi cult common bile duct stones:Our experience显示文摘AIM: To evaluate the eff icacy and safety of endoscopic balloon dilation(EBD) performed for common bile duct(CBD) stones.METHODS: From a computer database, we retrospectively analyzed the data relating to EBD performed in patients at the gastrointestinal unit of the Sandro Pertini Hospital of Rome(small center with low case volume) who underwent endoscopic retrograde cholangiopancreatography(ERCP) for CBD from January 1, 2010 to February 29, 2012. All patients had a proven diagnosis of CBD stones studied with echography, RMN cholangiography and, when necessary, with computed tomography of the abdomen(for example, in cases with pace-makers). Prophylactic therapies, with gabexate mesilate 24 h before the procedure and with an antibiotic(ceftriaxone 2 g) 1 h before, were administered in all patients. The duodenum was intubated with a side-viewing endoscope under deep sedation with intravenous midazolam and propofol. The patients were placed in the supine position in almost all cases. EBDof the ampulla was performed under endoscopic and f luoroscopic guidance with a balloon through the scope(Hercules, wireguided balloon, Cook Ireland Ltd. and CRE, Microvasive, Boston Scientific Co., Natick, MA, United States). RESULTS: A total of 14 patients(9 female, 5 male; mean age of 73 years; range 57-82 years) were enrolled in the study, in whom a total of 15 EBDs were performed. All patients underwent minor endoscopic sphincterotomy(ES) prior to the EBD. The size of balloon insuff lation depended on stone size and CBD dilation and this was performed until it reached 16 mm in diameter. EBD was performed under endoscopic and f luoroscopic guidance. The balloon was gradually f illed with diluted contrast agent and was maintained inf lated in position for 45 to 60 s before def lation and removal. The need for precutting the major papilla was 21.4%. In one patient(an 81-year-old), EBD was performed in a Billroth Ⅱ. Periampullary diverticula were found only in a 74-year-old female. The adverse event related to the procedures(ERCP + ES) was only an intra procedural bleeding(6.6%) that occurred after ES and was treated immediately with adrenaline sclerotherapy. No postoperative complications were reported.CONCLUSION: With the current endoscopic techniques, very few patients with choledocholithiasis require surgery. EBD is an eff icacious and safe procedure. | Maddalena Zippi Isabella De Felici Roberta Pica Giampiero Traversa Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 4 |
| 8 | Schwannoma of the rectum:A case report and literature review显示文摘Schwannoma is a tumor originating from the Schwann cells. Gastrointestinal schwannomas are uncommon stromal tumors of the intestinal tract and, in particular, rectal schwannomas are extremely rare. In fact, it is well established that schwannomas appear more frequently in the stomach and in the small intestine, while location in the colon or in the rectum is uncommon. Reading the literature, only few cases of rectal schwannoma have been reported. Their diagnosis is confirmed by the immunohisto chemical panel(S-100 protein). When these tumors are located in the colon and in the rectum, radical excision with wide margins is mandatory, due to their tendency to recur locally or become malignant, if left untreated. In the present study, we describe a case of a rectal schwannoma occured in a 72-year-old man, presented as a small polypoid lesion, which was successfully removed in toto by hot-biopsy, during the same endoscopy, due to the dimensons. No recurrence of the lesion was observed after 6 mo of follow-up. | Maddalena Zippi Roberta Pica Renzo Scialpi Claudio Cassieri Eleonora Veronica Avallone Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 9 | Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis显示文摘BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the world.Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these patients.These risks also appear to be linked to the duration and the dosage.On the other hand,several studies have emerged with regard to the protective or therapeutic effects of these drugs.More and more evidence underlines the immunomodulatory and anti-fibrotic role of PPIs.In addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host cells.AIM To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and mortality.METHODS A literature review was performed in November 2020.The MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this topic.The search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and keywords.The MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were excluded.We tried to summarize and pool all the data if available.RESULTS A total of 9 studies were found that described the use of PPIs,of which only 5 clearly reported the severity and mortality data in SARS-CoV-2 patients.Our pooled incidence analysis of severe events did not differ between patients with and without PPIs(odds ratio 1.65,95%confidence interval:0.62-4.35)(P=0.314),or for mortality(odds ratio 1.77,95%confidence interval:0.62-5.03)(P=0.286).CONCLUSION Detailed and larger case studies are needed to accurately understand the role of PPIs in this viral infection. | Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong | 2021 | World Journal of Clinical Cases2021，9，12： | 2 |
| 10 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 11 | Adult acquisition of English as a second language under different conditions of exposure显示文摘 | Pica T | 1983 | Language Learning1983，33，4： | 1 |
| 12 | Effect of the addition of palladium on grain growth kinetics of pure titanium显示文摘 | Gil F J Picas J A Manero J M | 1997 | J Alloys Compd1997，260，： | 1 |
| 13 | Thymosin alpha(1) in combination with eytokines and chemtherapy for the treatment of cancer显示文摘 | Garaci E Pica F Sinibaldi-Vallebona P | 2003 | Int Immunopharmacol2003，3，8： | 1 |
| 14 | High doses of thymosin alpha 1 enhance the anti-tumor efficacy of combination chemoimmunotherapy for murine B16 melanoma 显示文摘 | Pica F Fraschetti M Matteucci C | 1998 | Anticancer Res1998，18，5： | 1 |
| 15 | Second-language Acquisition, Social Interaction and the Classroom 显示文摘 | Pica T | 1987 | Applied Linguistics1987，，8： | 1 |
| 16 | Effect of the cutting process on the fatigue behavior of press hardened and high strength dual phase steels 显示文摘 | Lara A Picas I Casellas D | 2013 | Journal of Materials Processing Technology2013，213，11： | 1 |
| 17 | Making Input Comprehensible:Do Interactional Modifications Help? 显示文摘 | Pica T Doughty C & Young R | 1986 | ITL Review of Applied Linguistics1986，，72： | 1 |
| 18 | Methanol permeability and performance of Nafion-zirconium phosphate composite membranes in active and passive direct methanol fuel cells显示文摘 | ARBIZZANI C DONNADIO A PICA M | 2010 | Journal of Power Sources2010，195，： | 1 |
| 19 | Research on Negotiation:What Does It Reveal About Second-language Learning Conditions,Processes,and Outcomes?显示文摘 | T | 1994 | Language Learning1994，44，3： | 1 |
| 20 | 3D surface--relat- ed multiple modeling显示文摘 | Pica A Poulain G David B ect | 2005 | The Leading Edge2005，24，3： | 1 |
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