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您的检索式：作者名="Francesca Pica"
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| 1 | Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives显示文摘Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice. | Roberta Gaziano Gabriella Moroni Cristina Buè Martino Tony Miele Paola Sinibaldi-Vallebona Francesca Pica | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 11 |
| 2 | 莫高窟第85窟现状调查评估显示文摘莫高窟第 85窟的保护是敦煌研究院与美国盖蒂保护所第二期合作项目。洞窟现状调查是该项目的重点内容之一。本文阐述了现状调查的目的及方法 ,并对调查结果进行了讨论 ,为探讨病害机理以及今后的保护规划提供了可靠的基础资料。 | 徐淑青 王旭东 孙洪才 郦伟堂 郑军 Francesca Pica | 2000 | 敦煌研究2000，，1： | 6 |
| 3 | Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum显示文摘尽管在煽动性的肠疾病和胃肠的感染之间的协会被建议了,涉及 Crohn 的疾病(CD ) 的致病的机制仍然是未经决定的。我们报导以后与 Crohn 的疾病被诊断的一个人,开始由于 Yersinia pseudotubercolosis 感染与 mes 伤寒淋巴腺炎介绍了,的案例。这个案例遵守在建议那 CD 是在遗传上易受影响的个人连接到对伤寒细菌的反常有免疫力的回答的疾病的文学的最近的证据。 | Maddalena Zippi Maria Chiara Colaiacomo Adriana Marcheggiano Roberta Pica Paolo Paoluzi Giancarlo Iaiani Renzo Caprilli Francesca Maccioni | 2006 | World Journal of Gastroenterology2006，12，24： | 5 |
| 4 | Thymosin alpha 1 in the treatment of cancer:from basic research to clinical appli- cation显示文摘 | Enrico Garaci Francesca PiCa Guido Rasi | 2000 | International Journal of Immunopharmacology2000，22，： | 1 |
| 5 | Thymosin α1 as a stimulatory agent of innate cell‐mediated immune response显示文摘 | Annalucia Serafino Pasquale Pierimarchi Francesca Pica Federica Andreola Roberta Gaziano Noemi Moroni Manuela Zonfrillo Paola Sinibaldi‐Vallebona Enrico Garaci | 2012 | Annals of the New York Academy of Sciences2012，，1： | 1 |
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