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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | A randomized trial comparing trnsurethral resection of the prostate, laser therapy and conservative largment:the clasp study显示文摘 | Donovan JL Peters TJ Neal DE | 2000 | J Urol2000，164，1： | 1 |
| 3 | Placental lactogen-1 gene activation in diffetentiating trophoblast cells,extrinsic and intrinsic regulation involving mitogen-activated protein kinade singaling pathways显示文摘 | Peters TJ Chapman BM Wolfe MW | 2000 | J Endocrin2000，165，2： | 1 |
| 4 | Transurethral incision compared with transurethral resection of the prostate for bladder outlet obstruction:a systematic review and meta2analysis of randmized controlled trials显示文摘 | Yang Q Peters TJ Donovan JL | | 0，，05： | 1 |
| 5 | A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality: The CopD Study显示文摘 | Darshana Durup Henrik L?vendahl J?rgensen Jane Christensen Anne Tj?nneland Anja Olsen Jytte Halkj?r Bent Lind Anne-Marie Heegaard Peter Schwarz | 2015 | The Journal of Clinical Endocrinology & Metabolism2015，，6： | 1 |
| 6 | Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum 显示文摘 | Cashmore TJ Peter JG van Zyl-Smit RN | 2010 | PLoS One2010，5，10： | 1 |
| 7 | A randomized trial compating transurethral resection of the prostate,laser therapy and conservative treatment of men with symptoms associated with benign prostatic enlargement:the Clas P study显示文摘 | Donovan JL Peters TJ Neal DE | 2000 | J Urol2000，164，： | 1 |
| 8 | A randomized trial comparing transurethral resection of the prostate, laser therapy and conservative largment : the clasp study 显示文摘 | Donovan JL Peters TJ Neal DE | 2000 | J Uroh2000，164，1： | 1 |
| 9 | The international continence society' benign prostatic hyperplasia' study: the bothersomeness of urinary symptoms显示文摘 | Peters TJ Donovan JL Kay HE | 1997 | J Urol1997，157，2： | 1 |
| 10 | Severity of depr- ession and response to antidepressants: GENPOD ran- domised controlled trial 显示文摘 | Wiles NJ Mulligan J Peters TJ | 2012 | Br J Psychia2012，200，2： | 1 |
| 11 | Common carotid inti- ma- media thickness measurements in cardiovascular risk predic- tion :a meta -analysis显示文摘 | Den Ruijter HM Peters SA Anderson TJ | 2012 | JAMA2012，30，8： | 1 |
| 12 | Does smoking influence acne? 显示文摘 | Mills CM Peters TJ Finlay AY | 1993 | Clin Exp Dermatol1993，18，2： | 1 |
| 13 | Identification of acute porphyria:evaluation of a commercial screening test for urinary porphobilinogen显示文摘 | Deacon AC Peters Tj | 1998 | Ann Clin Biochem1998，35，： | 1 |
| 14 | Common carotid intima-media thickness measurements in cardio- vascular risk prediction: a meta-analysis显示文摘 | Den Ruijter HM Peters SA Anderson TJ | 2012 | JAMA2012，308，8： | 1 |
| 15 | Enhanced p73 expressioon during differentiation and complex p173 isoforms in myeloid leukemia显示文摘 | Grob TJ Peters UR | 2000 | Biochem Biophys Res Commun2000，277，1： | 1 |
| 16 | A randomized trial comparing transurethral resection of the prostate,laser therapy and conservative treatment of men with symptoms associated with benign prostatic enlargement : The CLasP study显示文摘 | Donovan JL Peters TJ Neal DE | 2000 | J Urol2000，164，1： | 1 |
| 17 | Transurethral incision compared with transurethral resection of the prostate for bladder outer obstruction:a systematic review and meta-analysis of randomized controlled trials显示文摘 | Yang Q Peters TJ Donovan JL | 2001 | J Urol2001，165，5： | 1 |
| 18 | Transurethral incision compared with transurethral resection of the prostate for bladder outlet obstruction显示文摘 | Yang Q Peters TJ Donovan JL | | 0，，05： | 1 |
| 19 | Peripheral and Gasserian ganglion-level procedures for the treatment of trigeminal neuralgia显示文摘 | Peters G Nurmikko TJ | 2002 | Clin J Pain2002，18，： | 1 |
| 20 | Transurethral incision com- pared with transurethral resection of the prostate for bladder outer obstruction: a systematic review and meta-analysis of randomized controlled trials显示文摘 | Yang Q Peters TJ Donovan JL | 2001 | J Urol2001，165，5： | 1 |
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